Finucane e Merce3232 Finucane A, Mercer SW. An exploratory mixed methods study of the acceptability and effectiveness of Mindfulness-Based Cognitive Therapy for patients with active depression and anxiety in primary care. BMC Psychiatry. 2006;6:14.
|
5/11 |
13 individuals with MDD |
GI - *MBCT |
Depression BDII Mean (SD) |
(03 male, 10 female) |
|
Baseline to 8-week = 35.73(8.69) to 17.82(14.59) |
(18 to 65 years old) |
|
Anxiety BAI Mean (SD) |
(ICD-10) |
|
Baseline to 8-week = 32.00(12.50) to 20.51(17.08) |
Kenny e Willians3333 Kenny MA, Williams JM. Treatment-resistant depressed patients show a good response to Mindfulness-based Cognitive Therapy. Behav Res Ther. 2007;45(3):617-25.
|
5/11 |
46 individuals with MDD |
GI - *MBCT |
BDI for suicidal Mean (SD)
|
(20 male, 59 female) |
- moderate (n=26) (BDI ≤ 24) and, severe (n=29) (BDI ≥ 25) |
- With thoughts of death and suicide = Baseline to 8-week = 27.2(10.6) to 14.8(10.6) |
(17 to 61 years old) |
- With and Without thoughts of death and suicide |
- Without thoughts of death and suicide = Baseline to 8-week = 20.2(5.7) to 12.8(7.8) |
(DSM-IV - SCID) |
- Homework involved around 1 h per day of meditation or yoga, and other related formal and informal practices for the 8 weeks |
Depression BDI Mean (SD) p |
(patients who were currently actively depressed, and who had not responded fully to standard treatments) |
|
- moderate (BDI ≤ 24) = Baseline to 8-week = 17.2(4.3) to 11.5(7.8) |
|
|
- severe (BDI ≥ 25) = Baseline to 8-week = 33.2(6.4) to 17.1(11.2) |
|
|
Total = Baseline to 8-week = 24.39(9.8) to 13.9(9.7) p.00 |
Barnhofer et al.3434 Barnhofer T, Crane C, Hargus E, Amarasinghe M, Winder R, Williams JM. Mindfulness-based cognitive therapy as a treatment for chronic depression: A preliminary study. Behav Res Ther. 2009;47(5):366-73.
|
5/11 |
28 individuals with MDD |
GI - (14) *MBCT |
Depression BDII Mean (SD) p |
(19 female, 9 male) |
GII - (14) TAU |
MBCT - Baseline to 8-week = 29.36(9.66) to 17.62(10.94) p.00 |
(18 to 65 years old) |
|
TAU - Baseline to 8-week = 31.32(10.79) to 28.86(12.97) ns |
(DSM-IV - SCID) |
|
Suicide Ideation BSS Mean (SD) |
|
|
MBCT - Baseline to 8-week = 2.21(2.45) to 1.14(1.79) |
|
|
TAU - Baseline to 8-week = 2.78(2.08) to 2.42(2.53) |
|
|
Group did not meet criteria for a full episode of Major Depression at post-assessment
|
|
|
MBCT - 70% |
|
|
TAU - 18% |
Bondolfi et al.3535 Bondolfi G, Jermann F, der Linden MV, Gex-Fabry M, Bizzini L, Rouget BW, et al. Depression Relapse prophylaxis with Mindfulness-Based Cognitive Therapy: replication and extension in the Swiss health care system. J Affect Disord. 2010;122(3):224-31.
