Synthesis of Alkylseleno-Carbohydrates and Evaluation of their
               Antioxidant Properties

Vargas, Jaqueline P.; Pinto, Lucimar M.; Savegnago, Lucielli; Lüdtke, Diogo S.

doi:10.5935/0103-5053.20150021

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Short Reports • J. Braz. Chem. Soc. 26 (4) • Apr 2015 • https://doi.org/10.5935/0103-5053.20150021 linkcopy

Synthesis of Alkylseleno-Carbohydrates and Evaluation of their Antioxidant Properties

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Abstract

In the present study, we describe the synthesis of alkylseleno carbohydrates with different sugar scaffolds and the evaluation of their antioxidant activity profile. A compound possessing a C8 alkyl chain presented the best results in the free radical scavenging activity.

organoselenium; organochalcogens; antioxidant; selenocarbohydrates

μM	Scavenging ABTS / %	μM	Scavenging DPPH / %	μM	FRAP (absorbance)
10	2.27 ± 1.79	10	0.03 ± 0.05	10	0.19 ± 0.04
50	13.60 ± 1.57c	50	0.26 ± 0.45	50	0.22 ± 0.03
100	25.99 ± 1.61c	100	0.13 ± 0.22	100	0.26 ± 0.02
500	81.69 ± 0.90c	500	5.49 ± 3.40b	500	0.57 ± 0.08c
IC₅₀	210	-	-	-	-

μM	FRAP (absorbance)
10	0.19 ± 0.06
50	0.19 ± 0.04
100	0.20 ± 0.03
500	0.65 ± 0.07b

μM	Scavenging ABTS / %
10	3.47 ± 0.47
50	4.24 ± 3.93
100	7.64 ± 4.90
500	31.77 ± 19.26b

μM	Scavenging ABTS / %	μM	FRAP (absorbance)
10	3.04 ± 4.10	10	0.20 ± 0.04
50	12.47 ± 3.74	50	0.20 ± 0.03
100	24.90 ± 5.81c	100	0.23 ± 0.06
500	21.01 ± 7.87b	500	0.54 ± 0.07c

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Sociedade Brasileira de Química Instituto de Química - UNICAMP, Caixa Postal 6154, 13083-970 Campinas SP - Brazil, Tel./FAX.: +55 19 3521-3151 - São Paulo - SP - Brazil
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[1] ^aDenote p < 0.05;

[TFN01] ^b
p < 0.01;

[TFN02] ^c
p < 0.001 as compared to the respective control sample (one way ANOVA/Newman-Keuls). IC₅₀: concentration (μM) providing 50% inhibition in the assays. l_max: maximal inhibition (%).