|
|
|
|
|
11 |
12 |
22 |
|
|
|
Amorin, 2008
|
Cases and controls: |
AML |
C677T |
Controls |
35 |
25 |
2 |
0.32 |
PB |
7 |
(Brazil) |
Identified as children |
|
|
Cases |
24 |
20 |
5 |
|
|
|
|
|
|
A1298C |
Controls |
40 |
16 |
4 |
0.19 |
PB |
7 |
|
|
|
|
Cases |
30 |
14 |
6 |
|
|
|
Barbosa, 2008Barbosa CG, Souza CL, Moura Neto JP, Arruda MGB, Barreto JH, Reis MG and Goncalves MS (2008) Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil. Genet Mol Biol 31:29-32.
|
Cases: Median age = 27 |
AML |
C677T |
Controls |
65 |
29 |
6 |
0.27 |
PB |
6 |
(Brazil) |
(Range: 6-70) |
|
|
Cases |
17 |
8 |
2 |
|
|
|
|
Controls: Median age = 29 |
|
A1298C |
Controls |
63 |
32 |
5 |
0.72 |
PB |
6 |
|
(Range 18-40) |
|
|
Cases |
15 |
11 |
1 |
|
|
|
|
Cases: Median age = 44 |
CML |
C677T |
Controls |
65 |
29 |
6 |
0.27 |
PB |
6 |
|
(Range: 9-93) |
|
|
Cases |
46 |
19 |
2 |
|
|
|
|
Controls: Median age = 29 (Range: 18-40) |
|
A1298C |
Controls |
63 |
32 |
5 |
0.72 |
PB |
6 |
|
|
|
|
Cases |
41 |
23 |
3 |
|
|
|
da Costa Ramos, 2006da Costa RFJ, Cartaxo MMT, Silva VC, Araújo M, Leite EP, Freitas EM, Zanrosso CW, Hatagima A, de Mello MP and Yunes JA (2006) Association between the MTHFR A1298C polymorphism and increased risk of acute myeloid leukemia in Brazilian children. Leukemia Lymphoma 47:2070-2075.
|
Cases: Average age = 7.1 ± 5.8 Controls: Average age = 5.4 ± 5.2 |
AML |
C677T |
Controls |
156 |
128 |
31 |
0.53 |
PB |
7 |
(Brazil) |
|
|
|
Cases |
93 |
67 |
22 |
|
|
|
|
|
|
A1298C |
Controls |
190 |
104 |
21 |
0.20 |
PB |
7 |
|
|
|
|
Cases |
104 |
62 |
16 |
|
|
|
Franco, 2001Franco RF, Simões BP, Tone LG, Gabellini SM, Zago MA and Falcão RP (2001) The methylenetetrahydrofolate reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukaemia. Br J Haematol 115:616-618.
|
Cases and controls: |
ALL |
C677T |
Controls |
22 |
36 |
13 |
0.80 |
HB |
8 |
(Brazil) |
Mean age = 6-7 |
|
|
Cases |
36 |
28 |
6 |
|
|
|
|
(Range: 0.2-15) |
|
A1298C |
Controls |
41 |
28 |
2 |
0.27 |
HB |
8 |
|
|
|
Cases |
36 |
30 |
5 |
|
|
|
|
Gallegos-Arreola, 2008Gallegos-Arreola M, Figuera L, Delgado J, Puebla-Pérez A and Zúñiga-González G (2008) The MTHFR polymorphism C677T in adult patients with acute lymphoblastic leukemia is associated with an increased prevalence of cytogenetic abnormalities. Blood Cells Molecules Dis 40:244-245.
|
Cases and controls: |
ALL |
C677T |
Controls |
59 |
79 |
32 |
0.54 |
PB |
6 |
Average age = 40 |
|
|
|
|
|
|
|
|
|
|
(Mexico) |
|
|
|
Cases |
64 |
78 |
28 |
|
|
|
Gutierrez-Alvarez, 2016 |
Cases: Average age = 6.9 |
ALL |
C677T |
Controls |
42 |
72 |
38 |
0.52 |
N/A |
8 |
(Range 1-15) |
|
|
|
|
|
|
|
|
|
|
(Mexico) |
Controls: Average age = 6.7 |
|
|
Cases |
22 |
36 |
12 |
|
|
|
|
|
|
A1298C |
Controls |
108 |
42 |
2 |
0.35 |
N/A |
8 |
|
|
|
|
Cases |
50 |
14 |
6 |
|
|
|
Lima, 2008Lima CS, Ortega MM, Ozelo MC, Araujo RC, De Souza CA, Lorand-Metze I, Annichino-Bizzacchi JM and Costa FF (2008) Polymorphisms of methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR), and thymidylate synthase (TYMS) in multiple myeloma risk. Leukemia Res 32:401-405.
