Nandrolone Decanoate (ND), a hematopoietic system stimulant, is characterized as an accessible medicament for low-income pet owners. The aim of this research is to study the effect of different ND doses in the blood cytological parameters and the quantification and viability of the bone marrow (BM) mononuclear cells (MC), together with the labeling of CD34+ hematopoietic stem cells of healthy Wistar rats. Forty eight animals were randomly separated into six different groups of treatment, each composed of eight animals. These groups were divided in: G1 - control group (physiologic solution); G2 - diluent control (only vegetal oily vehicle); G3 - ND 0.42mg kg-1; G4 - ND 1.8mg kg-1; G5 - ND 4.6mg kg-1 and G6 - ND 10.0mg kg-1. The drug was weekly applied for three weeks. The hematologic and medullar analyzed parameters showed no significant difference between the groups, which may have been influenced by the BM conditions or by the applications frequency. According to the results obtained and according to the conditions under which this research was developed, it can be concluded that ND did not affect the blood cytological parameters, quantification and viability of MC and CD34+ labeling in healthy Wistar rats.
anabolic androgenic steroid; bone marrow stimulating factor; hematopoiesis; stem cells; mononuclear fraction; CD34+
