Cho (2017)99 Cho PG, Ji GY, Shin DA, Ha Y, Yoon DH, Kim KN. An effect comparison of teriparatide and bisphosphonate on posterior lumbar interbody fusion in patients with osteoporosis: a prospective cohort study and preliminary data. Eur Spine J. 2017;26(3):691-7. doi:10.1007/s00586-015-4342-y. https://doi.org/10.1007/s00586-015-4342-...
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47 |
Evaluation and comparison of teriparatide vs. PLIF bisphosphonate efficacy |
Teriparatide increases the rate of early fusion (6m) and bone formation concerning alendronate. Teriparatide 20 micrograms daily for one-year pop fusion 89%. |
Cohort R |
Tsai (2016)1111 Tsai JN, Uihlein AV, Burnett-Bowie SM, Neer RM, Derrico NP, Lee H, et al. Effects of two years of teriparatide, denosumab, or both on bone microarchitecture and strength (DATA-HRpQCT study). J Clin Endocrinol Metab. 2016;101(5):2023-30. doi:10.1210/jc.2016-1160. https://doi.org/10.1210/jc.2016-1160...
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94 |
Bone formation efficacy of teriparatide, denosumab, and their combination in osteoporosis. |
Combining teriparatide and denosumab improves bone architecture in osteoporotic patients concerning individual pharmacological management. Teriparatide 20 mcg/day |
Randomized controlled clinical trial. R |
Inoue (2014)1313 Inoue G, Ueno M, Nakazawa T, Imura T, Saito W, Uchida K, et al. Teriparatide increases the insertional torque of pedicle screws during fusion surgery in patients with postmenopausal osteoporosis. J Neurosurg Spine. 2014;21(3):425-31. doi:10.3171/2014.5.SPINE13656. https://doi.org/10.3171/2014.5.SPINE1365...
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29 |
To evaluate the effect of teriparatide on screw torque in fusion surgery patients with osteoporosis. |
Administration of teriparatide one month before surgery improves screw torque at fusion. |
Cohort . R |
Kim (2018)1414 Kim JW, Park SW, Kim YB, Ko MJ. The effect of postoperative use of teriparatide reducing screw loosening in osteoporotic patients. J Korean Neurosurg Soc. 2018;61(4):494-502. doi:10.3340/jkns.2017.0216. https://doi.org/10.3340/jkns.2017.0216...
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84 |
To determine the effect of teriparatide vs. bisphosphonates on screw loosening in spinal surgery in the osteoporotic patient. |
Teriparatide significantly decreases screw loosening by 2.3% vs. bisphosphonates 9.2% p<0.05. Dose 20 mcg/day for six months pop. |
Case study. R |
Oba (2020)1515 Oba H, Takahashi J, Yokomichi H, Hasegawa T, Ebata S, Mukaiyama K, et al. Weekly teriparatide versus bisphosphonate for bone union during 6 months after multi-level lumbar interbody fusion for osteoporotic patients: A multicenter, prospective, randomized study. Spine 2020;45(13):863-71. doi:10.1097/BRS.0000000000003426. https://doi.org/10.1097/BRS.000000000000...
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104 |
To compare multilevel fusion in osteoporosis > 50 years teriparatide vs bisphosphonates. Determine the efficacy of teriparatide in posterolateral fusion in osteoporosis. |
There is an increasing trend in fusion with teriparatide 46% in the first six months concerning bisphosphonates 32%. No significant differences in multilevel lumbar fusion. |
Prospective randomized multicenter clinical trial. |
Ohtori (2012)1616 Ohtori S, Inoue G, Orita S, Yamauchi K, Eguchi Y, Ochiai N, et al. Teriparatide accelerates lumbar posterolateral fusion in women with postmenopausal osteoporosis: Prospective study. Spine. 2012;37(23):E1464-8. doi:10.1097/BRS.0b013e31826ca2a8. https://doi.org/10.1097/BRS.0b013e31826c...
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57 |
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The fusion rate with teriparatide was 82% at eight months vs. 68% at ten months with bisphosphonates in posterolateral fusion. |
Prospective R |
Ohtori (2013)1717 Ohtori S, Inoue G, Orita S, Yamauchi K, Eguchi Y, Ochiai N, et al. Comparison of teriparatide and bisphosphonate treatment to reduce pedicle screw loosening after lumbar spinal fusion surgery in postmenopausal women with osteoporosis from a bone quality perspective. Spine. 2013;38(8):E487-92. doi:10.1097/BRS.0b013e31828826dd. https://doi.org/10.1097/BRS.0b013e318288...
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62 |
To evaluate teriparatide efficacy of pedicle screw loosening rate. |
Pedicle screw loosening rate 7 to 13% teriparatide vs. 15 to 25% control, one-year p<0.05. |
Prospective R |
Ebata (2017)1818 Ebata S, Takahashi J, Hasegawa T, Mukaiyama K, Isogai Y, Ohba T, et al. Role of weekly teriparatide administration in osseous union enhancement within six months after posterior or transforaminal lumbar interbody fusion for osteoporosis-associated lumbar degenerative disorders: A multicenter, prospective randomized study. J Bone Joint Surg Am. 2017;99(5):365-72. doi:10.2106/JBJS.16.00230. https://doi.org/10.2106/JBJS.16.00230...