|
8/11 |
55 individuals with MDD |
GI - (27) *MBCT + TAU |
Antidepressant medication was reinstated in
|
(43 female, 12 male) |
GII - (28) TAU |
MBCT+TAU - 36% |
(18 to 65 years old) |
Follow-up = 14 months |
TAU- 31% |
(DSM-IV - SCID) |
|
Time to relapse
|
(limited the inclusion to patients with 3 or more previous episodes; least three past depressive episodes (2 episodes in the past 5 years and at least one in the past 2 years); remission for at least 3 months at time of enrolment; history of treatment with antidepressants but to currently be off medication for at least 3 months before enrolment) |
|
MBCT+TAU - 29 weeks |
|
|
TAU - 10 weeks |
|
|
Delay until onset of antidepressant medication
|
|
|
MBCT+TAU - 204 day |
|
|
TAU - 111 day |
|
|
One or more visit for counselling, psychotherapy or support from professional mental health staff was undertaken
|
|
|
MBCT+TAU - 46% |
|
|
TAU - 55% |
Segal et al.3636 Segal ZV, Bieling P, Young T, MacQueen G, Cooke R, Martin L, et al. Antidepressant monotherapy vs sequential pharmacotherapy and mindfulness-based cognitive therapy, or placebo, for relapse prophylaxis in recurrent depression. Arch Gen Psychiatry. 2010;67(12):1256-64.
|
9/11 |
84 individuals with MDD |
GI - (28) m-ADM (To maintenance antidepressant medication) |
Rate of relapse
|
(48 female, 36 male) |
GII - (26) *MBCT (To discontinuation antidepressant medication + MBCT) |
M-ADM - 27% |
(18 to 65 years old); |
GIII - (30) PLA (To discontinuation antidepressant medication + placebo and clinical management) |
MBCT - 28% |
(DSM-IV - SCID) |
(Patients in both the placebo and MBCT conditions had their medication tapered gradually, during a 4-week period, via placebo substitution and reduced pill count, respectively, at the recommended rate for their specific medication to minimize the risk of discontinuation syndrome) |
PLA - 71% |
(disorder with a minimum of 2 past episodes and ≥ 16 Hamilton Rating Scale for Depression) |
Follow-up = 18 months |
Days to reach remission, mean (SD)
|
|
|
M-ADM - 80.1(60.0) |
|
|
MBCT - 68.1(51.9) |
|
|
PLA - 90(57.8) |
Bieling et al.4242 Bieling PJ, Hawley LL, Bloch RT, Corcoran KM, Levitan RD, Young L, et al. Treatment-specific changes in decentering following mindfulness-based cognitive therapy versus antidepressant medication or placebo for prevention of depressive relapse. J Consult Clin Psychol. 2012;80(3):365-72.
|
6/11 |
84 individuals with MDD |
GI - (28) ADM (To maintenance antidepressant medication) |
Rumination Mean (SD) |
(52 female, 32 male) |
GII - (26) *MBCT (To discontinuation antidepressant medication + MBCT) |
MBCT - Baseline to 8-week = 17.40(4.10) to 17.73(3.91) ns |
(18 to 65 years old) |
GIII - (30) PLA (To discontinuation antidepressant medication + placebo) |
ADM - Baseline to 8-week = 19.12(2.20) to 19.33(2.66) ns |
(DSM-IV) |
Follow-up = 6 months |
PLA - Baseline to 8-week = 19.12(2.83) to 19.05(3.36) ns |
Van Vugt et al.22 Van Vugt MK, Hitchcock P, Shahar B, Britton W. The effects of mindfulness-based cognitive therapy on affective memory recall dynamics in depression: a mechanistic model of rumination. Front Hum Neurosci. 2012;6:257.
|
9/11 |
45 individuals with MDD |
GI - (19) control |
Depression BDI Mean p |
(39 female, 06 male) |
GII - (26) *MBCT |
MBCT - Baseline to 8-week = 9.1 to 6.5 p.01 |
(24 to 64 years old) |
|
Positive words (%) |
(DSM-IV - SCID) |
|
MBCT - Baseline to 8-week = 28.9 to 33.5 |
To maintenance antidepressant medication |
|
Control - Baseline to 8-week = 27.3 to 30.5 |
|
|
Negative words (%) |
|
|
MBCT - Baseline to 8-week =27.2% to 27.4 |
|
|
Control - Baseline to 8-week = 24.0 to 32.0 |
|
|
Anxiety (STAI-Y1) Mean (SD) |
|
|
MBCT - Baseline to 8-week = 53.4(10.9) p/ 50.7 (11.12) p.05 |
Batink et al.4343 Batink T, Peeters F, Geschwind N, van Os J, Wichers M. How does MBCT for depression work? Studying cognitive and affective mediation pathways. PLoS One. 2013;8(8):e72778.
