Uc.63 |
Luminal A BC LC PC GC |
worse overall survival tumor stage drug resistance overall survival advanced stage |
354 50 79 40 |
poor poor poor poor |
Marini et al., 2017Marini A, Lena AM, Panatta E, Ivan C, Han L, Liang H, Annicchiarico-Petruzzelli M, Daniele N Di, Calin GA, Candi E et al. (2017) Ultraconserved long non-coding RNA uc.63 in breast cancer. Oncotarget 8:35669-35680.
Liu et al., 2020Liu X, Zhou X, Deng CJ, Zhao Y, Shen J, Wang Y and Zhang YL (2020) Comprehensive analyses of T-UCR expression profiles and exploration of the efficacy of uc.63- and uc.280+ as biomarkers for lung cancer in Xuanwei, China. Pathol Res Pract 216:152978.
Sekino et al., 2017Sekino Y, Sakamoto N, Goto K, Honma R, Shigematsu Y, Sentani K, Oue N, Teishima J, Matsubara A and Yasui W (2017) Transcribed ultraconserved region Uc.63+ promotes resistance to docetaxel through regulation of androgen receptor signaling in prostate cancer. Oncotarget 8:94259-94270.
Sakamoto et al., 2020Sakamoto N, Sekino Y, Fukada K, Pham QT, Honma R, Taniyama D, Ukai S, Takashima T, Hattori T, Naka K et al. (2020) Uc.63+ contributes to gastric cancer progression through regulation of NF-kB signaling. Gastric Cancer 23:863-873.
|
Uc.70 |
CLL |
short time to treatment |
67 |
good |
Bomben et al., 2019Bomben R, Roisman A, D’Agaro T, Castellano G, Baumann T, Delgado J, López-Guillermo A, Zucchetto A, Dal-Bo M, Bravin V et al. (2019) Expression of the transcribed ultraconserved region 70 and the related long non-coding RNA AC092652.2-202 has prognostic value in chronic lymphocytic leukaemia. Br J Haematol 184:1045-1050.
|
Uc.84 |
BC |
less distal metastasis |
827 |
good |
Zambalde et al., 2022Zambalde EP, Adamoski D, Gradia DF, Rabinovich I, Rodrigues AC, Ivan C, Ribeiro EMSF, Calin GA and de Oliveira JC (2022) Transcribed ultraconserved regions are associated with clinicopathological features in breast cancer. Biomolecules 12:214.
|
Uc.112 |
ALL |
T-cell ALL |
62 |
poor |
das Chagas et al., 2021das Chagas PF, de Sousa GR, Kodama MH, de Biagi CAO, Yunes JA, Brandalise SR, Calin GA, Tone LG, Scrideli CA and de Oliveira JC (2021) Ultraconserved long non-coding RNA uc.112 is highly expressed in childhood T versus B-cell acute lymphoblastic leukemia. Hematol Transfus Cell Ther 43:28-34.
|
Uc.147 |
Luminal A BC |
worse overall survival |
364 |
poor |
Pereira Zambalde et al., 2021Pereira Zambalde E, Bayraktar R, Schultz Jucoski T, Ivan C, Rodrigues AC, Mathias C, Knutsen E, Silveira de Lima R, Fiori Gradia D, de Souza Fonseca Ribeiro EM et al. (2021) A novel lncRNA derived from an ultraconserved region: lnc- uc.147, a potential biomarker in luminal A breast cancer. RNA Biol 18:416-429.
|
Uc.160 |
CRC |
better overall survival |
137 |
good |
Kottorou et al., 2020Kottorou AE, Dimitrakopoulos FID, Antonacopoulou AG, Diamantopoulou G, Tsoumas D, Koutras A, Makatsoris T, Stavropoulos M, Thomopoulos KC, Hulbert A et al. (2020) Differentially methylated ultra-conserved regions Uc160 and Uc283 in adenomas and adenocarcinomas are associated with overall survival of colorectal cancer patients. Cancers (Basel) 12:895.
|
Uc.189 |
CC ES |
tumor size TNM stage distant metastasis invasion advanced clinical stage lymph node metastasis |
116 152 |
poor poor |
Wang et al., 2017Wang L, Wang XC, Li X, Gu Y, Zhou J, Jiang S, Liu J, Wu C, Ding Z, Wan Y et al. (2017) Expression of uc.189 and its clinicopathologic significance in gynecological cancers. Oncotarget 9:7453-7463.
Guo et al., 2017Guo Y, Wang C, Miao X, Chen S, Qian Y, Li G and Jiang Y (2017) Upregulation of uc.189 in patients with esophageal squamous cell carcinoma and its clinicopathologic value. Pathol Res Pract 213:1400-1403.
|
Uc.283 |
CRC |
better overall survival |
137 |
good |
Kottorou et al., 2020Kottorou AE, Dimitrakopoulos FID, Antonacopoulou AG, Diamantopoulou G, Tsoumas D, Koutras A, Makatsoris T, Stavropoulos M, Thomopoulos KC, Hulbert A et al. (2020) Differentially methylated ultra-conserved regions Uc160 and Uc283 in adenomas and adenocarcinomas are associated with overall survival of colorectal cancer patients. Cancers (Basel) 12:895.
|
Uc.338 |
CRC LC CC |
larger tumor size deeper invasion increased lymph node metastasis TNM stage, metastasis shorter overall survival and disease-free survival lymph node metastasis |
100 185 40 |
poor poor poor |
Zhang et al., 2018Zhang Y, Wang S, Qian W, Ji D, Wang Q, Zhang Z, Wang S, Ji B, Fu Z and Sun Y (2018) Uc.338 targets p21 and cyclin D1 via PI3K/AKT pathway activation to promote cell proliferation in colorectal cancer. Oncol Rep 40:1119-1128.
Tian and Feng 2018Tian Y and Feng Y (2018) Up-regulation of long noncoding RNA uc.338 predicts poor survival in non-small cell lung cancer. Cancer Biomark 22:781-785.
Li et al., 2017Li Q, Shen F and Wang C (2017) TUC338 promotes cell migration and invasion by targeting TIMP1 in cervical cancer. Oncol Lett 13:4526-4532.
|
Uc.339 |
LC |
poor survival |
30 |
poor |
Vannini et al., 2017Vannini I, Wise PM, Challagundla KB, Plousiou M, Raffini M, Bandini E, Fanini F, Paliaga G, Crawford M, Ferracin M et al. (2017) Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs. Nat Commun 8:1801.
|
Uc.388 |
CRC |
less distal metastasis |
54 |
good |
Sana et al., 2012Sana J, Hankeova S, Svoboda M, Kiss I, Vyzula R and Slaby O (2012) Expression levels of transcribed ultraconserved regions uc.73 and uc.388 are altered in colorectal cancer. Oncology 82:114-118.
|
Uc.454 |
LC |
low TNM stage and tumor size less lymph node metastasis |
98 |
good |
Zhou et al., 2018bZhou J, Wang C, Huang C, Ding Z and Shi M (2018b) TUCR.454 inhabits metastasis in lung cancer cells. Int J Clin Exp Pathol 11:1289-1296.
|