AIM: the cleft lip and palate are the most frequent human face deformities. It has a complex etiology with genetic and environmental factors. At the multidisciplinary services, a scientific research about deformities features is important in order to act at preventive levels. The purpose of this study was to evaluate the recurring risk of cleft lip and palate, among the affected population of the state of Paraná (Brazil), through morphologic and genetic indicators. METHODS: a sample of 17 cleft lip and palate affected individuals, not syndromic, males, selected from Center for Cleft Lip and Palate Assistance in Curitiba (PR), was tested to association between 2 morphologic features of cranial base - cranial base angle (Ba.S. Na) and anterior cranial base dimension (BCA) - and more frequent HLA types. The association coefficient between cranial base morphologic values (Ba.S.Na and BCA) proved to be low. RESULTS AND CONCLUSIONS: the association coefficient test for the values between Ba.S.Na and aloantigens HLA-B, HLA-DQ; BCA and aloantigens HLA-A, HLA-B, HLA-DQ and HLA-DR proved independence. The coefficient between Ba.S.Na and aloatigens HLA-A and HLA-DR showed weak dissociation. The outcome showed no association between phenotypic and genotypic characteristics tested at this sample, although wasn’t possible to confirm or not the possibility of utilization of them like risk indicators to cleft lip and/or palate at another population.
Craniofacial growth and development; Cleft lip and palate; Genetics
