Summarized Methodology |
Biological Potential |
Reference |
Dissolution in PCL-PEG-PCL in DCM + dH2O + Sonication + Solvent evaporation |
Anticancer in breast cancer cell line |
EATEMADI et al. (2016EATEMADI, A. et al. Synthesis and Characterization of chrysin-loaded PCL-PEG-PCL nanoparticle and its effect on breast cancer cell line. Biomedicine & Pharmacotherapy, v.84, p.1915-1922, 2016. Available from: <Available from: https://doi.org/10.1016/j.biopha.2016.10.095 >. Accessed: Dec. 08, 2022. doi: 10.1016/j.biopha.2016.10.095. https://doi.org/10.1016/j.biopha.2016.10...
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Mix of water-surfactant solution containing chrysin and stearic acid completely melted + Equilibrate at ~75 °C + Homogenization + Agitation near ice cold water + Centrifugation + Resuspension of pellet in distilled water |
Ameliorates neurobehavioral alterations of Alzheimer’s |
VEDAGIRI &THANGARAHAN (2016VEDAGIRI, A.; THANGARAHAN, S. Mitigating effect of chrysin loaded solid lipid nanoparticles against Amyloid β25-35 induced oxidative stress in rat hippocampal region: An efficient formulation approach for Alzheimer’s disease. Neuropeptides, v.58, p.111-125, 2016. Available from: <Available from: https://doi.org/10.1016/j.npep.2016.03.002 >. Accessed: Dec. 12, 2022. doi: 10.1016/j.npep.2016.03.002. https://doi.org/10.1016/j.npep.2016.03.0...
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Dissolution of chrysin in ethanol + Recrystallizatedβ-cyclodextrin dissolved in H2O with continuous stirring + Crystallization in refrigerator + Vacuum filtration + Drying |
Antioxidant, antimicrobial and anti-tumor activity |
ZHU et al. (2016ZHU, Z. et al. Inclusion of chrysin in β-cyclodextrin and its biological activities. Journal of Drug Delivery Science and Technology, v.31, p.176-186, 2016. Available from: <Available from: https://doi.org/10.1016/j.jddst.2016.01.002 >. Accessed: Dec. 09, 2022. doi: 10.1016/j.jddst.2016.01.002. https://doi.org/10.1016/j.jddst.2016.01....
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Dissolution with PLGA-PEG tri-block copolymer in DCM-methanol + Agitation + PVA + sonication + Vacuum vaporization of the solvent + Centrifugation + Washing with dH2O + Lyophilization |
Possible aplicattion in tissue regeneration |
FIROUZI-AMANDI et al. (2018FIROUZI-AMANDI, A. et al. Chrysin-nanoencapsulated PLGA-PEG for macrophage repolarization: Possible application in tissue regeneration. Biomedicine & Pharmacotherapy, v.105, p.773-780, 2018. Available from: <Available from: https://doi.org/10.1016/j.biopha.2018.06.037 >. Accessed: Dec. 08, 2022. doi: 10.1016/j.biopha.2018.06.037. https://doi.org/10.1016/j.biopha.2018.06...
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Addition in dozorubicin/(PLGA-co-PMAA) copolymer + Sonication + PVA and agitation + Centrifugation + Washing with dH2O and centrifugation |
Anticancer effect in lung epithelial cancer cell lines |
JABBARI et al. (2018JABBARI, S. et al. Doxorubicin and chrysin combination chemotherapy with novel pH-responsive poly [(lactide-co-glycolic acid)-block-methacrylic acid] nanoparticle. Journal of Drug Delivery Science and Technology, v.46, p.129-137, 2018. Available from: <Available from: https://doi.org/10.1016/j.jddst.2018.05.006 >. Accessed: Dec. 08, 2022. doi: 10.1016/j.jddst.2018.05.006. https://doi.org/10.1016/j.jddst.2018.05....
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Dissolution of carboxymethyl cellulose in dH2O + Addition of chrysin dissolved in DMSO + Addition of Chitosan + Agitation + Addition of nano-hydroxyapatite + Agitation + Addition of acetic acid + Solution cast into plate + Lyophilization |
Mesenchymal stem cell proliferation and osteoblast differentiation |
MENON et al. (2018MENON, A. H. et al. Sustained release of chrysin from chitosan-based scaffolds promotes mesenchymal stem cell proliferation and osteoblast differentiation. Carbohydrate Polymers, v.195, p.356-367, 2018. Available from: <Available from: https://pubmed.ncbi.nlm.nih.gov/29804987/ >. Accessed: Dec. 12, 2022. doi: 10.1016/j.carbpol.2018.04.115. https://pubmed.ncbi.nlm.nih.gov/29804987...
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Dissolution of chrysin in DMSO + Addition of chrysin solution to BSAnp in PBS + Agitation |
Antitumor therapies |
FERRADO et al. (2019FERRADO, J. B. et al. Formation and characterization of self-assembled bovine serum albumin nanoparticles as chrysin delivery systems. Colloids and Surfaces B: Biointerfaces, v.173, p.43-51, 2019. Available from: <Available from: https://doi.org/10.1016/j.colsurfb.2018.09.046 >. Accessed: Dec. 08, 2022. doi: 10.1016/j.colsurfb.2018.09.046. https://doi.org/10.1016/j.colsurfb.2018....
