1 |
12/M |
43,XY,t(14;14)(q11;q32),-2,+3mar,-7,−13,−16, −17,−18,−19,-21,+ring(7 ?),+der(2)t(2;?)(p25;?), +der(17)t(11;17) (q13;pl2 |
TCR involvement |
CD3+, CD7+, CD8+ |
NA |
NA |
Minegishi et al.(1991)Minegishi M, Tsuchiya S, Minegishi N, Nakamura M, Abo T, Inaba T and Konno T (1991) Functional and molecular characteristics of acute lymphoblastic leukemia cells with a mature T-cell phenotype from a patient with ataxia telangiectasia. Leukemia 5:88-89.
|
2 |
Adult/M |
45,X,-Y,add(1)(q10),t(1;3)(p12;q25),+i(1)(q10), Add(7) (p22),−10,del(13)(q22q32),inv(14) (q11q32),Add(21)(p11),-22,+mar[27]/46,XY[2] |
TCR involvement |
CD2+, CD3+, CD4+, CD5+, CD25+ |
NA |
NA |
Haider et al.(2006)Haider S, Hayakawa K, Itoyama T, Sadamori N, Kurosawa N and Isobe M (2006) TCR variable gene involvement in chromosome inversion between 14q11 and 14q24 in adult T-cell leukemia. J Hum Genet 51:326-334.
|
3 |
5.6/F |
45,XX,-7,t(14;14)(q11;q32)[14]/46,XX[2] |
NA |
B lineage |
NA |
38.7 |
Raimondi et al.(2003)Raimondi SC, Zhou Y, Mathew S, Shurtleff SA, Sandlund JT, Rivera GK, Behm FG and Pui CH (2003) Reassessment of the prognostic significance of hyperdiploidy in pediatric patients with acute lymphoblastic leukemia. Cancer 98:2715-2722.
|
4 |
7/F |
46,XX,t(14;14)(q11;q32))[13]/46,XX[l] |
Breakpoints, were located telomeric, to the TCR andIGH loci |
CD10+, CD19+, CD38+ |
85 |
171 |
Shiloh & Cohen (1978)Shiloh Y and Cohen MM (1978) An improved technique of preparing bone-marrow specimens for cytogenetic analysis. In Vitro 14:510-515.
|
5 |
36/F |
46,XX,del(6)(q32),t(14;14)(q11;q32)[20] |
IGH, involvement |
CD10+, CD19+, CD22+, CD38+ |
85 |
41.1 |
Liuetal.(2004)Liu S, Bo L, Liu X, Li C, Qin S and Wang J (2004)IGH gene involvement in two cases of acute lymphoblastic leukemia with t(14;14)(q11;q32) identified by sequential R-banding and fluorescence in situ hybridization. Cancer Genet Cyto-genet 152:141-145.
|
6 |
44/M |
47,XY,t(14;14)(q11;q32),+mar[15]/46,XY[5] |
IGH, involvement |
CD9+, CD10+, CD19+, CD20+, CD22+, CD38+ |
92.5 |
73.6 |
Liuetal.(2004)Liu S, Bo L, Liu X, Li C, Qin S and Wang J (2004)IGH gene involvement in two cases of acute lymphoblastic leukemia with t(14;14)(q11;q32) identified by sequential R-banding and fluorescence in situ hybridization. Cancer Genet Cyto-genet 152:141-145.
|
7 |
45/M |
45,XY,dup(5)(q14q21),-7,t(14;14)(q11;q32)[17] |
IGH and CEBPE,involvement |
CD10+, CD19+, CD34+, CD38+ |
NA |
1 |
Akasaka et al.(2007)Akasaka T, Balasas T, Russell LJ, Sugimoto K-J, Majid A, Walewska R, Karran EL, Brown DG, Cain K, Harder L, et al. (2007) Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Blood 109:3451-3461.
|
8 |
39/F |
47,XX,+4,t(14;14)(q11;q32)[20] |
IGH and CEBPE,involvement |
CD10+,CD19+,CD79a+ |
88.5 |
3.6 |
Han et al. (2008)Han Y, Xue Y, Zhang J, Wu Y, Pan J, Wang Y, Shen J, Dai H and Bai S (2008) Translocation (14;14)(q11;q32) with simultaneous involvement of theIGH and CEBPE genes in B-lineage acute lymphoblastic leukemia. Cancer Genet Cytogenet 187:125-129.
|
9 |
5/F |
46,XX,del(9)(p21),t(9;14;14)(p12;q11;q32)[20] |
IGH and CEBPE(PAX5 and CDKN2A, deletion) involvement |
CD10+, CD19+, CD22+, CD33+, CD34+, CD38+, CD45+, CD79b+, HLA-DR+ |
90 |
3.9 |
Present case |