Vascular cognitive impairment in Pemphigus vulgaris: a case report

COMPROMETIMENTO COGNITIVO VASCULAR NO PÊNFIGO VULGAR: RELATO DE CASO

José Ibiapina Siqueira- Neto Paulo Marcelo Gondim Sales Emmanuelle Silva Tavares Sobreira Aline Miranda Limeira Heline Bessa Araujo Júnia Vieira dos Santos José Daniel Vieira de Castro About the authors

ABSTRACT

Pemphigus vulgaris is a systemic auto-immune medical condition that mainly manifests with changes in skin and vasculopathy. This is a case report of a 69-year-old male with confirmed histopathologic diagnosis of Pemphigus vulgaris presenting ulterior Cognitive Impairment, mostly in executive function. The patient was treated using steroids, immunomodulatory therapy, fluoxetine and galantamine. Neuropsychological testing and magnetic resonance (MRI) were performed. This is the first report of correlational cognitive impairment with Pemphigus vulgaris in the literature. Physicians should be aware of vascular causes for cognitive impairment in patients presenting auto-immune conditions.

Key words:
Pemphigus vulgaris; cognitive vascular impairment; neuropsychological testing; auto-immune diseases; dementia

RESUMO

Phemphigus vulgaris é uma condição médica sistêmica autoimune que principalmente se manifesta com alterações de pele e vasculopatia. Este é um caso de um homem de 69 anos com diagnóstico histopatológico de Phemphigus vulgaris apresentando posterior comprometimento cognitivo, predominante em funções executivas. O paciente foi tratado com esteroides, terapia imunomoduladora, fluoxetina e galantamina. Avaliação neuropsicológica e ressonância magnética foram realizados. Este é o primeiro relato correlacionando comprometimento cognitivo a pênfigo vulgar na literatura. Os clínicos devem estar cientes das causas vasculares para comprometimento cognitivo em pacientes se apresentando com condições autoimunes.

Palavras-chave:
Phemphigus vulgaris; comprometimento cognitivo vascular; avaliação neuropsicológica; doenças autoimunes; demência

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    » https://doi.org/10.1111/j.1468-3083.2011.04362.x

Publication Dates

  • Publication in this collection
    Jul-Sep 2012

History

  • Received
    10 June 2012
  • Accepted
    20 Aug 2012
Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento R. Vergueiro, 1353 sl.1404 - Ed. Top Towers Offices, Torre Norte, São Paulo, SP, Brazil, CEP 04101-000, Tel.: +55 11 5084-9463 | +55 11 5083-3876 - São Paulo - SP - Brazil
E-mail: revistadementia@abneuro.org.br | demneuropsy@uol.com.br
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