Aortic thrombosis in a dog with chronic lymphocytic leukemia

Ripplinger, Angel; Silva, Ana Paula da; Wrzesinski, Mathias Reginatto; Ferrarin, Dênis Antonio; Schwab, Marcelo Luís; Pozzobon, Ricardo; Flores, Mariana Martins; Thompson, Ruth Pamela; Mario, Fabiana; Mazzanti, Alexandre

doi:10.1590/0103-8478cr20190719

Acessibilidade / Reportar erro

Brasil
SciELO.org - Rede SciELO
Blog SciELO em Perspectiva

Abrir menu

Brasil

Español English

Ciência Rural

Submissão de manuscritos
Sobre o periódico
Corpo Editorial
Instruções aos autores
Contato

sumário « anterior atual seguinte »

Resumo (Inglês)
Resumo (Português)

Texto (Inglês)

Download PDF (Inglês)

Compartilhe

Compartilhe
E-mail
Facebook
Twitter
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley

Sumário

Compartilhe
E-mail
Facebook
Twitter
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley

Resumo (Inglês)
Resumo (Português)

Texto (Inglês)

Download PDF (Inglês)

CLINIC AND SURGERY • Cienc. Rural 50 (4) • 2020 • https://doi.org/10.1590/0103-8478cr20190719 copy

Aortic thrombosis in a dog with chronic lymphocytic leukemia

Trombose aórtica em cão com leucemia linfocítica crônica

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT:

The aim of this report was to describe a case of aortic thrombosis (AT) secondary to chronic lymphocytic leukemia (CLL). Although, different types of neoplasms are described as possible causes of aortic thrombosis, CLL was not yet considered. The dog showed signs of lameness that worsened with exercise. The diagnosis of AT was made by ultrasound examination. The diagnosis of CLL was made by necropsy, which showed the presence of small lymphocytes with the appearance of mature lymphocytes in the bone marrow, spleen, liver and kidneys. The importance of including CLL in the possible causes of AT in dogs, in addition to the suspicion of AT in cases of neuromuscular disease, was highlighted.

Key words:
canine; lymphoid leukemia; ischemic neuromyopathy; thrombus

Authorship

Angel Ripplinger

Programa de Pós-Graduação em Medicina Veterinária, Universidade Federal de Santa Maria (UFSM), Centro de Ciências Rurais (CCR), Santa Maria, RS, Brasil.Universidade Federal de Santa Maria (UFSM)BrazilSanta Maria, RS, BrazilPrograma de Pós-Graduação em Medicina Veterinária, Universidade Federal de Santa Maria (UFSM), Centro de Ciências Rurais (CCR), Santa Maria, RS, Brasil.

http://orcid.org/0000-0003-1982-8855

Ana Paula da Silva

Clínica Médica de Pequenos Animais, Hospital Veterinário Universitário (HVU), Centro de Ciências Rurais (CCR) , Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brasil.Universidade Federal de Santa Maria (UFSM)BrazilSanta Maria, RS, BrazilClínica Médica de Pequenos Animais, Hospital Veterinário Universitário (HVU), Centro de Ciências Rurais (CCR) , Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brasil.

http://orcid.org/0000-0001-7388-8475

Mathias Reginatto Wrzesinski

http://orcid.org/0000-0002-1691-4451

Dênis Antonio Ferrarin

http://orcid.org/0000-0002-6534-5398

Marcelo Luís Schwab

http://orcid.org/0000-0001-8203-1764

Ricardo Pozzobon

Departamento de Clínica de Grandes Animais, Centro de Ciências Rurais (CCR), Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brasil.Universidade Federal de Santa Maria (UFSM),BrazilSanta Maria, RS, BrazilDepartamento de Clínica de Grandes Animais, Centro de Ciências Rurais (CCR), Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brasil.

Mariana Martins Flores

Departamento de Patologia, Centro de Ciências da Saúde (CCS), Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brasil.Universidade Federal de Santa Maria (UFSM)BrazilSanta Maria, RS, BrazilDepartamento de Patologia, Centro de Ciências da Saúde (CCS), Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brasil.

Ruth Pamela Thompson

Fabiana Mario

Residência Multiprofissional em Medicina Veterinária, Área de Diagnóstico por Imagem, Hospital Veterinário Universitário (HVU), Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brasil.Universidade Federal de Santa Maria (UFSM)BrazilSanta Maria, RS, BrazilResidência Multiprofissional em Medicina Veterinária, Área de Diagnóstico por Imagem, Hospital Veterinário Universitário (HVU), Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brasil.

Alexandre Mazzanti ^*E-mail: alexamazza@yahoo.com.br. *Corresponding author

Serviço de Neurologia e Neurocirurgia, Hospital Veterinário Universitário (HVU), Departamento de Clínica de Pequenos Animais, Centro de Ciências Rurais (CCR), Universidade Federal de Santa Maria (UFSM), 97105-900, RS, Brasil. Universidade Federal de Santa Maria (UFSM)BrazilRS, BrazilServiço de Neurologia e Neurocirurgia, Hospital Veterinário Universitário (HVU), Departamento de Clínica de Pequenos Animais, Centro de Ciências Rurais (CCR), Universidade Federal de Santa Maria (UFSM), 97105-900, RS, Brasil.

http://orcid.org/0000-0002-1330-2142

E-mail: alexamazza@yahoo.com.br. ^*Corresponding author

DECLARATION OF CONFLICT OF INTERESTS

The authors declare no conflict of interest. The founding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.

