Variable
Total
Progression
No
Yes
Baseline chromogranin A (CgA) (ng/mL)
Median [IQR]
316.50 [25.50-640.00]
382.00 [138.00-630.00]
312.00 [25.00-535.00]
Minimum-Maximum (n)
2.70-11,060.00 (20)
2.70-8,531.00 (9)
4.00-11,060.00 (11)
CgA (1-3 months)
Median [IQR]
206.00 [52.22-538.50]
90.00 [48.55-458.00]
259.00 [153.00-690.00]
Minimum-Maximum (n)
2.00-6,335.00 (12)
17.00-3,159.00 (7)
2.00-6,335.00 (5)
CgA (3-6 months)
Median [IQR]
139.00 [9.40-493.00]
93.10 [11.00-468.00]
325.50 [40.60-5,710.25]
Minimum-Maximum (n)
3.20-8,531.00 (11)
3.20-474.00 (5)
6.40-8,531.00 (6)
CgA (6-12 months)
Median [IQR]
87.00 [67.00-106.00]
114.00 [106.00-122.00]
58.00 [49.00-67.00]
Minimum-Maximum (n)
40.00-130.00 (4)
98.00-130.00 (2)
40.00-76.00 (2)
Baseline GGT (U/L)
Median [IQR]
72.50 [31.50-217.25]
74.00 [28.50-211.50]
71.00 [40.00-208.50]
Minimum-Maximum (n)
15.00-518.00 (26)
15.00-435.00 (11)
21.00-518.00 (15)
GGT (1-3 months)
Median [IQR]
47.00 [28.00-208.00]
36.50 [23.50-169.50]
74.00 [29.00-411.00]
Minimum-Maximum (n)
13.00-435.00 (25)
13.00-359.00 (12)
16.00-435.00 (13)
GGT (3-6 months)
Median [IQR]
189.00 [66.25-284.00]
123.50 [44.75-198.50]
292.00 [131.25-360.50]
Minimum-Maximum (n)
22.00-457.00 (12)
29.00-273.00 (6)
22.00-457.00 (6)
GGT (6-12 months)
Median [IQR]
75.00 [28.00-221.50]
148.50 [91.25-205.75]
75.00 [22.00-180.00]
Minimum-Maximum (n)
17.00-297.00 (7)
34.00-263.00 (2)
17.00-297.00 (5)
Baseline alkaline phosphatase (AP-U/L)
Median [IQR]
125.00 [99.50-161.00]
129.00 [91.50-159.00]
124.00 [105.50-161.00]
Minimum-Maximum (n)
50.00-431.00 (27)
50.00-378.00 (11)
65.00-431.00 (16)
AP (1-3 months)
Median [IQR]
125.50 [92.00-160.25]
120.00 [86.50-131.00]
129.00 [96.00-190.00]
Minimum-Maximum (n)
53.00-667.00 (26)
53.00-161.00 (11)
76.00-667.00 (15)
AP (3-6 months)
Median [IQR]
144.50 [116.75-171.00]
144.00 [105.50-145.00]
176.00 [119.50-254.50]
Minimum-Maximum (n)
91.00-614.00 (14)
91.00-156.00 (7)
99.00-614.00 (7)
AP (6-12 months)
Median [IQR]
135.00 [93.50-172.00]
177.50 [156.25-198.75]
95.00 [92.00-161.00]
Minimum-Maximum (n)
83.00-220.00 (7)
135.00-220.00 (2)
83.00-183.00 (5)
Baseline neutrophils
Median [IQR]
4,110.50 [2,376.25-4,965.25]
3,447.00 [2,348.75-4,120.00]
4,479.00 [2,769.25-5,656.50]
Minimum-Maximum (n)
929.00-10,331.00 (24)
1,749.00-4,283.00 (8)
929.00-10,331.00 (16)
Neutrophils (1-3 months)
Median [IQR]
3,534.50 [2,242.00-4,075.00]
2,740.00 [2,168.25-3,434.75]
3,848.00 [2,386.75-4,268.00]
Minimum-Maximum (n)
1,520.00-11,294.00 (22)
1,520.00-5,026.00 (8)
1,650.00-11,294.00 (14)
Neutrophils (3-6 months)
Median [IQR]
3,807.00 [2,813.00-4,773.50]
3,267.00 [2,881.25-4,493.50]
4,119.00 [2,431.25-4,621.00]
Minimum-Maximum (n)
929.00-5,859.00 (12)
2,693.00-5,007.00 (6)
929.00-5,859.00 (6)
Neutrophils (6-12 months)
Median [IQR]
3,564.00 [2,700.00-3,928.00]
2,700.00 [2,700.00-2,700.00]
3,746.00 [3,285.50-4,462.00]
Minimum-Maximum (n)
2,450.00-6,064.00 (5)
2,700.00-2,700.00 (1)
2,450.00-6,064.00 (4)
Baseline lymphocytes
Median [IQR]
