The polysaccharide from Anacardium occidentale L. in the inflammatory phase of the cutaneous wound healing

The effect of the polysaccharide from Anacardium occidentale L. gum (POLICAJU) was evaluated in the inflammatory phase of the wound healing in Swiss mice (Mus musculus) (n=90), divided according to the employed treatment: Group I (NaCl 150mM), Group II (75mg ml-1 ascorbic acid) and Group III (emulsion containing 150mg ml-1 POLICAJU prepared in 75mg ml-1 ascorbic acid). An aseptic wound was produced in the dorsal thoracic area and each wound was treated in a single dose (200µl) soon after the accomplishment of the lesions. Daily, the wounds were submitted to the clinical and histopathological evaluation until the 6th day of postoperative (PO). In the 5th day PO, the Group III presented the signs oedema and hyperemia, in smaller percentile than the control groups. The results of area of the wound and percentile of contraction didn’t obtain statistical significance. The histopathological evaluation revealed, in the 6th day PO, that the Group III presented fibrovascular granulation tissue, while the control groups presented vascular granulation tissue. The use of POLICAJU propitiated to the animals of the treated group inflammatory signs less accentuated (oedema and hyperemia) in the inflammatory period, compatible with the normal wound healing process under the point of view histopathological, suggesting the possible clinical employment of the POLICAJU emulsion.

wound healing; inflammation; biomaterials; polysaccharide; Anacardium occidentale L.; cashew gum

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