Levamisole on the biochemical and hematological responses to parasitism by monogenoids in dog snapper

Oliveira, Bruno De Laquila; Souza, Rodrigo Matos de; Silva Filho, Jorge Pinto da; Ribeiro, Halysson Pena; Fioresi, Deusélio Bassini; Gomes, Levy de Carvalho; Fernandes, Luiz Fernando Loureiro

doi:10.1590/0103-8478cr20190013

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PARASITOLOGY • Cienc. Rural 49 (9) • 2019 • https://doi.org/10.1590/0103-8478cr20190013 linkcopy

Levamisole on the biochemical and hematological responses to parasitism by monogenoids in dog snapper

Efeito do levamisol na resposta bioquímica e hematológica ao parasitismo por monogenoides em dentão

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT:

The response of biochemical and hematological parameters were analyzed in dog snapper (Lutjanus jocu) grown in net cages, as well as for the specimens kept in the laboratory during an infestation by Neobenedenia melleni, and after treatment with freshwater bath and injectable application of levamisole. Significant changes were observed in N. melleni parasitized individuals, characterized by increased glucose and lactate levels, as well as a significant fish hematocrit reduction and leukocyte increase. Treatment with freshwater baths, concomitant with injectable levamisole application, showed therapeutic efficacy in several parameters after 14 days of treatment.

Key words:
aquaculture; biochemistry; hematology; Neobenedenia melleni; fish

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Universidade Federal de Santa Maria Universidade Federal de Santa Maria, Centro de Ciências Rurais , 97105-900 Santa Maria RS Brazil , Tel.: +55 55 3220-8698 , Fax: +55 55 3220-8695 - Santa Maria - RS - Brazil
E-mail: cienciarural@mail.ufsm.br

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[TFN1] Mean ± SD. Different letters (a, b or c) indicate a significant difference (p <0.05) between the groups.

[TFN2] Control: Fish cultured in the cage; Infected Fish: N. melleni-infected fish; Levamisole Control: collection 14 days post exposure to infected fish and application of the levamisole-free injection; Levamisole: collection 14 days post exposure to infected fish and administration of the levamisole injection.

Parameter	Control	Infected Fish	Levamisole Control	Levamisole	P value
---------------------------------------------------------------------------Hematological-------------------------------------------------------------------------
Hemoglobin (g dL⁻¹)	13.93±1.30 a	12.70±0.81 a	13.31±0.46 a	13.59±0.80 a	0.0997
Erythrocytes (10⁶ mm³)	2.6±0.52 ab	3.0±0.72 a	2.2±0.28 b	2.0±0.33 b	0.0068
Hematocrit (%)	45.7±4.5 a	35.5±7.0 b	32.6±5.4 b	40.75±4.5 a	0.0017
Leukocyte (10³ μL⁻¹)	47.07±18.86 b	117.0±30.56 a	76.15±36.52 ab	86.07±22.67 ab	0.0037
Neutrophils (%)	14.60±4.34 c	33.86±9.01 a	30.86±10.75 ab	18.14±12.02 bc	0.0047
Lymphocytes (%)	75.40±5.18 a	52.57±11.06 b	60.0±6.51 b	75.14±11.77 a	0.0003
Monocytes (%)	10.0±6.16 a	13.57±8.62 a	9.14±5.55 a	6.71±2.87 a	0.2597
Thrombocytes (10³ μL⁻¹)	29.48±10.64 b	55.17±8.54 a	51.12±6.68 a	37.39 ±9.21 b	0.0001
MCV (μL⁻¹)	182.54±47.90 a	121.65±21.54 b	150.42±36.88 ab	188.47±30.61 a	0.0059
MCH (%)	55.96±15.50 ab	45.31±13.68 b	61.10±8.14 ab	68.53±10.14 a	0.0109
MCHC (g dL⁻¹)	30.72±4.74 a	37.21±8.83 a	41.76±6.56 a	36.88±6.21 a	0.0870
----------------------------------------------------------------------------Biochemical--------------------------------------------------------------------------
Glucose (g dL⁻¹)	74.36±15.52 c	123.26±19.01 a	113.89±27.21 ab	85.83±16.24 bc	0.0010
Lactate (g dL⁻¹)	9.33±1.77 b	16.04±2.25 a	14.70±2.82 a	10.95±2.42 b	0.0002