| Angiotensin converting enzyme (ECA), chromosome 17; Location 17q23.3 |
rs4340: I/D (Instron insertion 16) |
Allele I: increase of PWV7373 Atwood LD, Samollow PB, Hixson JE, Stern MP, MacCluer JW. Genome-wide linkage analysis of pulse pressure in Mexican Americans. Hypertension. 2001;37(2 Pt 2):425-8.
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| Angiotensinogen (AGT), chromosome 1: location 1q42-q43 |
rs699: c.704T>C (Exon 2, p.Met235Thr) |
Allele T: reduction of carotid distensibility7474 Levy D, Larson MG, Benjamin EJ, Newton-Cheh C, Wang TJ, Hwang SJ, et al. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. BMC Med Genet. 2007;8 Suppl 1:S3.
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| Endothelial nitric oxide synthase (eNOS), chromosome 7; Location 7q36 |
rs1799983: c.894G>T (exon 7, p.Glu298Asp) |
Genotype GG: high central PP7676 Tarnoki AD, Tarnoki DL, Stazi MA, Medda E, Cotichini R, Nistico L, et al. Heritability of central blood pressure and arterial stiffness: a twin study. J Hypertens. 2012;30(8):1564-71.
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| Endothelin β receptor (ETBR), chromosome 13; Location 12q22 |
rs5351: c.831A>G (exon 5, p.Leu277Leu) |
Allele G: increase in PWV, only in women7777 Sayed-Tabatabaei FA, van Rijn MJ, Schut AF, Aulchenko YS, Croes EA, Zillikens MC, et al. Heritability of the function and structure of the arterial wall: findings of the Erasmus Rucphen Family (ERF) study. Stroke. 2005;36(11):2351-6.
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| P22phox subunit of NADPH oxidase (p22phox or CYBA), chromosome 16; Location 16p2 |
rs4673: c.242C>T(exon 3, p.Tyr72His) |
TT genotype: increased PWV, increased risk of increased arterial stiffness7979 Turner ST, Fornage M, Jack CR, Jr., Mosley TH, Kardia SL, Boerwinkle E, et al. Genomic susceptibility loci for brain atrophy in hypertensive sibships from the GENOA study. Hypertension. 2005;45(4):793-8.
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| Thioredoxin interacting protein (TXNIP), chromosome 1; Location 1p13 |
rs7212: 1035C>G3'UTR (Untranslated region) |
Allele G: increase of PWV7878 Alvim RO, Horimoto AR, Oliveira CM, Bortolotto LA, Krieger JE, Pereira AC. Heritability of arterial stiffness in a Brazilian population: Baependi Heart Study. J Hypertens. 2017;35(1):105-10.
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| Tumor necrosis factor alpha (TNF-α), chromosome 6; Location 6p21.3 |
rs1800629: -308A>G (Promoter region) |
Allele A: increased carotid stiffness index in patients with Kawasaki disease8181 Bozec E, Lacolley P, Bergaya S, Boutouyrie P, Meneton P, Herisse-Legrand M, et al. Arterial stiffness and angiotensinogen gene in hypertensive patients and mutant mice. J Hypertens. 2004;22(7):1299-307.
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| C-reactive protein (CRP), chromosome 1; Location 1q22-q25 |
rs1130864: 1444C>T 3'UTR (Untranslated region) |
T allele: increased carotid stiffness index in patients with Kawasaki disease8181 Bozec E, Lacolley P, Bergaya S, Boutouyrie P, Meneton P, Herisse-Legrand M, et al. Arterial stiffness and angiotensinogen gene in hypertensive patients and mutant mice. J Hypertens. 2004;22(7):1299-307.
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| Vascular cell adhesion molecule (VCAM-1), chromosome 1; Location 1p32-p31 |
rs3176878: c.2079T>C (exon 9, p.Asp693Asp) |
CC genotype: increase in PWV8282 Trepels T, Zeiher AM, Fichtlscherer S. The endothelium and inflammation. Endothelium. 2006;13(6):423-9.
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| Metalloproteinase 9 from the matrix (MMP-9), chromosome 20; Location 20q11.2-q13.1 |
rs17576: c.855A>G (exon 6, p.Arg279Gln) |
Allele G: increase in PWV8484 Lajemi M, Gautier S, Poirier O, Baguet JP, Mimran A, Gosse P, et al. Endothelin gene variants and aortic and cardiac structure in never-treated hypertensives. Am J Hypertens. 2001;14(8 Pt 1):755-60.
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| Elastin (ELN),Chromosome 7; Location 7q11.23 |
3'UTR - / A (untranslated region) |
Allele A: increase in PWV8383 Mitchell GF, Guo CY, Kathiresan S, Vasan RS, Larson MG, Vita JA, et al. Vascular stiffness and genetic variation at the endothelial nitric oxide synthase locus: the Framingham Heart study. Hypertension. 2007;49(6):1285-90.
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