|
8/11 |
130 individuals with MDD |
GI - (64) *MBCT + TAU |
Rumination Mean (SD) |
(98 female, 32 male) |
GII - (66) TAU |
MBCT + TAU- Baseline to 8-week = ≤2 - 7.8(8.5) to - 8.1(8.4) ns |
(24 to 64 years old) |
Randomization was stratified according to number of depressive episodes (≤2 MDE vs ≥3 MDE) |
MBCT + TAU- Baseline to 8-week = ≤3 - 7.8(8.5) to - 7.5(8.8) ns |
(DSM-IV - SCID) |
|
TAU - Baseline to 8-week = ≤2 -2.7(7.7) to - 1.9(6.9) ns |
To maintenance antidepressant medication |
|
TAU - Baseline to 8-week = ≤3 -2.7(7.7) to - 3.7(8.6) ns |
Munshi et al.3737 Munshi K, Eisendrath S, Delucchi K. Preliminary long-term follow-up of Mindfulness-based cognitive therapy-induced remission of depression. Mindfulness (N Y). 2013;4(4):354-61.)
|
5/11 |
18 individuals with MDD |
GI - *MBCT |
Depression (BDI) Mean p |
(13 female, 05 male) |
Follow-up = 48.7 months |
Baseline to 8-week to follow-up -18.78 to 5.33 to 5.89 p.00 |
(24 to 81 years old) |
|
Rumination (RRS) Mean |
(DSM-IV - SCID) |
|
Baseline to 8-week to follow-up - 49.28 to 44.41 to 40.11 p.00 |
|
|
Anxiety (STAI-Y1) Mean |
|
|
Baseline to 8-week to follow-up - 44.22 to 31.56 to 31.22 p.00 |
Omidi et al.3838 Omidi A, Mohammadkhani P, Mohammadi A, Zargar F. Comparing mindfulness based cognitive therapy and traditional cognitive behavior therapy with treatments as usual on reduction of major depressive disorder symptoms. Iran Red Crescent Med J. 2013;15(2):142-6.
|
8/11 |
90 individuals with MDD |
GI - (30) *MBCT |
Depression (BSI) Mean (SD) |
(60 female, 30 male) |
GII - (30) CBT (traditional Cognitive Behavior Therapy) |
MBCT - Baseline to 8-week - 2.05(0.84) to 0.79(0.63) |
(18 to 45 years old) |
GIII - (30) TAU |
CBT - Baseline to 8-week - 2.18(0.57) to 0.79(0.51) |
(DSM-IV - SCID) |
|
TAU - Baseline to 8-week - 2.18(0.85) to 1.96(0.86) |
|
|
Brief Symptom Inventory (BSI) Mean (SD) |
|
|
MBCT - Baseline to 8-week - 1.62(0.56) to 0.72(0.46) |
|
|
CBT - Baseline to 8-week - 1.79(0.47) to 0.72(0.26) |
|
|
TAU - Baseline to 8-week - 1.79(0.50) to 1.59(0.52) |
Schoenberg e Speckens3939 Schoenberg PL, Speckens AE. Modulation of induced frontocentral theta (Fm- ?) event-related (de-)synchronisation dynamics following mindfulness-based cognitive therapy in Major Depressive Disorder. Cogn Neurodyn. 2014;8(5):373-88.