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Dissolution with poly(ε-caprolactone), pomegranate oil, and sorbitanmonostearate in acetone + Addition to the aqueous phase (polysorbate H2O) with magnetic stirring + Acetone evaporation by rotary evaporator + Concentration of suspensions under reduced pressure |
Ameliorates neurobehavioral alterations of Alzheimer’s disease in mice |
GIACOMELI et al. (2020GIACOMELI, R. et al. Chrysin loaded lipid-core nanocapsules ameliorates neurobehavioral alterations induced by β-amyloid1-42 in aged female mice. Behavioural Brain Research, v.390, 2020. Available from: <Available from: https://doi.org/10.1016/j.bbr.2020.112696 >. Accessed: Dec. 09, 2022. doi: 10.1016/j.bbr.2020.112696. https://doi.org/10.1016/j.bbr.2020.11269...
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Dissolution of chrysin and curcumine in PLGA/PEG + Magnetic stirring + Electrospinning + Nfs drying in a vacuum oven |
Effect on T47D breast cancer cells |
RASOULI et al. (2020RASOULI, S. et al. Synergistic anticancer effects of electrospun nanofiber-mediated codelivery of curcumin and chrysin: Possible application in prevention of breast cancer local recurrence. Journal of Drug Delivery Science and Technology, v.55, 2020. Available from: <Available from: https://doi.org/10.1016/j.jddst.2019.101402 >. Accessed: Dec. 12, 2022. doi: 10.1016/j.jddst.2019.101402. https://doi.org/10.1016/j.jddst.2019.101...
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Dissolution of chrysin and PLGA in acetone + Mix with PVA + Centrifugation + Lyophilization |
Attenuation of allergic asthma |
ROY et al. (2020ROY, S. et al. Chrysin-loaded PLGA attenuates OVA-induced allergic asthma by modulating TLR/NF-κB/NLRP3 axis. Nanomedicine: Nanotechnology, Biology, and Medicine, v.30, 2020. Available from: <Available from: https://pubmed.ncbi.nlm.nih.gov/32853785/ >. Accessed: Dec. 12, 2022. doi: 10.1016/j.nano.2020.102292. https://pubmed.ncbi.nlm.nih.gov/32853785...
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Dissolution with PLGA, Labrafac PG and phosphatidylcholine in acetone + Addition dropwise to an aqueous solution of tween 80 placed on a magnetic stirrer + Evaporation of the organic solvent |
Anti-glycemic and anti-hyperlipidemic |
EL-HUSSIEN et al. (2021EL-HUSSIEN, D. et al. Chrysinnanocapsules with dual anti-glycemic and anti-hyperlipidemic effects: Chemometric optimization, physicochemical characterization and pharmacodynamic assessment. International Journal of Pharmaceutics, v.592, 2021. Available from: <Available from: https://doi.org/10.1016/j.ijpharm.2020.120044 >. Accessed: Dec. 09, 2022. doi: 10.1016/j.ijpharm.2020.120044. https://doi.org/10.1016/j.ijpharm.2020.1...
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Dissolution of chrysin in DMSO + Agitation + Addition to Au nanocapsules solution + Agitation + Centrifugation |
Antioxidant, anti-microbial and cytotoxic |
JASIM et al. (2022)JASIM, A. J. et al. Preliminary trials of the gold nanoparticles conjugated chrysin: An assessment of anti-oxidant, anti-microbial, and in vitro cytotoxic activities of a nanoformulated flavonoid. Nanotechnology Reviews, v.11, p.2726-2741, 2022. Available from: <Available from: https://www.degruyter.com/document/doi/10.1515/ntrev-2022-0153/html >. Accessed: Dec. 12, 2022. doi: 10.1515/ntrev-2022-0153 https://www.degruyter.com/document/doi/1...
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Dissolution in DCM and acetone + Emulsification with PVA + Centrifugation + Supernadant discard + Drying and pelletizing |
Antioxidant, antidiabetic and antiglycating |
KHALID &NASEEM (2022KHALID, A.; NASEEM, I. Antidiabetic and antiglycating potential of chrysin is enhanced after nano formulation: An in vitro approac. Journal of Molecular Structure, v.1261, n.5, 2022. Available from: <Available from: https://ui.adsabs.harvard.edu/abs/2022JMoSt126132906K/abstract >. Accessed: Dec. 08, 2022. doi: 10.1016/j.molstruc.2022.132906. https://ui.adsabs.harvard.edu/abs/2022JM...
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Chrysin and metformin mixed with polymer + Placed in rotary flask + Addition of DCM + Sonication + Solvent evaporation + Hydration + Filtration |
Effect in breast cancer in mice |
LUO et al. (2022LUO, D. et al. MPEG-PCL nanomicelles platform for synergistic metformin and chrysin delivery to breast cancer in mice. Anti-Cancer Agents in Medicinal Chemistry, v.2, p.280-293, 2022. Available from: <Available from: https://pubmed.ncbi.nlm.nih.gov/34165412/ >. Accessed: Dec. 12, 2022. doi: 10.2174/1871520621666210623092725. https://pubmed.ncbi.nlm.nih.gov/34165412...
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