Medicine poisoning mortality trend by gender and age group, São Paulo State, Brazil, 1996-2012

Oliveira, Janessa de Fátima Morgado de; Wagner, Gabriela Arantes; Romano-Lieber, Nicolina Silvana; Antunes, José Leopoldo Ferreira

doi:10.1590/1413-812320172210.12782017

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ARTICLE • Ciênc. saúde colet. 22 (10) • Oct 2017 • https://doi.org/10.1590/1413-812320172210.12782017 copy

Medicine poisoning mortality trend by gender and age group, São Paulo State, Brazil, 1996-2012

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

This study looked into mortality due to medicinal drug poisoning by age, gender and intent among the population of the state of São Paulo. The adjusted time sequence of mortality due to drug poisoning was developed based on data available in the DATASUS Mortality Data System for 1996 to 2012. We checked the variables for magnitude and trends. We found an increase in adjusted mortality starting in 2005, and more so as of 2009, confirmed by a 95% CI for the average annual rate of change. (AARC) We did not find the same trend in overall mortality in the state (AARC = -0.22%, 95% CI = -1.12 - 0.69) for specific, external cause mortality (AARC = -3.14%, 95% CI = -4.75 - -1.49) and for mortality due to accidental drug poisoning (AARC=+9,76%, 95% IC = -12.16 – 37.14). The largest increase was found in intentional self-poisoning with medicinal drugs (AARC = +10.64%, 95% CI = 6.92 - 14.40), and among the younger subjects (largest magnitude). The trend in mortality due to drug poisoning in the State of São Paulo, the importance of intent and mortality among the younger population reiterate the need to implement control measures.

Mortality; Intoxication; Drugs

Year	Overall mortality (per 1,000 inhabitants)	Specific external cause mortality (per 10,000 inhabitants)
1997	6.7	9.4
1998	6.6	9.1
1999	6.6	9.5
2000	6.6	9.3
2001	6.3	9.0
2002	6.2	8.6
2003	6.2	8.1
2004	6.1	7.4
2005	5.8	6.8
2006	5.9	6.1
2007	6.1	5.8
2008	6.1	5.8
2009	6.2	5.8
2010	6.4	5.9
2011	6.5	5.8
2012	6.5	6.0
AARC (95% CI)	-0.22% (-1.12 – 0.69)	-3.14% (-4.75 – -1.49)

Year	Mortality due to accidental drug poisoning (per 1,000,000 inhabitants/year)			Death due to intentional drug self-poisoning (suicide) (per 1,000,000 inhabitants/year)			Death due to drug poisoning by intent (accidental, suicide and undertermined). (per 1,000,000 inhabitants/year)

	F	M	Total	F	M	Total	F	M	Total
1996	0.64	1.01	0.82	0.81	0.71	0.76	0.17	0.65	0.41
1997	0.45	1.23	0.83	0.34	0.58	0.46	0.17	0.12	0.14
1998	0.39	0.81	0.60	0.73	0.58	0.65	0.28	0.40	0.34
1999	0.44	0.79	0.61	0.66	0.62	0.64	0.28	0.45	0.36
2000	0.05	0.11	0.08	0.79	0.39	0.59	0.21	0.50	0.35
2001	0.10	0.43	0.27	1.20	0.76	0.98	0.57	0.65	0.61
2002	0.05	0.16	0.10	0.72	0.53	0.63	0.41	0.37	0.39
2003	0.00	0.05	0.03	0.91	0.53	0.72	0.76	0.26	0.52
2004	0.00	0.00	0.00	0.70	0.52	0.61	0.50	0.42	0.46
2005	0.10	0.25	0.17	0.82	0.86	0.84	1.07	0.81	0.94
2006	0.19	0.70	0.44	1.58	1.14	1.36	0.33	0.60	0.46
2007	0.19	0.49	0.34	1.50	1.48	1.49	0.80	0.69	0.74
2008	0.48	1.20	0.83	1.57	2.50	2.02	0.62	0.60	0.61
2009	0.28	1.04	0.65	1.74	1.79	1.76	0.61	0.65	0.63
2010	0.47	2.09	1.26	2.03	1.99	2.01	0.52	1.10	0.80
2011	0.75	3.80	2.24	2.20	2.57	2.38	0.84	1.33	1.08
2012	0.98	6.38	3.60	2.79	3.14	2.96	0.74	1.32	1.03
AARC (95% CI)	+3.84% (-12.25 – 22.88)	+11.87% (-11.05 – 40.71)	+9.76% (-12.16 – 37.14)	+10.11% (7.52 – 12.77)	+11.35% (5.32 – 17.72)	+10.64% (6.92 – 14.49)	+9.15% (5.45 – 12.97)	+8.76% (4.56 – 13.13)	+8.84% (6.72 – 11.00)

Year	X40+X60+Y10			X41+X61+Y11			X42+X62+Y12			X43+X63+Y13			X44+X64+Y14

	F	M	T	F	M	T	F	M	T	F	M	T	F	M	T
1996	0	1	1	7	4	11	0	4	4	0	0	0	21	31	52
1997	0	0	0	3	5	8	2	11	13	0	0	0	12	17	29
1998	1	0	1	10	5	15	1	1	2	0	1	1	13	24	37
1999	0	0	0	8	5	13	0	4	4	0	1	1	17	23	40
2000	1	0	1	7	5	12	2	2	4	0	0	0	10	11	21
2001	0	0	0	19	5	24	1	4	5	1	0	1	15	25	40
2002	1	0	1	11	7	18	0	3	3	1	0	1	10	10	20
2003	0	0	0	7	7	14	1	1	2	0	0	0	25	8	33
2004	0	0	0	11	10	21	0	0	0	0	0	0	13	8	21
2005	0	0	0	11	13	24	1	9	10	0	1	1	29	15	44
2006	0	0	0	20	13	33	1	13	14	0	0	0	23	23	46
2007	0	3	3	22	15	37	4	18	22	4	2	6	23	16	39
2008	2	0	2	24	16	40	8	35	43	3	1	4	19	34	53
2009	3	4	7	24	21	45	8	27	35	1	1	2	20	17	37
2010	0	1	1	20	19	39	12	44	56	1	1	2	31	39	70
2011	2	1	3	41	21	62	16	98	114	0	2	2	22	34	56
2012	2	3	5	47	45	92	21	139	160	0	4	4	27	30	57
Total (%)	12 (2)	13 (1)	25 (1.5)	292 (40)	216 (21)	508 (29)	78 (11)	413 (41)	491 (28)	11 (1)	14 (1)	25 (1.5)	330 (46)	365 (36)	695 (40)

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[1] Collaborations

JMF Oliveira designed and planned the study, gathered data, ran calculations and designed figures and tables, analyzed and interpreted the data and drafted the final version. GA Wagner and NS Romano-Lieber planned the study, contributed to a critical review of the content and helped approve the final version of the manuscript. JLF Antunes planned the study, ran calculations and data analysis, contributed to a critical review of the content, and helped approve the final version of the manuscript.