Comparative analysis of somatostatin analog uptake between successfully irradiated and non-irradiated meningiomas

Abstract

Objective

To evaluate whether there is a significant difference in somatostatin analog uptake in meningiomas treated or not with radiation therapy.

Methods

A cross-sectional study was performed comparing measurements of somatostatin analog (⁶⁸Ga-DOTATATE) uptake in two independent groups of ten patients each - one consisting of patients with meningiomas previously treated with radiation therapy and another comprising patients who had never been submitted to radiation therapy. All patients underwent PET/CT and MRI scans in an interval shorter than 24 hours between exams.

Results

A total of 32 meningiomas from 20 patients were analyzed, all presenting significant somatostatin analog uptake in different degrees. The uptake levels of somatostatin analog were similar between the lesions treated or not with radiation therapy, and the mean values of SUV_max were 27.62 and 24.82, respectively (p=0.722). For SUV_mean, the values were 16.20 and 14.82, respectively (p=0.822).

Conclusion

Comparative analysis between the groups showed no significant differences in degree of somatostatin analog uptake in successfully irradiated and non-irradiated meningiomas.

Keywords:
Meningioma; Receptors; somatostatin; Positron-emission tomography; Radiotherapy