| Hasan et al. (2021)1212 Hasan MS, Yunus SN, Ng CC, Chan CYW, Chiu CK, Kwan MK. Tranexamic acid in pediatric scoliosis surgery: a prospective randomized trial comparing high-dose and low-dose tranexamic acid in adolescent idiopathic scoliosis undergoing posterior spinal fusion surgery. Spine. 2021;46(22):E1170-7.
|
Low dose:10mg/kg-
1mg/kg/h
High dose: 30mg/kg-10mg/kg/h |
no difference between high and low dose |
| Hideshima et al. (2021)1414 Hideshima T, Akazawa T, Iinuma M, Torii Y, Ueno J, Yoshida A, et al. Tranexamic Acid Reduces Total Blood Loss and the Amount of Stored Preoperative Autologous Blood Donation Needed for Adolescent Idiopathic Scoliosis Patients Undergoing Posterior Spinal Fusion. Cureus. 2021;13(6):e15488.
|
1000mg, 1000mg every 5h surgery |
73% |
| Halpern et al. (2021)1515 Halpern LM, Bronson WE, Kogan CJ. A new low dose of tranexamic acid for decreasing the rate of blood loss in posterior spinal fusion for adolescent idiopathic scoliosis. J Pediatr Orthop. 2021;41(6):333-7.
|
10mg/kg-5mg/kg/h |
18% |
| Tumber et al. (2021)1616 Tumber S, Bacon A, Stondell C, Tafoya S, Taylor SL, Javidan Y, et al. High-versus low-dose tranexamic acid as part of a Patient Blood Management strategy for reducing blood loss in patients undergoing surgery for adolescent idiopathic scoliosis. Spine Deform. 2022;10(1):107-13.
|
Low dose: 20mg/kg-10mg/kg/h
High dose: 50mg/kg-10mg/kg/h |
37.5% HIGH DOSE GROUP |
| Bosch et al. (2019)1717 Bosch P, Kenkre TS, Soliman D, Londino JA, Novak NE. Comparison of the coagulation profile of adolescent idiopathic scoliosis patients undergoing posterior spinal fusion with and without tranexamic acid. Spine Deform. 2019;7(6):910-6.
|
30mg/kg-10mg/kg/h |
No reduction identified |
| Goobie et al. (2018)77 Goobie SM, Zurakowski D, Glotzbecker MP, McCann ME, Hedequist D, Brustowicz RM, et al. Tranexamic acid is efficacious at decreasing the rate of blood loss in adolescent scoliosis surgery: a randomized placebo-controlled trial. JBJS. 2018;100(23):2024-32.
|
50mg/kg-10mg/kg/h |
27% |
| Jones et al. (2017)1818 Jones KE, Butler EK, Barrack T, Ledonio CT, Forte ML, Cohn CS, et al. Tranexamic acid reduced the percent of total blood volume lost during adolescent idiopathic scoliosis surgery. Int J Spine Surg. 2017;11(4):27.
|
10mg/kg-1mg/kg/h |
57% |
| Johnson et al. (2017)44 Johnson DJ, Johnson CC, Goobie SM, Nami N, Wetzler JA, Sponseller PD, et al. High-dose versus low-dose tranexamic acid to reduce transfusion requirements in pediatric scoliosis surgery. J Pediatr Orthop. 2017;37(8):e552-7.
|
50mg/kg-5mg/kg/h |
28% |
| Sui et al. (2016)1919 Sui WY, Ye F, Yang JL. Efficacy of tranexamic acid reduces allogeneic blood products in adolescent idiopathic scoliosis surgery. BMC Musculoskelet Disord. 2016;17:187.
|
100mg/kg-10mg/kg/h |
57% |
| Ng et al. (2015)2020 Ng BK, Chau WW, Hung AL, Hui AC, Lam TP, Cheng JC. Use of Tranexamic Acid (TXA) on reducing blood loss during scoliosis surgery in Chinese adolescents. Scoliosis. 2015;10:28.
|
100mg/kg-10mg/kg/h |
53% |
| Berney et al. (2015)2121 Berney MJ, Dawson PH, Phillips M, Lui DF, Connolly P. Eliminating the use of allogeneic blood products in adolescent idiopathic scoliosis surgery. Eur J Orthop Surg Traumatol. 2015;25(Suppl 1):219-23.
|
15mg/kg-10mg/kg/h |
45% |
| Rocha et al. (2015)2222 Rocha VM da, Barros AGC de, Naves CD, Gomes NL, Lobo JC, Schettino LCV, et al. Use of tranexamic acid for controlling bleeding in thoracolumbar scoliosis surgery with posterior instrumentation. Rev Bras Ortop. 2015;50(2):226-31.
|
100mg/kg-30mg/kg/h |
29.7% |
| Ngo et al. (2013)2323 Ngo KT, Khemani RG, Choi PD, Ross PA. Tranexamic acid reduces PRBC transfusion after posterior spine surgery for idiopathic scoliosis from the operating room to post-operative day four. J Anesthe Clin Res. 2013;4(7):1000338.
|
50mg/kg-5 to 10mg/kg/h |
20.54% |
| Lykissas et al. (2013)2424 Lykissas MG, Crawford AH, Chan G, Aronson LA, Al-Sayyad MJ. The effect of tranexamic acid in blood loss and transfusion volume in adolescent idiopathic scoliosis surgery: a single-surgeon experience. J Child Orthop. 2013;7(3):245-9.
|
100mg/kg-10mg/kg/h |
57% |
| Verma et al. (2014)2525 Verma K, Errico T, Diefenbach C, Hoelscher C, Peters A, Dryer J, et al. The relative efficacy of antifibrinolytics in adolescent idiopathic scoliosis: a prospective randomized trial. JBJS. 2014;96(10):e80.
|
10mg/kg-1mg/kg/h |
14% |
| Yagi et al. (2012)2626 Yagi M, Machida M, Nagoshi N, Iizuka S, Kaneko S, Kaneko S, et al. Does the intraoperative tranexamic acid decrease operative blood loss during posterior spinal fusion for treatment of adolescent idiopathic scoliosis?. Spine (Phila Pa 1976). 2012;37(21):E1336-42.
|
1000mg-100mg/kg/h |
43% |
| Grant et al. (2009)2727 Grant JA, Howard J, Luntley J, Harder J, Aleissa S, Parsons D. Perioperative blood transfusion requirements in pediatric scoliosis surgery: the efficacy of tranexamic acid. J Pediatr Orthop. 2009;29(3):300-4.
|
20mg/kg-10mg/kg/h |
50% |
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