| Von Korff et al. (2011) 10 |
To evaluate the effectiveness of integrated care for chronic physical diseases and depression in reducing disability and improving quality of life. |
Individuals with diabetes or coronary heart disease, or both, and depression |
USA. |
15 items |
Self-management support |
Physicians and nurses |
Diabetes or cardiovascular diseases |
| Jenkins et al. (2013) 11 the rate of accurate routine clinic detection of mental disorder was greater than 0 in 5% versus 0% of the intervention and control groups respectively, in both the intention to treat analysis (p = 0.50 |
To examine the impact of mental health in service training on routine detection of mental disorder in the clinics and on client outcomes. |
Adults treated at a primary health care unit. |
Kenya |
36 items |
Training for healthcare professionals |
Local health workers |
Mental disorders |
| Choi et al. (2014) 12 |
To report longer term outcomes of tele-PST for both depression and disability. |
Non-Hispanic White, Black/African American, and Hispanic homebound adults (age≥50) with depression |
USA. |
12 items |
Monitoring by telerehabilitation or face-to-face |
Social workers |
Depression |
| Alegría et al. (2014) 13 |
To evaluate treatment effectiveness of telephone or face-to-face delivery of a cognitive behavioral therapy and care-management intervention for low-income Latinos with depression. |
Latino primary care patients with moderate or severe depressive symptoms |
USA and Puerto Rico |
No information |
Engagement and Counseling (telephone and face to face); usual care |
Physicians |
Depression |
| Kang et al. (2015) 14 300 were randomized to a 24-week double-blind trial of escitalopram or placebo, while the remaining 146 received conventional medical treatment only (MTO |
To evaluate the result of screening for treatment and subsequent treatment of depression on one-year psychiatric outcomes in ACS. |
Individuals who developed acute coronary syndrome, resulting in hospitalization |
Korea |
12 items |
Escitalopram; Placebo. |
Physicians and nurses |
Depression |
| Jordans et al. (2015) 15 |
To evaluate the effectiveness of adding community-based counsellor-delivered psychological interventions for adults who initiated mhGAP-based primary care services for depression and alcoholism in Nepal. |
Adults (age≥16 years) with depression and suffering from alcoholism. |
Nepal |
12 items |
mhGAP-based intervention; Additionally received HAP or CAP. |
Local health professionals and counselors |
Depression and alcoholism |
| Kästner et al. (2015) 16 |
To evaluate the effect of a previously implemented AO model using patient- and clinician-ratings. |
Adult patients with a schizophreniform disorder and a maximum of 60 points on the Global Assessment of Functioning Scale. |
Germany |
12 items |
Assertive Community Treatment, Intensive Case Management, Integrated Care, or Assertive Outreach; Treatment as usual. |
Nurses and physicians |
Schizophrenia |
| Robinson et al. (2015) 17 |
To investigate the value of exergaming using the Wii Fit™ for people with Multiple Sclerosis. |
Adults with clinical diagnosis of multiple sclerosis, self-reported ability to walk 100 meters with or without resting with the use of a walking stick or crutch. |
UK |
12 items |
Balance training using Nintendo Wii Fit™ (exergaming); Traditional balance training (no exergaming); No intervention. |
Physical Therapist |
Multiple sclerosis |
| Rahman et al. (2016) 18 SETTING, AND PARTICIPANTS: A randomized clinical trial was conducted from November 1, 2014, through January 28, 2016, in 3 primary care centers in Peshawar, Pakistan, that included 346 adult primary care attendees with high levels of both psychological distress and functional impairment according to the 12-item General Health Questionnaire and the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0 |
To tests the effectiveness of a multicomponent behavioral intervention delivered by lay health workers to adults with psychological distress in primary care settings. |
Adult primary care attendees with high levels of both psychological distress and functional impairment. |
Pakistan |
12 items |
Empirically supported problem-solving strategies, behavioral activation, strengthening social support, and stress management; Treatment as usual. |
Physicians and other unspecified healthcare professionals |
