Nanoparticles |
Inorganic nanoparticles |
Amine-functionalized expanded pore mesoporous silica (aMSN) |
Polyacrylic acid-stabilized amorphous calcium phosphate (PAA-ACP) |
Promote re-mineralization |
Enamel white spot lesions |
In vitro
|
Hua et al, 2020 |
Silver-decorated mesoporous silica nanoparticles (Ag-MSNs) |
Chlorhexidine(CHX), Silver nanoparticles |
Antibacterial effects |
Periodontal diseases |
In vitro; In vivo
|
Lu et al, 2018 |
Mesoporous calcium silicate nanoparticles (MCSNs) |
Gentamicin; Fibroblast growth factor-2 (FGF-2) |
Antibacterial effects; Promote tissue regeneration |
- |
In vitro
|
Huang et al, 2017 |
|
Bone Morphogenetic Protein 2 (BMP-2) |
Inducing the differentiation of dental pulp cells and odontoblasts |
“Immature permanent tooth with necrotic pulp” |
In vitro
|
Huang et al, 2018 |
Poly (d,l-lactide-co-glycolide acid) (PLGA) |
Chlorhexidine |
Antibacterial effects |
- |
In vitro
|
Priyadarshini et al, 2017 |
|
Grapeseed extract (GSE) |
Reduce biodegradability of the dentin collagen matrix |
- |
In vitro
|
Fawzy etal, 2017 |
Organic nanoparticles |
|
|
Lovastatin |
Promote dentin differentiation |
Dental caries |
In vitro; In vivo
|
Lin et al, 2017 |
Liposomes |
Doxycycline |
Antibacterial activity |
Periodontal diseases |
In vitro; In vivo
|
Hu, F, et al.,2019 |
Chitosan |
Dexamethasone; Transforming growth factor-β1 (TGF-β1) |
Enhance migration, adherence and odontogenic differentiation of stem cells from apical papilla (SCAP) |
Apical periodontitis |
In vitro; In vivo
|
Shrestha et al, 2019 |
O-Carboxymethyl chitosan (OCMCH) |
Peptide histatin 5 |
Antifungal activity |
Fungal infections |
In vitro; In vivo
|
Park etal, 2017 |
Poly(amide-amine) dendrimer (PAMMA) |
Apigenin |
Antibacterial activity ; Promote remineralization |
Dental caries |
In vitro
|
Zhu et al, 2018 |
Diblock copolymers |
Famesol ; Myricetin |
Antibacterial activity |
Dental caries |
In vitro
|
Sims et al, 2020 |
Hydrogel |
|
Chitosan/β-glycerophosphate (CS/β- GP) thermosensitive hydrogels |
Bone morphogenetic protein-7 (BMP-7) ; Ornidazole (ORN) |
Promote tissue regeneration; Antibacterial activity |
Chronic periodontitis |
In vitro; In vivo
|
Zang et al, 2019 |
|
Aspirin; Erythropoietin |
Promote tissue regeneration |
Periodontitis |
In vitro; In vivo
|
Xu etal, 2019 |
|
Naringin |
Anti-inflammatory properties |
Periodontitis |
In vitro; In vivo
|
Chang et al, 2017 |
Thermosensitive micellar hydrogel |
Ibuprofen ; Basic fibroblast growth factor (bFGF) |
Anti-inflammatory activity; Promote tissue regeneration |
Peri-implantitis |
In vitro
|
Chen et al, 2019 |
Hydrogelator Nap-Phe-Phe-Tyr-OH (NapFFY) hydrogels |
Stromal cell-derived factor-1 (SDF-1) |
Promote tissue regeneration |
Periodontal bone destruction |
In vitro; In vivo
|
Tan et al, 2019 |
|
Bone morphogenetic proteins (BMPs) |
|
Alveolar bone defects |
In vitro; In vivo
|
Pan et al, 2019 |
High-stiffness transglutaminase crosslinked gelatins (TG-gels) |
IL-4 ; Stromal cell-derived factor (SDF)-1α |
Promote tissue regeneration |
Periodontitis |
In vitro; In vivo
|
He et al, 2019 |
Hyaluronic acid (HA) hydrogels |
Human dental pulp cells (hDPCs) |
Promote tissue regeneration |
— |
In vitro; In vivo
|
Silva et al, 2018 |
Peptide amphiphiles |
Ciprofloxacin (CF) and metronidazole (MN);Nitric oxide(NO) |
Promote tissue regeneration ; Antibacterial activity |
Endodontic infections |
In vitro; In vivo
|
Moon et al, 2018 |
Nanostructured lipid-biopolymer hydrogel |
Lidocaine-prilocaine (LDC-PLC) |
Anesthesia |
- |
In vitro; In vivo
|
Ribeiro et al, 2018 |
Nanofibers |
|
Polydioxanone nanofibers |
Metronidazole (MET); Ciprofloxacin (CIP); Minocycline (MINO) |
Antibacterial activity |
Periapical disease |
In vitro; In vivo
|
Bottino et al, 2019 |
|
Vasajlar endothelial growth factor (VEGF) |
Promote tissue regeneration |
Immature necrotic teeth |
In vitro; In vivo
|
Yadlapati et al, 2017 |
Cellulose nanofibers (CNF) |
Surfactin |
Antibacterial activity |
|
In vitro
|
Johnson et al, 2020 |
K-carrageenan oligosaccharides (CO) |
|
|
Periodontitis |
|
|
Gelatin films |
Econazole nitrate (ECN) |
Antifungal activity |
Stomatitis |
In vitro
|
Dolci et al, 2018 |
Chitosan; pectin; chitosan-pectin; nanostructured lipid carriers |
lidocaine-prilocaine (LDC-PLC) |
Anesthesia |
- |
In vitro
|
Ribeiro et al, 2020 |
Scaffolds |
|
Polycaprolactone (PCL); polylactic- co-glycolic acid |
Adenoviruses |
Promote tissue regeneration |
Periodontal diseases |
In vitro; In vivo
|
Pilipchuk et al, 2018 |
Chitosan; alginate; PLGA hybrid scaffolds |
Insulin-like growth factor (IGF- 1) and progression factor; Bone morphogenetic factor-6 (BMP-6) |
Promote tissue regeneration |
Periodontitis |
In vitro
|
Duruel.et al, 2017 |