How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma

Rodrigues, Renata Miranda; Bernardo, Vagner Gonçalves; Da Silva, Sabrina Daniela; Camisasca, Danielle Resende; Faria, Paulo Antônio de Silvestre; Dias, Fernando Luiz; Pinto, Luís Felipe Ribeiro; Albano, Rodolpho Mattos; Bergmann, Anke; Lourenço, Simone de Queiroz Chaves

doi:10.1590/1678-7757-2019-0198

Renata Miranda Rodrigues

Universidade Federal Fluminense, Programa de Graduação em Odontologia, Niterói, Rio de Janeiro, Brasil.

http://orcid.org/0000-0002-3205-2345

Vagner Gonçalves Bernardo

Universidade Estadual do Rio de Janeiro (UERJ), Departamento de Bioquímica, Rio de Janeiro, Rio de Janeiro, Brasil.

http://orcid.org/0000-0003-2844-0924

Sabrina Daniela Da Silva

Segal Cancer Centre, Department of Otolaryngology, Head and Neck Surgery; Sir Mortimer B. Davis-Jewish General Hospital, Lady Davis Institute for Medical Research, Montréal, Canada.

Danielle Resende Camisasca

Universidade Federal do Espírito Santo, Departamento de Patologia Oral, Vitória, Espírito Santo, Brasil.

http://orcid.org/0000-0003-1193-2113

Paulo Antônio de Silvestre Faria

Instituto Nacional de Câncer (INCA), Divisão de Patologia, Rio de Janeiro, Rio de Janeiro, Brasil.

http://orcid.org/0000-0003-1817-4888

Fernando Luiz Dias

Instituto Nacional de Câncer (INCA), Departamento de Cirurgia de Cabeça e Pescoço, Rio de Janeiro, Rio de Janeiro, Brasil.

http://orcid.org/0000-0003-1000-7436

Luís Felipe Ribeiro Pinto

Instituto Nacional de Câncer (INCA), Centro de Pesquisas, Programa de Carcinogênese Molecular.

Rodolpho Mattos Albano

Universidade Estadual do Rio de Janeiro (UERJ), Departamento de Bioquímica, Rio de Janeiro, Rio de Janeiro, Brasil.

http://orcid.org/0000-0002-0643-901X

Anke Bergmann

Instituto Nacional de Câncer (INCA), Centro de Pesquisas, Programa de Carcinogênese Molecular.

http://orcid.org/0000-0002-1972-8777

Simone de Queiroz Chaves Lourenço Corresponding address: Simone de Queiroz Chaves Lourenço Avenida das Acácias, 150, bl.01, ap.104 - 22776-000 - Barra da Tijuca - Rio de Janeiro - RJ - Brasil. Phone: 55 21 33251648/55 21 998086400 e-mail: silourenco2015@gmail.com

Universidade Federal Fluminense, Programa de Graduação em Odontologia, Niterói, Rio de Janeiro, Brasil.

http://orcid.org/0000-0001-7970-8754

Corresponding address: Simone de Queiroz Chaves Lourenço Avenida das Acácias, 150, bl.01, ap.104 - 22776-000 - Barra da Tijuca - Rio de Janeiro - RJ - Brasil. Phone: 55 21 33251648/55 21 998086400 e-mail: silourenco2015@gmail.com

Conflict of interest disclosures

The authors declare no conflicts of interest.

Variable	Category	No. of cases	% of cases
Gender	Male	292	76.8
	Female	88	23.2
Age	<40 years	28	7.4
	≥40 <65 years	255	67.1
	≥65 years	97	25.5
Tobacco	No	56	14.7
	Current or Past	322	84.7
	Not recorded	2	0.6
Alcohol	No	73	19.2
	Current or Past	304	80.0
	Not recorded	3	0.8
Tumor site	Tongue	210	55.3
	Floor of mouth	78	20.5
	Both	92	24.2
Clinical stage	I	84	22.1
	II	160	42.1
	III	99	26.1
	IV	37	9.7
Pathological stage	I	77	20.3
	II	99	26.1
	III	82	21.6
	IV	122	32.0
pN	N0	206	54.2
	N1+2	174	45.8
Grading	Well	67	17.6
	Moderately	288	75.8
	Poorly	18	4.7
	Not recorded	7	1.9
Perineural invasion	No	293	77.1
	Yes	87	22.9
Vascular invasion	No	332	87.4
	Yes	48	12.6
Extracapsular spread	No	354	93.2
	Yes	26	6.8
Adjuvant treatment	No	176	46.3
	Yes	204	53.7
Disease progression	No	309	81.3
	Yes	71	18.7
Second primary tumor	No	321	84.5
	Yes	59	15.5

		Overall survival		Cancer-specific survival		Disease-free interval
Variable	No. of cases	(95% CI)	p value	(95% CI)	p value	(95% CI)	p value
Pathological Stage
I/II	176	(76.7 – 90.2)		(92.2 – 104.6)		(66.9 – 82.4)
III/IV	204	(46.5 – 59.4)	<0.001	(62.2 – 77.3)	<0.001	(44.2 – 59.1)	<0.001
Grading system
Well/ Moderately	355	(63.7 – 73.9)		(80.1 – 90.6)		(57.3 – 68.7)
Poorly	18	(28.3 – 61.2)	0.03	(33.8 – 70.4)	0.009	(21.9 – 71.3)	0.23
Perineural invasion
Yes	87	(40.2 – 59.2)		(54.8 – 77.5)		(33.0 – 54.3)
No	293	(67.1 – 78.2)	<0.001	(82.9 – 94.1)	<0.001	(61.9 – 74.4)	<0.001
Vascular invasion
Yes	48	(33.4 – 56.8)		(46.9 – 76.2)		(30.7 – 58.5)
No	332	(65.5 – 76.0)	<0.001	(81.2 – 92.0)	<0.001	(59.3– 71.1)	0.005
Extracapsular spread
Yes	26	(62.0 – 99.8)		(81.6 – 115.4)		(51.6 – 92.4)
No	354	(61.0 – 71.1)	0.09	(76.8 – 87.5)	0.10	(55.9 – 67.3)	0.32

Variable	Category	Overall survival		Cancer-specific survival		Disease-free interval
		HR (95% CI)	p Value	HR (95% CI)	p Value	HR (95% CI)	p Value
Pathological Stage	I+II/ III+IV	2.14 (1.60 – 2.87)	<0.001	2.72 (1.81 – 4.09)	<0.001	1.64 (1.22 – 2.21)	<0.001
Perineural invasion	Yes/ No	1.47 (1.08 – 1.99)	0.01	1.57 (1.06 – 2.31)	0.02	1.58 (1.15 – 2.16)	0.004
Grading system	Well+ Moderately/ Poorly	^a a Variable not included in the analysis	^a a Variable not included in the analysis	2.0 (1.07 – 3.73)	0.03	^a a Variable not included in the analysis	^a a Variable not included in the analysis

[1] Corresponding address: Simone de Queiroz Chaves Lourenço Avenida das Acácias, 150, bl.01, ap.104 - 22776-000 - Barra da Tijuca - Rio de Janeiro - RJ - Brasil. Phone: 55 21 33251648/55 21 998086400 e-mail: silourenco2015@gmail.com

Brasil

Brasil

How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma

Abstract

Objective:

Methodology:

Results:

Conclusion: