6262. Conceição EP, Kaezer AR, Peixoto-Silva N, Felzenszwalb I, de Oliveira E, Moura EG, et al. Effects of Ilex paraguariensis (yerba mate) on the hypothalamic signaling of insulin and leptin and liver dysfunction in adult rats overfed during lactation. J Dev Orig Health Dis. 2017;8(1):123-32.
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Overnutrition: Reduction in the litter during lactation |
Wistar Rats |
Yerba mate tea (Ilex paraguariensis) |
F1: treatment by gavage with yerba mate solution (1g/kg/2mL of water) between post-natal days 150 and 180 Male |
Reversion of hypothalamic resistance to insulin Normalization of enzyme activity in the liver ↓ Lipid peroxidation ↓ Level of steatosis and of hepatic triglycerides |
6363. Nobre JL, Lisboa PC, Lima Nda S, Franco JG, Nogueira Neto JF, de Moura EG, et al. Calcium supplementation prevents obesity, hyperleptinaemia and hyperglycaemia in adult rats programmed by early weaning. Br J Nutr. 2012; 107(7):979-88., 6464. Nobre JL, Lisboa PC, Peixoto-Silva N, Quitete FT, Carvalho JC, de Moura EG, et al. Role of vitamin D in adipose tissue in obese rats programmed by early weaning and post diet calcium. Mol. Nutr. Food Res. 2016;60:810–22.
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Early weaning: physical barrier |
Wistar Rats |
Calcium carbonate |
F1: diet supplemented with calcium carbonate (10g/kg of feed) between post-natal days 120 and 180 Male |
Mitigated hyperphagia ↓ Overweight and adiposity ↓ Inflammatory state ↓ Resistance to vitamin D in adipocytes |
6565. Franco JG, Lisboa PC, da Silva Lima N, Peixoto-Silva N, Maia LA, Oliveira E, et al. Resveratrol prevents hyperleptinemia and central leptin resistance in adult rats programmed by early weaning. Horm Metab Res. 2014; 46(10):728-35.
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Early weaning: physical barrier |
Wistar Rats |
Resveratrol |
F1: treatment by gavage with resveratrol solution (30mg/kg in a 0.5% p/v solution of methylcellulose) between post-natal days 150 and 180 Male |
↓ Overweight ↓ Feed intake ↓ Hypertrophia of adipocytes ↓ Serum leptin ↓ Glycemia ↓ Resistence to leptin and insulin ↑ Adiponectine |
6666. Del Bas JM, Crescenti A, Arola-Arnal A, Oms-Oliu G, Arola L, Caimari A. Grape seed procyanidin supplementation to rats fed a high-fat diet during pregnancy and lactation increases the body fat content and modulates the inflammatory response and the adipose tissue metabolism of the male offspring in youth. Int J Obes (Lond). 2015;39(1):7-15.
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Hyperlipidic maternal diet: gestation/lactation |
Wistar Rats |
Grape seed extract rich in Procyanidin |
F0: treatment by gavage with the extract (25mg/kg): gestation/lactation F1: evaluated on post-natal day 30 Male |
↑ White adipose tissue ↑ Monocyte chemoattractant protein-1 (MCP-1) ↓ Plasmatic levels of glycerol |
6767. Resende AC, Emiliano AF, Cordeiro VS, de Bem GF, de Cavalho LC, de Oliveira PR, et al. Grape skin extract protects against programmed changes in the adult rat offspring caused by maternal high-fat diet during lactation. J Nutr Biochem. 2013; 24(12):2119-26.
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Hyperlipidic maternal diet: lactation |
Wistar Rats |
Grape skin extract (Vitis vinífera L.) |
F0: treatment by gavage with the extract (200mg/kg): lactation F1: evaluated on post-natal days 90 and 150 Male |
Reversion of resistance to insulin ↓ Systolic blood pressure ↓ Adiposity ↓ Plasmatic triglycerides ↓ Glycemia ↓ Oxidative stress |
6868. Vicente GC, Correia-Santos AM, Suzuki A, Velarde LG, Chagas MA, Boaventura GT. Maternal exposure to diets containing flaxseed flour or flaxseed oil during pregnancy and lactation protects the aortic remodeling in adult male offspring of diabetic rat dams. J Sci Food Agric. 2015;95(14):2973-80.
