Structure, function and mechanism of edible fungus polysaccharides in human beings chronic diseases

LIU, Huijuan; LIU, Xiaoyi; XIE, Jiao; CHEN, Shuai

doi:10.1590/fst.111022

person Huijuan LIU *

schoolThe Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Guizhou Medical University, Guizhou, PR ChinaschoolGuizhou Provincial Engineering Research Center of Food Nutrition and Health, Guizhou Medical University, Guizhou, PR China

0000-0003-4643-8908

person Xiaoyi LIU

schoolThe Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Guizhou Medical University, Guizhou, PR China

person Jiao XIE *

schoolThe Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Guizhou Medical University, Guizhou, PR ChinaschoolGuizhou Provincial Engineering Research Center of Food Nutrition and Health, Guizhou Medical University, Guizhou, PR China

person Shuai CHEN

schoolDepartment of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Guizhou Medical University, Guiyang, China

person*Corresponding author:
emaillhj1101180716@163.com;
emaillxj4516@126.com

Conflict of interest

The authors declare that there are no competing interests associated with the manuscript.

groupsAuthor contributions

Conceptualization and funding acquisition, literature collection, writing - review & editing, drawing, H.L.; Project administration, resources, X.L.; Literature collection, writing - review & editing, J.X.; Literature collection, S.C.. All authors have read and agreed to the published version of the manuscript.

Polysaccharide source	Type of chronic diseases	Model	Mechanism	References
Ganoderma lucidum	Enteritis	Dextransulfate sodium salt-induced Wistar rats	Up-regulating the expressions of Ruminococcus 1, CCL5, Cd3e, Cd8a, Il-21r, Lck and Trbv; down-regulating the expressions of E. coli-Shigella, CCL3, Gro, IL-11, MHC-2 and Ptgs	(Xie et al., 2019)
Hericium erinaceus	Enteritis	Dextransulfate sodium salt-induced C57BL/6 mice	Up-regulating the expressions of T-SOD and Bacteroides; down-regulating the expressions of NO, MDA, MPO, IL-6, IL-1β, TNF-α, COX-2, iNOS, p-p65/p65, p-IκBα/IκBα, pAkt/Akt, p-p38/p38, p-ERK/ERK and p-JNK/JNK; reducing the numbers of Verrucobacterium, Actinomyces, Arthrobacter, Methylobacter, Succinyl Vibrio, Desulfovibrio .	(Ren et al., 2018)
Pleurotus djamor	Chronic renal failure	Chronic renal failure mouse model	Clearing DPPH and superoxide anion free radicals; enhancing the activities of SOD, GSH-Px and CAT; reducing the level of MDA; increasing the expression of HO-1 protein; reducing the levels of CREA, UA and UREA; inhibiting the up-regulation of IL-6 and TNF-α; reducing the levels of TGFβ1 and Smad3	(Li et al., 2021b)
Armillariella tabescens mycelia	Type 2 diabetes mellitus (T2DM)	A mouse model of insulin resistance in T2DM induced by high-fat diet combined with streptozotocin	Inhibiting the TXNIP/NLRP3 inflammasome pathway and activating the AMPK pathway	(Yang et al., 2020)
Hericium erinaceus	Enteritis	HOAc-induced SD rats; H₂O₂-induced Caco-2 cells	Up-regulating the levels of MMP, SOD, ATP, Bcl-2, IBA, GPR41, GPR43 and IgM; down-regulating the levels of MDA, TNF-α, IL-1, IL-6, ROS, p-p65, p65, caspase-3 and C3	(Shao et al., 2019; Wang et al., 2019a)
Poria cocos	Enteritis	TNBS-induced Kunming mice	Increasing the levels of IL-4, IL-10 and DHT; decreasing the levels of MPO, MDA, TNF-α, IL-6, L-1β, IL-12, IFN-γ, IL-2, IL-17, Hmgcs2, Fabp2, Hp, B4galnt2, B3gnt6, Sap and Ca1	(Liu et al., 2018a)
Poria cocos	Breast cancer	Human breast cancer MCF-7 cells	Inducing G1 cell cycle arrest and increasing Bax/Bcl-2 ratio	(Zhang et al., 2006)
Inonotus obliquus	Enteritis	Dextransulfate sodium salt-induced BALB/c mice	Up-regulating the levels of ZO-1, occludin, IL-4, IL-10, GATA-3, Foxp3 and p-STAT6; down-regulating the levels of p-STAT1, p-STAT3, IFN-γ, IL-17, T-bet and ROR-γt	(Chen et al., 2019)
Dictyophora indusiata	Enteritis	Dextransulfate sodium salt-induced C57BL/6 mice	Up-regulating the levels of GSH, HO^-, IL-10, Bcl-2, TJP1 and IRF4; down-regulating the levels of MDA, MPO, TNF-α, IL-6, IL-1β, IL-18, NLRP3, p-IκBα, p-STAT3, Bax, IRF5 and CD86	(Wang et al., 2019b)
Flammuliana velutipes	Enteritis	Dextransulfate sodium salt-induced SD rats	Up-regulating the levels of SOD and IVA; down-regulating the levels of MPO, NO, DAO, TLR4, NF-κB and p-p65	(Zhang et al., 2020a)
Antrodia cinnamomea	Lung cancer	Lung cancer cells	Inducing the proteasome-dependent degradation pathway; reducing TGFR protein level	(Lu et al., 2017)
Poria polysaccharide	Boost the immune system	Immunodeficient mice	Increasing the levels of serum IgA, IgG and IgM; Increasing the levels of IFN-γ and IL-4	(Zhang et al., 2014)