Renal injury in female dogs with pyometra

Injúria renal em cadelas com piometra

Mariana da Silva Figueiredo Christina Malm Leonardo Dias Mamão Juliana de Oliveira Júlio César Cambraia Veado Mariana Pádua Costa Pâmela Cristina Lopes Gurgel Valente Rodrigo dos Santos Horta Marina Lopes Castro Aline Gomes de Castro Leila Sbaraini Eliana Matias de Souza About the authors

ABSTRACT:

Pyometra is a common disease in intact female dogs and can cause glomerulopathy and tubular injury. This study aimed to evaluate kidney injury in female dogs with pyometra, as well as progression of the injury during treatment and the markers of this condition. This study analyzed 20 intact female dogs with both clinical and sonographic diagnosis of pyometra. Dogs were treated with intravenous fluids and antibiotics, and an ovariohysterectomy was performed. The following parameters were assessed at eight separate time points: blood pressure; serum creatinine, phosphorus, and urea levels; urinalysis and urinary biochemical parameters [urinary gamma-glutamyl transferase (uGGT) and urinary protein-to-creatinine ratio (UPCR)]; glomerular filtration rate (GFR); and urine output. All dogs showed some degree of kidney injury at the time of pyometra diagnosis. This was transient in most animals, resolving with treatment of the pyometra. Measurement of uGGT and UPCR identified renal parenchymal injury, helping to determine the prognosis of the animals analyzed in the present study.

Key words:
kidney disease; kidney function; urinary GGT; urinary protein-to-creatinine ratio; glomerular filtration rate

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