|
7/11 |
51 individuals with MDD |
GI - (25) control |
Depression IDS Mean (SD)p |
(60 female, 30 male) |
GII - (26) *MBCT |
MBCT - Baseline to 8-week - 27.3(9.4) to 19.3(9.3) p.02 |
(21 to 65 years old) |
|
Control - Baseline to 8-week - 25.1(12.3) to 25.3(13.2) ns |
(DSM-IV-TR) |
|
Response patterns towards feelings of sadness/depression (RRS) Mean (SD)p |
|
|
MBCT - Baseline to 8-week - 60.6(11.9) to 55.1(11.0) p.03 |
|
|
Control - Baseline to 8-week - 60.2(13.2) to 59.7(13.8) ns |
Williams et al.4040 Willians JM, Crane C, Barnhofer T, Brennan K, Duggan DS, Fennell MJ, et al. Mindfulness-based cognitive therapy for preventive relapse in recurrent depression: a randomized dismantling trial. J Consult Clin Psychol. 2014;82(2):275-86.)
|
6/11 |
255 individuals with MDD |
GI - (99) *MBCT |
Relapse to Major Depression (%) |
(198 female, 57 male) |
GII - (103) **CPE (cognitive psychological education) |
MBCT - 46% |
(18 to 70 years old) |
GIII - (53) TAU |
CPE - 50% |
(DSM-IV - SCID and suicidal feelings and at least one other symptom of depression, which together were not attributable to bereavement, substances, or medical condition, but were impairing functioning) |
Follow-up = 6 months |
TAU - 53% |
|
|
Antidepressant use (%) |
|
|
MBCT - 18% |
|
|
CPE - 13% |
|
|
TAU -21% |
|
|
Looked for a psychiatrist (%) |
|
|
MBCT - 10% |
|
|
CPE - 9% |
|
|
TAU - 11% |
Kuyken et al.4141 Kuyken W, Hayes R, Barrett B, Byng R, Dalgleish T, Kessler D, et al. Effectiveness and cost-effectiveness of mindfulness-based cognitive therapy compared with maintenance antidepressant treatment in the prevention of depressive relapse or recurrence (PREVENT): a randomised controlled trial. Lancet. 2015;386(9988):63-73.
|
10/11 |
424 individuals with MDD |
GI = (212) *MBCT-TS = mindfulness + support to taper or discontinue their maintenance antidepressant medication |
Depression BSII Mean (SD) |
(325 female, 99 male) |
GII = (212) m-ADM |
MBCT-TS
|
(20 to 79 years old) |
Follow-up = 24 months |
Baseline 13.8(12.4) to 1 month 9.9(9.7) to 9 months 11·0 (10·5) to 12 months 10.7(10.0) to 18 months 11.7(10.6) to 24 months 11.6(10.9) ns |
|
|
m-ADM
|
|
|
Baseline 14.4(10.1) to 1 month 13.9(10.9) to 9 months 10.5(9.7) to 12 months 11.3(9.2) to 18 months 11.3(10.7) to 24 months 11.9(10.7) ns |
Shallcross et al.1313 Shallcross AJ, Gross JJ, Visvanathan PD, Kumar N, Palfrey A, Ford BQ, et al. Relapse prevention in major depressive disorder: mindfulnessbased cognitive therapy versus an active control condition. J Consult Clin Psychol. 2015;83(5):964-75.
|
8/11 |
51 individuals with MDD |
GI - (29) *MBCT |
Depression BDII Mean (SD) |
(38 female, 13 male) |
GII - (22) **ACC active control condition |
MBCT
|
(18 to 65 years old) |
Follow-up = 12 months |
Baseline 12.1(7.5) to 1 month 11.9(7.2) to 6 months 8.2(6.9) to 12 months7.0(6.1) |
(DSM-IV - SCID) |
|
ACC
|
|
|
Baseline 11.9(6.6) to 1 month 7.1(6.4) to 6 months 6.2(5.7) to 12 months 7.2(6.0) |
|
|
Relapse to Major Depression
|
|
|
MBCT - 32.6% |
|
|
ACC - 30.4% |
|
|
Antidepressant use
|
|
|
MBCT Baseline 30.4 to 1 month 28,1 |
|
|
ACC Baseline 26.1to 1 month 22.2 |