Post-traumatic stress disorder |
| Medina Vidales et al. (2017) 19 |
To evaluate the efficacy of Brief Psychoeducation Intervention to reduce time being ill, prevent relapses, and alleviate symptoms for people with bipolar disorder. |
Adults (aged 18–29 years), who had been diagnosed with bipolar disorder. |
Mexico |
No information |
Psychoeducation plus medication; Treatment as usual – pharmacological |
Graduate research students of the last year of Psychology. |
Bipolar disorder |
| Nadkarni et al. (2017) 20 only a small fraction of people globally receive these treatments because of poor access in routine primary care. We assessed the effectiveness and cost-effectiveness of Counselling for Alcohol Problems (CAP) |
To evaluate the effects of the intervention on alcohol consumption 12 months after enrollment, the cost-effectiveness of the intervention, for whom and under what circumstances the intervention works, and mediation of these results by the patient’s ‘’readiness to change’’ evaluated at three months. |
Males aged 18 to 65 who binge drink. |
India |
No information |
Consultation with the PHC physician and information on when and where to find psychiatric service; Manual psychological treat ment delivered in three phases in a maximum of four sessions. |
Physicians and counselors (no mental health experience and high school graduate) |
Alcoholism |
| Richard et al. (2017) 21 |
To test the effectiveness of a new five-session behavioral treatment called Problem Management Plus that lay community workers can be taught to deliver. |
Female adults who had experienced gender-based violence. |
Kenya |
12 items |
Problem Management Plus (PM+); Usual care with nurses. |
Nurses and community workers |
Post-traumatic stress disorder |
| Teixeira-Machado et al. (2017) 22 |
To investigate the effect of dance in the functioning and psychosocial adjustment of young subjects with cerebral palsy. |
Young subjects with cerebral palsy. |
Brazil |
No information |
Kinesiotherapy; Dance. |
Physical Therapists |
Cerebral Palsy |
| Weobong et al. (2017) 23 a brief behavioural intervention delivered by lay counsellors, enhanced remission over 3 months among primary care attendees with depression in peri-urban and rural settings in India. We evaluated the sustainability of the effects after treatment termination, the cost-effectiveness of HAP over 12 months, and the effects of the hypothesized mediator of activation on clinical outcomes. Methods and findings: Primary care attendees aged 18–65 years screened with moderately severe to severe depression on the Patient Health Questionnaire 9 (PHQ-9 |
To assess the stability of HAP’s effects on depression at 12 months post-enrolment, the mediation of the clinical outcomes by patient activation assessed at three months, and the cost-effectiveness of the intervention. |
Adult patients at a primary health center with a probable diagnosis of moderately severe to severe depression. |
India |
No information |
Enhanced routine care; Healthy activity programmed. |
Physicians, community counselors |
Depression |
| Alegría et al. (2019) 24 |
To test the acceptability and effectiveness of a disability prevention intervention, Positive Minds-Strong Bodies, offered by paraprofessionals to mostly immigrant older adults in four languages. |
Adults, not seeking disability prevention services but eligible per elevated mood symptoms and minor to moderate physical dysfunction. |
USA and Puerto Rico |
No information |
Routine care; Cognitive-behavioral therapy plus strengthening exercises. |
Exercise trainers and clinical supervisors |
Post-traumatic stress disorder |
| Anjara et al. (2019) 25 |
To compare patient outcomes following primary care in mental health treatment by GPs and Nurses additionally trained in the WHO mhGAP or a Clinical Psychologist co-located in a Puskesmas. |
Adult primary care patients |
Indonesia |
36 items |
Psychosocial and/or pharmacological interventions; Psychosocial interventions. |
General practitioners and nurses |
Mental disorders |
| Hounsome et al. (2019) 26 |
To test the hypothesis that community-based treatment of podoconiosis lymphoedema reduces the frequency of acute dermato-lymphangio-adenitis episodes and secondarily that it improves other clinical, social, and economic outcomes. |