1,811.00 [1,147.00-2,088.50]
2,088.50 [1,732.75-2,339.75]
1,708.00 [996.50-1,885.50]
Minimum-Maximum (n)
579.00-2,880.00 (23)
601.00-2,880.00 (8)
579.00-2,868.00 (15)
Lymphocytes (1-3 months)
Median [IQR]
1,778.00 [1,187.00-2,049.00]
1,526.50 [1,108.50-1,823.75]
1,903.00 [1,187.00-2,102.00]
Minimum-Maximum (n)
519.00-2,726.00 (21)
519.00-2,050.00 (8)
583.00-2,726.00 (13)
Lymphocytes (3-6 months)
Median [IQR]
1,820.50 [940.25-2,083.00]
1,531.00 [993.50-2,023.50]
1,840.50 [1,140.50-2,459.50]
Minimum-Maximum (n)
579.00-2,751.00 (12)
711.00-2,140.00 (6)
579.00-2,751.00 (6)
Lymphocytes (6-12 months)
Median [IQR]
1,662.00 [1,195.00-2,114.25]
1,241.00 [1,241.00-1,241.00]
2,083.00 [1,570.00-2,145.50]
Minimum-Maximum (n)
1,057.00-2,208.00 (4)
1,241.00-1,241.00 (1)
1,057.00-2,208.00 (3)
Baseline platelets
Median [IQR]
225,000 [196,500-330,500]
219,000 [200,500-300,000]
233,500 [193,000-362,000]
Minimum-Maximum (n)
109,000-560,000 (27)
109,000-354,000 (11)
140,000-560,000 (16)
Platelets (1-3 months)
Median [IQR]
209,000 [168,000-317,000]
197,000 [154,500-270,000]
274,500 [185,250-325,500]
Minimum-Maximum (n)
130,000-542,000 (25)
130,000-349,000 (11)
133,000-542,000 (14)
Platelets (3-6 months)
Median [IQR]
216,500 [173,000-259,500]
210,000 [167,000-248,000]
225,000 [184,000-255,000]
Minimum-Maximum (n)
142,000-391,000 (16)
142,000-391,000 (7)
146,000-341,000 (9)
Platelets (6-12 months)
Median [IQR]
162,000 [149,500-186,500]
170,000 [166,000-174,000]
156,000 [143,000-195,000]
Minimum-Maximum (n)
54,000-305,000 (7)
162,000-178,000 (2)
54,000-305,000 (5)
NLR (baseline)
Median [IQR]
2.18 [1.21-3.42]
1.72 [1.09-2.45]
2.90 [1.42-3.88]
Minimum-Maximum (n)
0.66-13.12 (23)
0.66-5.06 (8)
0.80-13.12 (15)
NLR (1-3 months)
Median [IQR]
1.98 [1.23-2.96]
2.20 [1.56-2.68]
1.98 [1.23-3.13]
Minimum-Maximum (n)
0.80-9.51 (21)
1.12-6.12 (8)
0.80-9.51 (13)
NLR (3-6 months)
Median [IQR]
2.14 [1.53-2.87]
2.44 [1.71-3.49]
1.87 [1.55-2.15]
Minimum-Maximum (n)
1.09-7.04 (12)
1.26-7.04 (6)
1.09-5.06 (6)
NLR (6-12 months)
Median [IQR]
1.98 [1.76-3.07]
2.18 [2.18-2.18]
1.78 [1.74-3.76]
Minimum-Maximum (n)
1.71-5.74 (4)
2.18-2.18 (1)
1.71-5.74 (3)
PLR (baseline)
Median [IQR]
162.42 [114.25-232.58]
133.45 [86.00-187.09]
168.62 [130.12-242.18]
Minimum-Maximum (n)
72.22-305.70 (23)
72.22-274.21 (8)
101.55-305.70 (15)
PLR (1-3 months)
Median [IQR]
154.93 [112.75-215.66]
154.78 [112.26-216.95]
179.35 [136.63-215.66]
Minimum-Maximum (n)
87.19-440.00 (21)
100.46-440.00 (8)
87.19-288.33 (13)
PLR (3-6 months)
Median [IQR]
181.23 [116.45-208.63]
194.58 [130.17-226.44]
148.49 [119.83-189.91]
Minimum-Maximum (n)
75.23-252.16 (12)
75.23-237.74 (6)
96.88-252.16 (6)
PLR (6-12 months)
Median [IQR]
115.87 [79.01-144.18]
143.43 [143.43-143.43]
88.32 [69.70-117.37]
Minimum-Maximum (n)
51.09-146.42 (4)
143.43-143.43 (1)
51.09-146.42 (3)
N: sample size; IQR: interquartile range; CgA: chromogranin A; GGT: gamma-glutamyltransferase; NLR: neutrophil-to-lymphocyte ratio; PLR: platelets-to-lymphocyte ratio.