Abstract
Objectives:
Abdominal Aortic Aneurysm (AAA) is a complex disease with both genetic and environmental risk factors. This study aimed to examine the potential association of the +276G/T and −420C>G polymorphisms in the resistin gene with AAA susceptibility and progression.
Method:
We performed a retrospective study involving AAA patients and healthy controls, assessing the distribution of the +276G/T and −420C>G genotypes in both groups. Hardy-Weinberg equilibrium was assessed for both polymorphisms. Logistic regression was used to explore the influence of these genotypes on AAA occurrence and progression, adjusting for relevant confounders.
Results:
The distribution of +276G/T polymorphism did not significantly differ between AAA patients and controls. Conversely, a significant difference was observed in the genotype distribution of −420C>G polymorphism between the two groups. The CC genotype and CC/CG genotypes of −420C>G polymorphism were found to be associated with an increased risk and progression of AAA.
Conclusions:
The −420C>G polymorphism, particularly the CC genotype and CC/CG genotypes, might play a substantial role in AAA susceptibility and progression. The present findings underscore the need for further investigations to confirm these associations and fully elucidate the role of the resistin gene in AAA.
Keywords:
Gene polymorphisms; Adiponectin; Resistin; Abdominal aortic aneurysm; Genetic susceptibility
Highlights
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Examined resistin gene polymorphisms' link with AAA.
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−420C>G (especially CC/CG) tied to AAA risk & progression.
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+276G/T polymorphism showed no AAA association.
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Resistin gene’s potential role in AAA highlighted.