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Original Article • Einstein (São Paulo) 14 (03) • Jul-Sep 2016 • https://doi.org/10.1590/S1679-45082016AO3641 linkcopy

Open-access Technical advances in flow cytometry-based diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria

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    ABSTRACT

    Objective:  To discuss the implementation of technical advances in laboratory diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria for validation of high-sensitivity flow cytometry protocols.

    Methods:  A retrospective study based on analysis of laboratory data from 745 patient samples submitted to flow cytometry for diagnosis and/or monitoring of paroxysmal nocturnal hemoglobinuria.

    Results:  Implementation of technical advances reduced test costs and improved flow cytometry resolution for paroxysmal nocturnal hemoglobinuria clone detection.

    Conclusion:  High-sensitivity flow cytometry allowed more sensitive determination of paroxysmal nocturnal hemoglobinuria clone type and size, particularly in samples with small clones.

    Keywords:
    Hemoglobinuria; paroxysmal/diagnosis; Flow cytometry/methods; Technological development

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