|
Cases: Average age = 57.2 ± 11.4, Controls: Average age = 3.8 ± 2.9 |
MM |
C677T |
Controls |
92 |
79 |
17 |
0.99 |
HB |
6 |
(Brazil) |
|
|
|
Cases |
52 |
57 |
14 |
|
|
|
|
|
|
A1298C |
Controls |
127 |
49 |
12 |
0.02 |
HB |
6 |
|
|
|
|
Cases |
79 |
33 |
11 |
|
|
|
Lordelo, 2012Lordelo G, Miranda-Vilela A, Akimoto A, Alves P, Hiragi C, Nonino A, Daldegan M, Klautau-Guimarães M and Grisolia C (2012) Association between methylene tetrahydrofolate reductase and glutathione S-transferase M1 gene polymorphisms and chronic myeloid leukemia in a Brazilian population. Genet Mol Res 11:1013-1026.
|
Cases and controls: |
CML |
C677T |
Controls |
140 |
114 |
19 |
0.52 |
PB |
7 |
Identified as adults (≥20) |
|
|
|
|
|
|
|
|
|
|
(Brazil) |
|
|
|
Cases |
46 |
47 |
12 |
|
|
|
|
|
|
A1298C |
Controls |
119 |
143 |
11 |
<0.01 * |
PB |
7 |
|
|
|
|
Cases |
61 |
43 |
1 |
|
|
|
Metayer, 2011Metayer C, Scélo G, Chokkalingam AP, Barcellos LF, Aldrich MC, Chang JS, Guha N, Urayama KY, Hansen HM and Block G (2011) Genetic variants in the folate pathway and risk of childhood acute lymphoblastic leukemia. Cancer Causes Contr 22:1243.
|
Cases and controls: |
ALL |
C677T |
Controls |
59 |
91 |
27 |
0.40 |
PB |
8 |
(USA) |
Identified as children (<15) |
|
|
Cases |
62 |
72 |
20 |
|
|
|
|
|
|
A1298C |
Controls |
110 |
62 |
6 |
0.44 |
PB |
8 |
|
|
|
|
Cases |
86 |
60 |
8 |
|
|
|
Ruiz-Arguelles, 2007Ruiz-Argüelles GJ, Nancy Coconi-Linares L, Garcés-Eisele J and Reyes-Núñez V (2007) Methotrexate-induced mucositis in acute leukemia patients is not associated with the MTHFR 677T allele in Mexico. Hematology 12:387-391.
|
Cases: Median age =16 |
ALL |
C677T |
Controls |
155 |
384 |
251 |
0.71 |
PB |
4* |
(Mexico) |
(Range: 0-40) |
|
|
Cases |
2 |
10 |
16 |
|
|
|
Controls: Not provided |
|
|
|
|
|
|
|
|
|
|
Silva, 2013Silva RMS, Fontes ACL, Silva KA, Sant’Ana TA, Ramos FJC, Marques-Salles TJ, Pombo-de-Oliveira MS and Muniz MTC (2013) Polymorphisms involved in folate metabolism pathways and the risk of the development of childhood acute leukemia. Genet Test Mol Biomarkers 17:147-152.
|
Cases and controls: |
ALL |
C677T |
Controls |
95 |
108 |
21 |
0.22 |
PB |
7 |
(Brazil) |
Identified as children (<19). |
|
|
Cases |
82 |
53 |
9 |
|
|
|
|
|
|
A1298C |
Controls |
147 |
82 |
19 |
0.12 |
PB |
7 |
|
|
|
|
Cases |
55 |
53 |
28 |
|
|
|
|
|
AML |
C677T |
Controls |
95 |
108 |
21 |
0.22 |
PB |
7 |
|
|
|
|
Cases |
19 |
12 |
2 |
|
|
|
|
|
|
A1298C |
Controls |
147 |
82 |
19 |
0.12 |
PB |
7 |
|
|
|
|
Cases |
13 |
13 |
5 |
|
|
|
Zanrosso 2005Zanrosso CW, Emerenciano M, Figueiredo A, Reis M, Cordeiro SNS, Splendore A and Pombo-de-Oliveira MS (2005) Influência da metileno-tetrahidrofolato redutase na patogênese das leucemias agudas infantis. Rev Bras Cancerol 51:289-295.
|
Cases: Median age = 4 |
AML |
C677T |
Controls |
123 |
95 |
22 |
0.56 |
PB |
8 |
(Brazil) |
(Range: 0-16) |
|
|
Cases |
21 |
17 |
5 |
|
|
|
Controls: Median age = 3.5 |
|
|
|
|
|
|
|
|
|
|
|
|
|
A1298C |
Controls |
151 |
77 |
18 |
0.07 |
PB |
8 |
|
|
|
|
Cases |
28 |
13 |
1 |
|
|
|
Zanrosso 2006Zanrosso CW, Hatagima A, Emerenciano M, Ramos F, Figueiredo A, Félix TM, Segal SL, Giugliani R, Muniz MTC and Pombo-de-Oliveira MS (2006) The role of methylenetetrahydrofolate reductase in acute lymphoblastic leukemia in a Brazilian mixed population. Leukemia Res 30:477-481.
|
Cases: Average age = 6.2 |
ALL |
C677T |
Controls |
96 |
82 |
20 |
0.69 |
PB |
6 |
(Brazil) |
Controls: Average age = 25 |
|
|
Cases |
96 |
56 |
13 |
|
|
|
|
|
|
A1298C |
Controls |
111 |
76 |
12 |
0.83 |
PB |
6 |
|
|
|
|
Cases |
83 |
74 |
11 |
|
|
|