The aim of this work was to study the use of levomepromazine, as an antiarrhythmogenic drug, in dogs anesthetized with sevoflurane. Twenty-one male and female healthy adult mixed breed dogs were used. The dogs were alocated in two groups, one with 11 (G1) and other with 10 (G2) animals. To G1 was administered, intravenously, 0.2ml/kg of 0.9% saline solution (placebo), followed by anesthetic induction with tiopental 15 minutes later. The intubation was proceeded, followed by imediate administration of sevoflurane at 2.5V% through semi-closed anesthetic circuit. After 20 minutes of the anesthetic induction, administration of 2% epinephrine solution had begun, in increasing doses of 1, 2, 3, 4 and 5mg/kg/min (M1 to M5, respectively), with increment of the doses at 10 minutes intervals. For G2 the same methodology was used, replacing the placebo by levomepromazine, at 1mg/kg. Electrocardiographic study was realized, in lead II, from the induction of the anesthesia. For statistical effect it was counted the total number of heart beats of non sinusal origin, coincident with each epinephrine dose. The numeric data were submitted to Analysis of Profile that demonstrated ventricular sustained arrhythmia, with the number of ectopic beatings growing from M1 to M3 and decreasing from M3 to M5, in G1. In G2, the ventricular sustained arrhythmia was observed only in M5. These results allowed the conclusion that levomepromazine minimizes ventricular epinephrine-induced arrhythmia in dogs anesthetized with sevoflurano.
levomepromazine; arrhythmia; epinephrine; sevoflurane; dogs