AUTHORS’ CONTRIBUTIONS

All authors contributed equally for the conception and writing of the manuscript. All authors critically revised the manuscript and approved of the final version.

SCIMAGO INSTITUTIONS RANKINGS

Figures

Figures (3)

Thumbnail

Figure 1
Aortic thrombosis in a dog with chronic lymphocytic leukemia. 1A. Proprioceptive deficit of the right pelvic limb. 1B. Ultrasonic doppler for right femoral artery blood flow verification. 1C. Ultrasonography of the caudal abdominal aorta (near the trifurcation) and presence of a hyperechogenic mass (^*), partially obstructing the vessel lumen, characterizing aortic thrombosis. 1D. Color doppler evaluation of the same site of Figure 1C, demonstrating partial blood flow.

Thumbnail

Figure 2
Aortic thrombosis in a dog with chronic lymphocytic leukemia. 2A. Aortic artery, abdomen. A “tan to dark red”, irregular mass (thrombus) is observed within the lumen of the aorta and external iliac arteries. 2B. Liver, metastasis of chronic lymphocytic leukemia. Multiple white linear areas are observed on the capsular surface. 2C. Liver, metastasis of chronic lymphocytic leukemia. The neoplastic cells are infiltrated around the centrolobular vein and portal tracts. Additionally, some of these cells are seen within the sinusoids. The cells are small and resemble mature lymphocytes (inset). Hematoxylin and Eosin (HE), Obj 20x, (inset, 40x). 2D. Bone marrow, chronic lymphocytic leukemia. A population of monomorphic round neoplastic cells resembling lymphocytes and similar to the cells observed within the liver infiltrates the bone marrow. Cells are small, with scarce cytoplasm (inset). HE, Obj 20x, (inset, 40x).

Thumbnail

Figure 3
Aortic thrombosis in a dog with chronic lymphocytic leukemia. 3A. Neoplastic lymphocyte immunoreactivity to CD79 (B cell positivity). Immunohistochemistry, 10 X. 3B. The neoplastic cells did not immunoreact with CD3 (T cell negativity). Immunohistochemistry, 10 X.

Figure 1 Aortic thrombosis in a dog with chronic lymphocytic leukemia. 1A. Proprioceptive deficit of the right pelvic limb. 1B. Ultrasonic doppler for right femoral artery blood flow verification. 1C. Ultrasonography of the caudal abdominal aorta (near the trifurcation) and presence of a hyperechogenic mass (^*), partially obstructing the vessel lumen, characterizing aortic thrombosis. 1D. Color doppler evaluation of the same site of Figure 1C, demonstrating partial blood flow.

Figure 2 Aortic thrombosis in a dog with chronic lymphocytic leukemia. 2A. Aortic artery, abdomen. A “tan to dark red”, irregular mass (thrombus) is observed within the lumen of the aorta and external iliac arteries. 2B. Liver, metastasis of chronic lymphocytic leukemia. Multiple white linear areas are observed on the capsular surface. 2C. Liver, metastasis of chronic lymphocytic leukemia. The neoplastic cells are infiltrated around the centrolobular vein and portal tracts. Additionally, some of these cells are seen within the sinusoids. The cells are small and resemble mature lymphocytes (inset). Hematoxylin and Eosin (HE), Obj 20x, (inset, 40x). 2D. Bone marrow, chronic lymphocytic leukemia. A population of monomorphic round neoplastic cells resembling lymphocytes and similar to the cells observed within the liver infiltrates the bone marrow. Cells are small, with scarce cytoplasm (inset). HE, Obj 20x, (inset, 40x).

Figure 3 Aortic thrombosis in a dog with chronic lymphocytic leukemia. 3A. Neoplastic lymphocyte immunoreactivity to CD79 (B cell positivity). Immunohistochemistry, 10 X. 3B. The neoplastic cells did not immunoreact with CD3 (T cell negativity). Immunohistochemistry, 10 X.

How to cite

copy

Universidade Federal de Santa Maria Universidade Federal de Santa Maria, Centro de Ciências Rurais , 97105-900 Santa Maria RS Brazil , Tel.: +55 55 3220-8698 , Fax: +55 55 3220-8695 - Santa Maria - RS - Brazil
E-mail: cienciarural@mail.ufsm.br

Acompanhe os números deste periódico no seu leitor de RSS

Versão para download de PDF

PDF

Inglês

Versões e tradução automática

Versão original do texto

English

Tradução automática

Google Translator
Microsoft Translator

Como citar

RIS

BIBTEX

Outros formatos de citação e exportação:

SciELO - Scientific Electronic Library Online
Rua Dr. Diogo de Faria, 1087 – 9º andar – Vila Clementino 04037-003 São Paulo/SP - Brasil
E-mail: scielo@scielo.org

Leia a Declaração de Acesso Aberto

Métricas

Aortic thrombosis in a dog with chronic lymphocytic leukemia

PlumX

Mensagem

[1] E-mail: alexamazza@yahoo.com.br. ^*Corresponding author