Impact of ⁶⁸GA-PSMA PET / CT on treatment of patients with recurrent / metastatic high risk prostate cancer - a multicenter study

ABSTRACT

Purpose:

The purpose of our study was to evaluate the clinical impact of ⁶⁸Ga-PSMA PET / CT in the setting of biochemical recurrence of prostate cancer.

Materials and Methods:

We retrospectively evaluated 125 prostate cancer patients submitted to the ⁶⁸Ga-PSMA PET / CT due to biochemical recurrence. The parameters age, Gleason score, PSA levels, and the highest SUVmax were correlated to potential treatment changes. The highest SUVmax values were correlated with age and Gleason score. The median follow-up time was 24 months.

Results:

⁶⁸Ga-PSMA PET / CT led to a treatment change in 66 / 104 (63.4%) patients (twenty-one patients were lost to follow-up). There was a significant change of treatment plan in patients with a higher Gleason score (P = 0.0233), higher SUVmax (p = 0.0306) and higher PSA levels (P < 0.0001; median PSA = 2.55 ng / mL).

Conclusion:

⁶⁸Ga-PSMA PET / CT in prostate cancer patients with biochemical recurrence has a high impact in patient management.

Keywords:
Prostatic Neoplasms; Tomography, X-Ray Computed; Positron-Emission Tomography