Long term persistence of coronavirus SARS-CoV-2 infection

Pinho, João Renato Rebello; Oliveira, Ketti Gleyzer de; Sitnik, Roberta; Maluf, Maira Marranghello; Rodrigues, Pedro Henrique Sebe; Santana, Rúbia Anita Ferraz; Welter, Eliane Rosseto; Irony, Ophir

doi:10.31744/einstein_journal/2021RC6369

Acessibilidade / Reportar erro

Brasil

Español English

sumário « anterior atual seguinte »

Sumário

Case Report • Einstein (São Paulo) 19 • 2021 • https://doi.org/10.31744/einstein_journal/2021RC6369 copy

Long term persistence of coronavirus SARS-CoV-2 infection

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

During the COVID-19 pandemic, a case of a long-term persistence of SARS-CoV-2 infection (from March 26 to May 20, 2020) was identified at a private hospital in São Paulo, SP, Brazil. The long-term positivity for SARS-CoV-2 in reverse transcriptase polymerase chain reaction tests of a patient diagnosed with COVID-19 suggests, at least part of patients who recovered, may still carry and transmit the SARS-CoV-2 virus. This fact emphasizes the importance of having at least two negative reverse transcriptase polymerase chain reaction test results for SARS-CoV-2. Serological assays were not particularly helpful in the case described, since the patient had very low antibodies titers at the end of the follow-up period. Low viral loads may not be detected by current molecular methods, leading to wrong conclusions regarding viral clearance.

Keywords:
COVID-19; SARS-CoV-2; Infecções Coronavírus; Coronavírus

Admission Days after onset of symptoms	March 24	March 29	April 10	April 26	May 3	May 4	May 11	May 20	Reference ranges
Admission Days after onset of symptoms	Day 5	Day 10	Day 22	Day 38	Day 45	Day 46	Day 53	Day 62	Reference ranges
Erythrocytes, 10⁶/uL	3.8^* * Results outside the reference range.	3.6^* * Results outside the reference range.	4.05	3.25^* * Results outside the reference range.	3.38^* * Results outside the reference range.	3.41^* * Results outside the reference range.	3.94	3.7^* * Results outside the reference range.	3.90-5.00
Hemoglobin, g/dL	12.4	11.7^* * Results outside the reference range.	13.0	10.7^* * Results outside the reference range.	10.7^* * Results outside the reference range.	11.2^* * Results outside the reference range.	12.8	11.8^* * Results outside the reference range.	12.0-15.5
Hematocrit,%	37.0	34.8^* * Results outside the reference range.	37.8	31.6^* * Results outside the reference range.	32.6^* * Results outside the reference range.	33.7^* * Results outside the reference range.	36.9	34.3^* * Results outside the reference range.	35.0-45.0
MCV, fL	97.4	96.7	93.3	97.2	96.4	98.8^* * Results outside the reference range.	93.7	92.7	82.0-98.0
MCH, pg	32.6	32.5	32.1	32.9	31.7	32.8	32.5	31.9	26.0-34.0
MCHC, g/dL	33.5	33.6	34.4	33.9	32.8	33.2	34.7	34.4	31.0-36.0
RDW, %	13.8	13.0	12.2	12.6	13.0	12.4	11.6	11.5	11.5-16.5
Leucocytes,mL	6,290	3,330^* * Results outside the reference range.	4,860	6,950	5,520	4,760	9,780	6,410	3,500-10,500
Neutrophils,mL	4,378	1,812	2,308	4,198	2,666	2,723	7,032	3,923	1,700-8,000
Eosinophils,mL	182	30^* * Results outside the reference range.	102	132	237	119	108	128	50-500
Basophils,mL	19	10	29	49	28	38	39	19	0-100
Lymphocytes,mL	1,088	1,129	2,070	2,029	2,131	1,461	2,083	1,731	900-2,900
Monocytes,mL	623	350	350	542	458	419	518	609	300-900
Platelets,mL	395,000	319,000	410,000	258,000	336,000	393,000	363,000	313,000	150,000-450,000
Mean platelet volume, fL	8.5	8.3	9.7	9.3	9.0	8.9	9.5	9.0	6.5-15.0
C-reactive protein, mg/L	2.3	6.2^* * Results outside the reference range.	<0.3	18.7^* * Results outside the reference range.	1.4	0.9	0.4	2.2	≤5.0

Instituto Israelita de Ensino e Pesquisa Albert Einstein Avenida Albert Einstein, 627/701 , 05651-901 São Paulo - SP, Tel.: (55 11) 2151 0904 - São Paulo - SP - Brazil
E-mail: revista@einstein.br

Acompanhe os números deste periódico no seu leitor de RSS

[1] Corresponding author: Roberta Sitnik, Avenida Albert Einstein, 627/701 – Morumbi Zip code: 05652-900 – São Paulo, SP, Brazil Phone: (55 11) 3747-2103 E-mail: robertas@einstein.br