The effects of oral administration of aqueous (NvH2O), methanolic (NvmeOH), buthanolic (Nvbut) and hexan (Nvhex) extracts, sequentialy obtained from 500g Nierembergia veitchii (dried plant) were compared with a vitamin D3 treated group and with a control group (saline), when administered during the pregnancy to Wistar rats (21 days). Weigth gain was reduced in dams treated with Nvhex, Nvbut and vitamin D3. In these groups it was observed a reduction in uterine implantations (9.3 ± 1.4, 9.6 ± 1.4 and 8.4 ± 1.4) when compared with the control (11.2 ± 0.4). The reduction could also be observed in the number of pups per litter (8.1 ± 1.3, 9.0 ± 1.5, 5.1 ± 1.7 and 10.3 ± 0.6), and in the weigth of pups at birth (2.1g ± 0.5, 2.9g ± 0.4, 1.9g ± 0.1 and 3.3g ± 0.1). We didn’t observe any difference betwen NvH2O, NvmeOH and control group. Macroscopicaly abnormalities were observed in some pups of Nvhex and Nvbut groups (0.1% and 0.2% respectively). The results of the skeleton avaliation showed 33.3%, 45%, 9.8% e 11.1% of abnormalities for NvH2O, NvmeOH, Nvbut and control group respectively. The most frequently observed abnormalities were found in the skull, and were: incomplete ossification of supraocciopital, interparietal, parietal, frontal and temporal.
calcinogenic plants; Nierembergia veitchii; vitamin D3; infertility; teratogenic effects