Adults with a diagnosis of at least stage 2 podoconiosis (persistent lymphoedema). |
Ethiopia |
12 items |
Training in foot hygiene, skin care, dressings, exercise, and use of socks and shoes; Followed quarterly for data collection but did not receive intervention for 12 months (delayed intervention). |
Not specified |
Podoconiosis lymphoedema |
| Khan et al. (2019) 27 |
The feasibility trial was to evaluate the feasibility and acceptability of the locally adapted Problem Management Plus Group intervention for women in the conflict affected settings in Swat, Pakistan. |
Female adults with suspected psychological distress. |
Pakistan |
12 items |
Problem management plus (PM+); Treatment as usual. |
Psychiatrists and psychologists |
Mental disorders |
| Rahman et al. (2019) 28 |
To establish the effectiveness of a brief psychological intervention group for women in a conflict-affected setting in rural Swat, Pakistan. |
Female adults in the community |
Pakistan |
12 items |
Problem management plus (PM+); Treatment as usual. |
Graduates |
Post-traumatic stress disorder |
| Choi et al. (2020) 29 |
To test the acceptability and effectiveness of a lay-coach-facilitated, videoconference, short-term behavioral activation (Tele-BA) intervention for improving social connectedness among homebound older adults. |
Individuals with ≥50 years and confirmation of loneliness and no-to-mild depressive symptoms. |
USA |
12 items |
Tele-BA as Treatment Condition; Tele-Friendly Visiting as Active Control. |
Not specified |
Older people |
| Kladnitski et al. (2020) 30 |
To examine the efficacy of transdiagnostic internet-delivered cognitive behavioral therapy (iCBT), mindfulness-enhanced iCBT, and stand-alone online mindfulness training compared with a usual care control group (TAU) for clinical anxiety and depression. |
Adult individuals with a diagnosis of depressive and/or anxiety disorder. |
Australia |
12 items |
The iCBT program; The Mindfulness-Enhanced iCBT program; The Mindfulness Training (iMT) program; The TAU group. |
Psychiatrists |
Depression and anxiety |
| Maurus et al. (2020) 31 |
To evaluate the feasibility and efficacy of a newly developed 12-week resistance program according to current recommendations of the WHO and the American College of Sports Medicine. |
Adult individuals with diagnosis of schizophrenia. |
Germany (Munich) |
36 items |
Resistance training for schizophrenia patients; Balance and tone training. |
Not specified |
Schizophrenia |
| Shaili et al. (2020) 32 |
To assess the efficacy of a five-session version of Skills Training in Affective and Interpersonal Regulation (STAIR) among veterans obtaining treatment in primary care. |
Patients receiving treatment at a large Veterans Affairs medical center in the Western United States. |
USA |
WHODAS domains: Getting along with people, Life activities, and Participation in society |
STAIR-PC; Usual treatment. |
Mental health professionals, health technicians |
War veterans |
| Akhtar et al. (2021) 33 |
To test the safety and acceptability of GroupPM+ in a refugee camp and to identify areas for adaptation in preparation for a definitive RCT. |
Syrian adults, parent of a child aged 10–16 years, experiencing psychological distress. |
Jordan |
12 items |
Problem management plus (PM+); Enhanced treatment as usual. |
Bachelor’s degree in Psychology or a Health-related field |
Post-traumatic stress disorder |
| Hamdani et al. (2021) 34 |
To evaluate the effectiveness of adding PM+ for CMDs to routine care in a specialized mental health care facility in Pakistan. |
Adult outpatient department attendees, referred for psychological support for depression, anxiety, and stress. |
Pakistan |
12 items |
Problem Management plus (PM+); Treatment‑as‑Usual (TAU). |
Master’s degree in Psychology and Psychiatry |
Mental disorders |
| de Pinho et al. (2021) 35 1-week post-treatment and at follow-up 3 months after treatment. The primary outcome measure was psychotic symptoms based on the Psychotic Symptom Rating Scales (PSYRATS |
To evaluate the efficacy of metacognitive group training in reducing psychotic symptoms and improving cognitive insight and functions in people with schizophrenia. |
Adult patients with schizophrenia |
Portugal |
12 items |
Metacognitive training; Treatment as usual. |
Psychiatric and mental health nurses |
Schizophrenia |
