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MICROBIOLOGY • Cienc. Rural 51 (3) • 2021 • https://doi.org/10.1590/0103-8478cr20200783 linkcopy

Open-access Fecal microbiota transplantation via colonoscopy in a dog with Clostridioides (Clostridium) difficile infection

Transplante de microbiota fecal via colonoscopia em um cão com infecção por Clostridioides (Clostridium) difficile

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    ABSTRACT:

    In dogs, antimicrobial therapy for Clostridioides (Clostridium) difficile infection (CDI) is based solely on metronidazole, leaving limited treatment options in case of recurrent disease. Fecal microbiota transplantation (FMT) has been successfully used in humans with recurrent CDI, whereas the usefulness of this approach is largely unknown in dogs. In the present study, a dog with a chronic-recurring diarrhea was treated with FMT via colonoscopy. CDI was confirmed by A/B toxin detection and isolation of toxigenic C. difficile from ribotype 106, a strain also commonly associated with nosocomial infection in humans. The dog recovered well after the procedure and C. difficile was no longer isolated from its stool sample. The present research suggested that FMT could be a useful tool to treat recurrent CDI in dogs, corroborating the actual protocol in humans.

    Key words:
    canine diarrhea; FMT; colitis

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    Universidade Federal de Santa Maria Universidade Federal de Santa Maria, Centro de Ciências Rurais , 97105-900 Santa Maria RS Brazil , Tel.: +55 55 3220-8698 , Fax: +55 55 3220-8695 - Santa Maria - RS - Brazil
    E-mail: cienciarural@mail.ufsm.br
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