Abd El-Kader & Al-Shreef88 Abd El-Kader SMA, Al-Shreef FM. Impact of aerobic exercises on selected inflammatory markers and immune system response among patients with sickle cell anemia in asymptomatic steady state. Afr Health Sci. 2018;18(1):111–9. 2018 |
Measurement of the ergocycle exercise effects on inflammatory and immunological parameters. |
Randomized clinical trial. |
N: 60 volunteers. |
12 weeks of a treadmill exercise 3-days-per-week: 5 min of warm-up, 30 min of training at 60–70% of HRmax and 10 min of cool-down. |
SCAG decrease in the counts of TNF-cx, IL-6, white blood cell, neutrophils, monocytes and CD3, CD4 and CD8, compared to CGSCA. CGSCA did not change significantly during the follow-up of the study. |
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SCAG: 30 volunteers; gender is not mentioned; 26.54 ± 6.73 years old. |
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CGSCA: 30 volunteers; gender is not mentioned; 24.91 ± 7.32 years old. |
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Liem et al.99 Liem RI, Akinosun M, Muntz DS, Thompson AA. Feasibility and safety of home exercise training in children with sickle cell anemia. Pediatr Blood Cancer. 2017;64(12):e26671. 2017 |
Safety check of cyclical exercise performed at home by children and adolescents. |
Uncontrolled clinical trial. |
N:13 volunteers; Single group; 7 Women; 15 ± 2.8 years old. |
Three exercise sessions/week for 12 weeks on a stationary bicycle placed at home at 50–100% of VT, during 10−30 min were prescribed. |
Improvement of VO2max and peak power output without any adverse events correlated to the exercise. |
Hedreville et al.1010 Hedreville M, Charlot K, Waltz X, Sinnapah S, Lemonne N, Etienne-Julan M, et al. Acute moderate exercise does not further alter the autonomic nervous system activity in patients with sickle cell anemia. PLoS One. 2014;9(4):e95563. 2014 |
ANS activity check before and after moderate physical exercise. |
Cross-sectional comparison. |
N: 16 volunteers. |
Exercise test on an ergocycle with incremental load work to the 1st VT. |
No difference in ANS activity due to ET evaluated by HRV. SCAG had lower RMSSD and SDNN values than CGWSCA. |
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SCAG: 7 volunteers; 3 women; 33 ± 10.8 years old. Non-SCAG: 9 volunteers; 4 |
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Balayssac-Siransy et al.1111 Balayssac-Siransy E, Connes P, Tuo N, Danho C, Diaw M, Sanogo I, et al. Mild haemorheological changes induced by a moderate endurance exercise in patients with sickle cell anaemia. Br J Haematol. 2011;154(3):398–407. 2011 |
Rheological profile comparison among SCAG and Non-SCAG after submaximal exercise test. |
Comparative cross-section. |
women; 35 ± 8.4 years old. N: 38 volunteers. |
Symptom-limited exercise test on an ergocylce. Twenty min duration with absolute workload in exercise test. |
Some Hematological (HC, Hct, RC) and hemorheological Variables (Bv, Pv, RCSI) no changes after 20 min. (p > 0.05) |
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SCAG: 17 volunteers; no woman; 25 ± 3 years old. Non-SCAG : 21 volunteers; no woman; 22 ± 1 years old. |
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WBC is highest in SCAG (4.2 ± 1.2 compared to Non-SCAG (10.3 ± 2.2) and increases in both groups during activity, but has not been reevaluated after 20 min. 57% of the SCAG sample had PH at rest; during exercise effort this SCAG presented higher values than SCAG without HP: 51.9 ± 11.4 and 30.4 ± 4.9 respectively. |
Lima Filho et al.1212 Lima-Filho NN, Figueiredo MS, Vicari P, Canç ado R, Carvalho AC, Bordin JO, et al. Exercise-induced abnormal increase of systolic pulmonary artery pressure in adult patients with sickle cell anemia: an exercise stress echocardiography study. Echocardiography. 2016;33(12):1880–90. 2014 |
Exercise response on PSAP investigation. |
Cross-sectional comparison. |
N: 64 volunteers. |
Modified Bruce protocol, with a symptoms-limited graded treadmill exercise. |
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SCAG: 44 volunteers; 22 women; 25 ± 6.8 years old. Non-SCAG: 20 volunteers; 11 women; 28 ± 5.1 years old. |
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Waltz et al.1313 Waltz X, Hedreville M, Sinnapah S, Lamarre Y, Soter V, Lemonne N, et al. Delayed beneficial effect of acute exercise on red blood cell aggregate strength in patients with sickle cell anemia. Clin Hemorheol Microcirc. 2012;52(1):15–26. 2012 |
Endpoint test of incremental cycling exercise on hematological and hemorheological parameters. |
Cross-sectional comparison. |
N: 21 volunteers. |
Ergocycle exercise that increases in intensity until anaerobic threshold achievement. The speed exercise was kept between 60 and 70 RPM during the test. |
The values of lc, nt, lymphocytes, monocytes, reticulocytes, Hb, Htc returned to normal within 12 h after ET. Only fibrinogen value increased (2.7 ± 0.2 to 3.1 ± 0.2 g/L) and platelet count decreased (458 ± 52 to 386 ± 58 1099 Liem RI, Akinosun M, Muntz DS, Thompson AA. Feasibility and safety of home exercise training in children with sickle cell anemia. Pediatr Blood Cancer. 2017;64(12):e26671./L) for SCAG, comparing rest and 60 h after ET. |
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SCAG: 8 volunteers; 4 women; 34 ± 3.6 years old. Non-SCAG: 13 volunteers; 6 women; 35 ± 2.1 years old. |
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