| Asher et al. (2022) 36 masked to the intervention or control label, used a computer programme to randomly choose the allocation sequence from the set of optimal ones. We recruited adults with disabling illness as a result of schizophrenia. The subdistricts were eligible for inclusion if they included participants that met the eligibility criteria. Researchers recruiting and assessing participants were masked to allocation status. Facility-based care was a task-shared model of mental health care integrated within primary care. CBR was delivered by lay workers over a 12-month period, comprising of home visits (psychoeducation, adherence support, family intervention, and crisis management |
To evaluate the effectiveness of CBR plus facility-based care compared with facility-based care alone at reducing disability at 12 months in people with schizophrenia. |
Adults with a diagnosis of schizophrenia, schizoaffective disorder, or schizophreniform disorder and who had one or more markers of severe, disabling, or enduring illness. |
Ethiopia |
36 items |
Community-based rehabilitation plus facility-based care; Establishment-based service only. |
Nurses and health officers |
Schizophrenia |
| Bryant et al. (2022) 37 |
To investigate the potential impact of gPM+ on refugees’ parenting behavior and also how this may benefit their children’s mental health. |
Adult participants comprised refugees in Azraq Refugee Camp and had a child or dependent aged 10-16 years who is living in the household. |
Jordan |
12 items |
Problem Management plus (PM+); Treatment as usual |
Bachelor’s degree in Social Sciences or a Health-related discipline |
Post-traumatic stress disorder |
| Catto et al. (2022) 38 but it is unclear whether total intracorporeal surgery improves recovery compared with open radical cystectomy for bladder cancer. Objectives: To compare recovery and morbidity after robot-assisted radical cystectomy with intracorporeal reconstruction vs open radical cystectomy. Design, Setting, and Participants: Randomized clinical trial of patients with nonmetastatic bladder cancer recruited at 9 sites in the UK, from March 2017-March 2020. Follow-up was conducted at 90 days, 6 months, and 12 months, with final follow-up on September 23, 2021. Interventions: Participants were randomized to receive robot-assisted radical cystectomy with intracorporeal reconstruction (n = 169 |
To compare recovery and morbidity after robot-assisted radical cystectomy with intracorporeal reconstruction vs open radical cystectomy. |
Adult patients’ with nonmetastatic bladder cancer. |
U.K. |
No information |
Robot-assisted radical cystectomy with intracorporeal reconstruction; Open radical cystectomy. |
Physician |
Cancer |
| Cuijpers et al. (2022) 39 and their access to care has deteriorated during the Coronavirus Disease 2019 (COVID-19 |
To examine the effects of a WHO guided digital mental health intervention, Step-by-Step, supported by a non-specialist helper in Lebanon, in the context of concurring economic, humanitarian, and political crises, a large industrial disaster, and the COVID-19 pandemic. |
Syrian displaced people, above eight years of age with moderate or severe depressive symptoms and who experienced functional impairment. |
Lebanon (Syrian refugees). |
12 items |
Step-by-Step; Enhanced treatment as usual. |
Not specified |
Depression |
| Javaherirenani et al. (2022) 40 |
To evaluate the effectiveness of virtual reality exposure and response prevention in the treatment of the obsessive-compulsive disorder contamination subtype. |
Patients aged 18-50 years, with a clinical diagnosis of obsessive-compulsive disorder. |
Iran |
No information |
Cognitive Behavior Therapy and virtual reality exposure and response prevention; Cognitive Behavior Therapy. |
Psychiatrist and clinical psychologists |
Obsessive compulsive disorder |
| Richerson et al. (2023) 41 |
To assess the therapeutic and economic benefits of service dogs versus emotional support dogs for veterans with posttraumatic stress disorder. |
Veterans with post-traumatic stress disorder. |
USA |
No information |
Service dogs; Emotional support dogs. |
Not specified |
War veterans with post-traumatic stress disorder |
WHODAS como estrategia para la aplicación del modelo biopsicosocial en la práctica clínica: revisión sistemática
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