Can Bipolar Vaporization be Considered an Alternative Energy Source in the Endoscopic Treatment of Urethral Strictures and Bladder Neck Contracture ?

Objective: We evaluated the outcome of bipolar energy by using PlasmaKineticTM cystoscope instruments in the treatment of urethral stricture and bladder neck contracture. Materials and Methods: treated by endoscopic bipolar vaporization. The most common etiology for stricture formation was iatrogenic (85.2%) and


INTRODUCTION
The management of urethral stricture and bladder neck contracture include periodic dilatation, blind internal urethrotomy, optical urethrotomy with or without monopolar electrocautery or various laser treatment and definitive open urethroplasty.Although long term results urethroplasty surgery can be challenging and timeconsuming.

Clinical Urology Clinical Urology
A recent survey of stricture management in the United States showed that most urologists minimally invasive means despite predictable failure.Many urologists have selected the use of endoscopic procedure as primary approach, but, currently, this ap-Although internal urethrotomy continues to be the most commonly used procedure, the optimal management is still widely debated, because the Gyrus device using PlasmaKinetic™ Endourology System (Gyrus PlasmaKinetic™ System, Medical, Maple Grove, MD).Bipolar energy enables an instant incision and vaporization of the stricture, and contrib-Thus, current prospective pilot study was conducted cystoscope instruments in the treatment of urethral strictures and bladder neck contractures.

MATERIALS AND METHODS
contractures underwent endoscopic bipolar vaporization using PlasmaKinetic™ cystoscope instruments: Plasma-Cise™ and Plasma-Cut™ (Figure -1).The study was performed in accordance with the Helsinki Declaration of the World Medical Association, and written informed institutional research consent was obtained from all patients.The strictures were localized in the urethra and the bladder neck in 22 and 5 patients, and treated with Plasma-Cise™ and Plasma-Cut™ in cause of stricture was iatrogenic (85.2%), followed patients, respectively (Table-1).Four of bladder neck contractures were detected after radical retropubic prostatectomy and one after ileal neobladder.
The stricture length was measured by both uroradiography and urethroscopy using a ureteric mm).Twenty-two patients had untreated strictures and the remaining were previously treated by cold-knife urethrotomy in three and urethroplasty in two.There  All patients were evaluated preoperatively tion, urine culture, ultrasound of the upper tract, ure-and retrograde urethrography was performed in two patients with previously placed suprapubic tube.Any active urinary tract infection was treated and routine prophylactic antibiotics were administered before surgery.All patients received general or spinal anesthesia.For safety purposes, a guidewire or 5F ureteral catheter was passed through the stricture whenever possible (Figure -2).Core-through vaporization was performed for obliterative strictures in two patients with suprapubic tube.The procedure was performed toscope instruments were easily passed through the 5F working channel of the cystoscope (Figure -1).
Vaporization was performed at 12 o'clock for desiccation was done.An 18 Fr.urethral catheter was Uroflowmetry and urethrography were performed one month after surgery and repeated urethroscopy 12 months after the procedure to as- were considered as "successful" in patients in whom symptoms and with no evidence of recurrent stricture needed any intervention after initial treatment due to had bladder neck contracture.The overall mean Q patients.
Statistical analysis was carried-out using the -

RESULTS
In 25 patients, we passed a guidewire or 5 Core-through vaporization was applied in two cases with obliterative strictures, successfully.Blood loss tained throughout the procedure.The average operawere continent after removing the catheter and able

Twenty patients without any evidence of recurrence
In 22 patients with urethral stricture, at a 2).Seventeen of these patients with urethral stricture had no signs or symptoms to suggest recurrence after We had no evidence of voiding dysfunction in these patients, and therefore we did not use urodynamic study in the evaluation.
Of the 5 cases with bladder neck contracture, a second vaporization of the contracture and the other