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Maternal diabetes induced by diet or administration of streptozocine (35mg/kg) |
Wistar Rats |
Linseed flour and oil |
F0: feed supplemented with linseed flour (25%) or linseed oil (7%): gestation/lactation F1: evaluated on post-natal day 100 Male |
Unaltered biochemical parameters Hindered aortic remodeling |
6969. Hsu CN, Hou CY, Chan JYH, Lee CT, Tain YL. Hypertension Programmed by Perinatal High-Fat Diet: Effect of Maternal Gut Microbiota-Targeted Therapy. Nutrients. 2019;11(12).pii: E2908.
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Maternal hyperlipidic diet: gestation/lactation |
Sprague Dawley |
Prebiotic: Long chain inulin or Probiotic: Lactobacillus casei
|
F0: treatment with Inulin (5% p/p) or Lactobacillus casei (2×108 UFC/day), concomitant to hyperlipidic diet F1: evaluated after 16 weeks Male |
Hindered increase in blood pressure ↑ Beneficial bacteria |
7070. Tain YL, Lee WC, Wu KLH, Leu S, Chan JYH. Resveratrol Prevents the Development of Hypertension Programmed by Maternal Plus Post-Weaning High-Fructose Consumption through Modulation of Oxidative Stress, Nutrient-Sensing Signals, and Gut Microbiota. Mol Nutr Food Res. 2018:e1800066.
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Maternal diet with high fructose content (60%): gestation/lactation |
Sprague Dawley |
Resveratrol |
F1: diet similar to maternal + resveratrol (50 mg/L) until post-natal day 90 Male |
↓ Blood pressure ↓ Renal oxidative stress Positive modulation of the intestinal microbiota |
7171. Uson-Lopez RA, Kataoka S, Mukai Y, Sato S, Kurasaki M. Melinjo (Gnetum gnemon) Seed Extract Consumption during Lactation Improved Vasodilation and Attenuated the Development of Hypertension in Female Offspring of Fructose-Fed Pregnant Rats. Birth Defects Res. 2018;110(1):27-34.
|
Supplementation of fructose in the mother's water (100 g/L): gestation |
Wistar Rats |
Melinjo seed extract (Gnetum gnemon) |
F0: diet supplemented with 0.1% Melinjo: lactation F1: evaluated in day 17 after weaning Female |
↑ Protein kinase expression activated by phosphorylated adenosine monophosphato (AMPK) and of endothelial nitric oxide synthase in the kidneys ↓ Systolic blood pressure |
7272. Matsumoto E, Kataoka S, Mukai Y, Sato M, Sato S. Green tea extract intake during lactation modified cardiac macrophage infiltration and AMP-activated protein kinase phosphorylation in weanling rats from undernourished mother during gestation and lactation. J Dev Orig Health Dis. 2017;8(2):178-87.
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Maternal hypoprotein diet: gestation |
Wistar Rats |
Green tea extract |
F0: diet supplemented with 0.12% or 0.24% of green tea extract: lactation F1: evaluated after weaning Female |
Higher dose of green tea extract: ↓ Infiltration of macrophages and areas of fibrosis in the cardiac tissue Restored the serum concentration of insulin |
7373. Mukai Y, Sun Y, Sato S. Azuki bean polyphenols intake during lactation upregulate AMPK in male rat offspring exposed to fetal malnutrition. Nutrition. 2013;29(1):291-7.
|
Maternal hypoprotein diet: gestation. |
Wistar Rats |
Adzuki beans (Vigna angularis) |
F0: received a normoprotein diet supplemented with Adzuki beans: lactation F1: evaluated at 3 and 23 weeks of age Male |
↓ Body weight ↓ Hepatic levels of triglycerides ↑ Phosphorylation of AMPK (liver and skeletal muscle) and Acetyl coenzyme Carboxylase (skeletal muscle). |