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66 |
To evaluate bone fusion and bone formation in PLIF or TLIF with teriparatide in patients with osteoporosis by tomography. |
Weekly teriparatide 20 mcg increases bone formation and fusion. Indicated for osteoporosis in patients with degenerative spinal pathology. |
Prospective randomized multicenter R |
Seki (2017)1919 Seki S, Hirano N, Kawaguchi Y, Nakano M, Yasuda T, Suzuki K, et al. Teriparatide versus low-dose bisphosphonates before and after surgery for adult spinal deformity in female Japanese patients with osteoporosis. Eur Spine J. 2017;26(8):2121-7. doi:10.1007/s00586-017-4959-0. https://doi.org/10.1007/s00586-017-4959-...
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58 |
To evaluate complications in spinal surgery by administering teriparatide and low doses of bisphosphonates. |
Perioperative teriparatide decreases complications and maintains the fusion rate more effectively than bisphosphonates in osteoporotic patients with spinal deformity. Screw loosening 0.009, adjacent vertebral fracture 0.00007. |
Prospective R |
Ide (2018)1010 Ide M, Yamada K, Kaneko K, Sekiya T, Kanai K, Higashi T, et al. Combined teriparatide and denosumab therapy accelerates spinal fusion following posterior lumbar interbody fusion. Orthop Traumatol Surg Res. 2018;104(7):1043-8. doi:10.1016/j.otsr.2018.07.015. https://doi.org/10.1016/j.otsr.2018.07.0...
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16 |
Evaluating lumbar spinal fusion in osteoporosis with the addition of denosumab to teriparatide. |
There is an increase in the rate of spinal fusion and bone formation with the combination of teriparatide and denosumab six months after surgery, p < 0.05. |
Prospective randomized clinical trial R |
Ebina (2017)2020 Ebina K, Hashimoto J, Kashii M, Hirao M, Kaneshiro S, Noguchi T, et al. The effects of switching daily teriparatide to oral bisphosphonates or denosumab in patients with primary osteoporosis. J Bone Miner Metab. 2017;35(1):91-98.
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78 |
To evaluate the fusion and increase in bone mineral density of teriparatide associated with denosumab and bisphosphonates. |
Denosumab associated with teriparatide increases bone mineral density by 6.2 vs. 2.6% concerning bisphosphonates and teriparatide and decreases the rate of bone resorption. |
Observational R |
Tseng (2012)2121 Tseng YY, Su CH, Lui TN, Yeh YS, Yeh SH. Prospective comparison of the therapeutic effect of teriparatide with that of combined vertebroplasty with antiresorptive agents for the treatment of new-onset adjacent vertebral compression fracture after percutaneous vertebroplasty. Osteoporos Int. 2012;23(5):1613-22. doi:10.1007/s00198-011-1730-y. https://doi.org/10.1007/s00198-011-1730-...
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50 |
To evaluate the use of teriparatide alone vs. vertebroplasty plus bisphosphonates in managing vertebral fractures adjacent to previous vertebroplasty for osteoporosis. |
Patients treated with teriparatide had a 78.5% decrease in vertebral fractures (post vertebroplasty) odds ratio=0.21; 95% CI l, 0.02-2.10) with VAS (visual analog scale) decrease at six months P < 0.05, concerning the combination of new vertebroplasty and bisphosphonates. |
Prospective randomized comparative R |
Kaliya-Perumal (2016)2222 Kaliya-Perumal AK, Lu ML, Luo CA, Tsai TT, Lai PL, Chen LH, et al. Retrospective radiological outcome analysis following teriparatide use in elderly patients undergoing multilevel instrumented lumbar fusion surgery. Medicine. 2017;96(5):e5996. doi:10.1097/MD.0000000000005996. https://doi.org/10.1097/MD.0000000000005...
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62 |
To evaluate the effectiveness of teriparatide in multilevel lumbar fusion in patients with osteoporosis concerning placebo. |
Teriparatide in posterolateral multilevel fusion increased the fusion rate by 16.7% and decreased loosening by 11% concerning the control group. |
Observational, controlled, retrospective R |
Ushirozako (2018)2323 Ushirozako H, Hasegawa T, Ebata S, Oba H, Ohba T, Mukaiyama K, et al. Weekly Teriparatide Administration and Preoperative Anterior Slippage of the Cranial Vertebra next to Fusion Segment < 2mm Promote Osseous Union after Posterior Lumbar Interbody Fusion. Spine. 2019;44(5):E288-97. doi:10.1097/BRS.0000000000002833. https://doi.org/10.1097/BRS.000000000000...
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60 |
To determine the predictors of lumbar fusion after PLIF. |
The administration of teriparatide weekly and for six months postoperatively allows a union rate of 61% vs. 27% and bone bridging of 49% vs. 12% concerning those who did not receive it. p < 0.01. |
Multi-center case-control R |