COMMENTS
Iatrogenic causes, which result in strictures anywhere in the urethra, are the most common cause in current clinical practice and the optimal management still remains widely debated.Though urethroplasty has a high success rate, endoscopic treatment The low success rates of cold knife urethrotomy prompted us to search for different therapeutic alternatives, and various types of lasers were attempted for this purpose.The reason for using lasers instead of cold knife depends on the basis of decreased for-YAG laser and Ho:YAG laser (1,11,12).Because of its high cost, laser treatments have not gained wide popularity for routine use.Therefore, we conducted alternative energy source for the treatment of urethral strictures and bladder neck contractures.
The intended use of bipolar vaporization using PlasmaKinetic™ cystoscope instruments is to tip design are available; braided-tip (Plasma-Cut™) or bladder neck incisions.The mechanism of the bipolar energy depends on a vapor ball that is located around the end of the device where energy is passed.sodium chloride solution that is in contact with the scar tissue from the active to the return tip of the instrument.The irrigation solution forms a thin layer to convert into vapor plasma containing energy charged particles.When these high energy charged particles come in contact with the tissue, they cause disintegration through temperatures at the treatment site, so that the depth of the thermal damage of the surrounding tissue is less than 1 mm.In recent studies, the depths of the vaporpenetration of Ho:YAG laser, which is known to be as The main difference between the bipolar tissue is not only incised but also evaporated with the vaporization.Thus, the recurrence of scar tissue can be that the tissue removal was rapid and bleeding was visually clearer than the cold knife urethrotomy.
However, the abundant corpus spongiosum around the bulbar urethra renders endoscopic treatment more successful than the bladder neck, coldknife urethrotomy is limited for short strictures in the especially when the stricture is longer or is associated bipolar vaporization can be considered an alternative treatment before performing more invasive procedure such as urethroplasty in older patients, the majority strictures and bladder neck strictures.If the bipolar also be used effectively in younger patients with short traumatic strictures in the bulbar urethra.
The success rates of cold-knife urethrotomy -netic™ technology has a slightly greater failure rate of the procedure does not affect a second repeated far more invasive procedure such as urethroplasty.repeat attempts at endoscopic correction of urethral urethroplasty.
The results of core-through urethrotomy have has been a cause of concern, especially after the use of obliterative urethral strictures is not only to incise to prevent re-stenosis.For this reason, bipolar energy the core-through procedure, lowering the risk of rescarring and re-stenosis by eliminating the need for neck contracture.As we compare success rates of bipolar energy with cold knife urethrotomy (range for the treatment of urethral strictures, our results seems to be as effective as laser treatment, and better the cost-effectiveness of the treatment, vaporization of the scarred tissue using bipolar energy by Plas-maKinetic™ cystoscopic instruments has an obvious advantage over laser therapies with good results for urethral strictures and bladder neck contractures.
There may be some limitations of this study, and the heterogeneity of the patients.

CONCLUSION
In the present study, short operative time, minimal surgical morbidity, negligible blood loss and satisfactory success rate cast new light on the endoscopic treatment of urethral stricture.Our results indicate that bipolar vaporization of urethral strictures is a safe and cost-effective procedure.
comparison with conventional resectoscope.Eur Urol. the neodymium: YAG laser for obliterative urethral plasty with actuarial evaluation of the success rates.J 18. Thomas MA, Ong AM, Pinto PA, Rha KH, Jarrett TW: Management of obliterated urinary segments using a management of anterior urethral strictures: long-term

EDITORIAL COMMENT
energy is moving forward and wider to treat urethral strictures besides transurethral resection of prostate.The endoscopic technology in the 21st century is running, not walking, towards reduction in the use of irrigation volume, bleeding, catheter, and hospital time.Urologist should not be left behind while the winds of endoscopy are blowing.A limitation of this study is the small number of patients recruited at its current status.This limitation greatly implicates the interpretation of the complication findings.The use of statistics to decide clinical relevance of these findings at this stage is premature; hence, they must be viewed cautiously.Their statistical significance or insignificance may not reflect a true clinical relevance.A double-blind randomized comparison and accrual of a larger pool of patients with a longer follow-up period will definitely provide a more accurate picture that may prove the difference between bipolar energy, cold knife urethrotomy and laser therapy.More data will be needed for the comparison of different devices and for the further assessment of complications.

EDITORIAL COMMENT
In this issue of International Braz J Urol, Basok and co-workers report their preliminary and bladder neck contracture using bipolar energy by PlasmaKinetic™ cystoscope instruments.They enrolled 22 male patients with urethral stricture and 5 with bladder neck contracture.In 22 patients with urethral stricture, postoperative mean Q Q months.Authors conclude that bipolar vaporization is results, minimal surgical morbidity and negligible be considered favorably as a new therapeutic option for the endoscopic treatment of urethral stricture and bladder neck contracture.than the old one, but it can be asserted only after a well drugs, such as antimuscarinic agents or botulinum ment before licensing, new surgical procedures have often found their way into clinical practice with little and imperfect evidence.This has also been the case several and different sets of mid-urethral sling for the treatment of stress urinary incontinence or different repair.As concerns results, it generally seems that many of the new surgical approaches have not been ogy-assessment systems.This topic was primarily addressed by the Interventional Procedures Program to the UK but are also used as a source of information for other countries (1).issue of performing randomized controlled studies on urethral reconstructive surgery (2).They realized that been poor, and typically included small numbers of taught us as regards who is dealing with new urethral reconstructive surgeries?
Most of the evidence usually comes from case series, whereas evidence from randomized trials is introduction of oral mucosa as a substitute material.Currently, oral mucosa has become the most popular substitute material in the treatment of urethral strictures, as it is readily available and easily harvested from the cheek, lip or tongue, allowing for a concealed papers that have contributed to the widespread use of the oral mucosa graft are retrospective, not prospective, nor are they randomized, controlled trials.
or new approaches to urethral strictures may represent challenges for many of us.It is a challenge for treatments to suitably selected patients, for patients who need good information when making choices and for government and private health-care funding bodies in deciding whether new procedures should be introduced into use and reimbursed.Thus, caution introducing them in clinical practice.Registers for collection of data for all patients undergoing a new procedure might represent a valuable tool regarding trials is lacking.

Figure 3 -
Figure 3 -A guide-wire was passed through the stricture whenever possible and vaporization was performed.

Table 1 -
Site and etiology of the stricture.

Table 2 -
Mean Q max of patients that did not require a subsequent procedure depending on location of the stricture.

Table 3 -
Outcome of bipolar vaporization and subsequent procedures.