1 |
CP-640186 |
--- |
--- |
--- |
5.05 |
5.93 |
NDf
|
--- |
ND |
--- |
2 |
A |
quinolin-4-yl |
--- |
--- |
7.04 |
8.01 |
ND |
--- |
ND |
--- |
3 |
A |
Anthracen-9-yl |
--- |
--- |
6.48 |
6.55 |
ND |
--- |
0.26 |
0.24 |
4 |
A |
2-phenylquinolin-4-yl |
--- |
--- |
6.07 |
7.49 |
ND |
--- |
0.68 |
0.56 |
5 |
A |
1-H-Indazole-7-yl |
--- |
--- |
5.47 |
5.92 |
ND |
--- |
0.26 |
0.28 |
6 |
A |
1-H-pyrazole-4-yl |
--- |
--- |
5.89 |
6.09 |
ND |
--- |
0.26 |
0.27 |
7 |
A |
1-H-pyrazole-3-yl |
--- |
--- |
5.52 |
6.13 |
ND |
--- |
0.24 |
0.25 |
8 |
B |
6-Me |
1-H-Indazole-7-carbonyl |
--- |
6.78 |
5.87 |
6.20 |
6.18 |
0.30 |
0.31 |
9 |
B |
6,7-Me |
1-H-Indazole-7-carbonyl |
--- |
6.20 |
5.78 |
6.40 |
6.56 |
0.32 |
0.33 |
10 |
B |
7-Me |
1-H-Indazole-7-carbonyl |
--- |
6.07 |
5.79 |
ND |
--- |
0.30 |
0.31 |
11 |
B |
6-OMe |
1-H-Indazole-7-carbonyl |
--- |
6.25 |
5.76 |
ND |
--- |
0.29 |
0.28 |
12 |
B |
6-Cl |
1-H-Indazole-7-carbonyl |
--- |
5.85 |
5.79 |
5.67 |
5.24 |
0.29 |
0.27 |
13 |
B |
6,8-Me |
1-H-Indazole-7-carbonyl |
--- |
5.88 |
5.92 |
6 |
5.51 |
0.28 |
0.26 |
14 |
B |
5-OMe |
1-H-Indazole-7-carbonyl |
--- |
5.79 |
5.81 |
6 |
6.15 |
0.27 |
0.25 |
15 |
B |
5-OMe, 6-Cl |
1-H-Indazole-7-carbonyl |
--- |
5.74 |
5.82 |
ND |
--- |
0.26 |
0.29 |
16 |
B |
7-OMe |
1-H-Indazole-7-carbonyl |
--- |
5.60 |
5.86 |
ND |
--- |
0.26 |
0.27 |
17 |
B |
7-Phenyl |
1-H-Indazole-7-carbonyl |
--- |
5.65 |
6.17 |
ND |
--- |
0.23 |
0.22 |
18 |
B |
6,7-Me |
7-Methyl-1-H-Indazole-5-carbonyl |
--- |
7.66 |
7.39 |
7.32 |
7.12 |
0.34 |
0.36 |
19 |
B |
5-OMe |
7-Methyl-1-H-Indazole-5-carbonyl |
--- |
6.98 |
6.72 |
8.19 |
7.25 |
0.32 |
0.3 |
20 |
B |
6,7-Me |
3-Methyl-1-H-Indazole-5-carbonyl |
--- |
7.44 |
6.74 |
ND |
--- |
0.34 |
0.34 |
21 |
B |
5-OMe |
3-Methyl-1-H-Indazole-5-carbonyl |
--- |
6.65 |
6.25 |
6.78 |
6.72 |
0.30 |
0.3 |
22 |
B |
6,7-Me |
7-Ethyl-1-H-Indazole-5-carbonyl |
--- |
7.75 |
7.44 |
ND |
--- |
0.34 |
0.36 |
23 |
B |
5-OMe |
7-Ethyl-1-H-Indazole-5-carbonyl |
--- |
6.99 |
6.75 |
6.82 |
6.12 |
0.31 |
0.32 |
24 |
B |
5-OMe |
3,7-Dimethyl-7-Ethyl-1-H-Indazole-5-carbonyl |
--- |
7.37 |
7.47 |
7.96 |
8.52 |
0.32 |
0.34 |
25 |
B |
5-OMe |
1-H-benzo[d]imidazole-2-carboxamide-5-carbonyl |
--- |
7.46 |
7.07 |
7.80 |
7.52 |
0.32 |
0.35 |
26 |
B |
5-OMe |
1-H-benzo[d]imidazole-2-carboxamide-5-carbonyl |
--- |
6.66 |
6.02 |
6.95 |
6.52 |
0.31 |
0.28 |
27 |
B |
5-OMe |
7-Methyl-1-H-benzo[d]imidazole-2-carboxamide-5-carbonyl |
--- |
6.76 |
6.42 |
6.90 |
7 |
0.31 |
0.34 |
28 |
B |
5-OMe |
2-Methyl-1-H-benzo[d]imidazole-2-carboxamide-5-carbonyl |
--- |
6.17 |
6.53 |
6.00 |
6.47 |
0.28 |
0.3 |
29 |
B |
5-OMe |
1-H-benzo[d][1,2,3]triazole-2-carboxamide-5-carbonyl |
--- |
5.52 |
6.04 |
6.30 |
6.56 |
0.26 |
0.24 |
30 |
B |
5-OMe |
N-Methyl-1-H-Indole-2-carboxamide-5-carbonyl |
--- |
7.36 |
7.47 |
7.96 |
8.15 |
0.30 |
0.28 |
31 |
B |
5-OMe |
N,7-Dimethyl-1H-Indole-2-carboxamide-5-carbonyl |
--- |
7.19 |
7.55 |
7.80 |
7.52 |
0.30 |
0.34 |
32 |
B |
5-OMe |
2-Phenyl-1-H-benzo[d]imidazole-5-carbonyl |
--- |
7.80 |
7.22 |
7.80 |
8.04 |
0.30 |
0.29 |
33 |
B |
5-OMe |
2-(pyridine-2-yl)-1-H-benzo[d] imidazole-5-carbonyl |
--- |
7.58 |
7.15 |
7.92 |
7.05 |
0.29 |
0.31 |
34 |
B |
5-OMe |
2-(pyridine-3-yl)-1-H-benzo[d] imidazole-5-carbonyl |
--- |
7.58 |
7.26 |
7.72 |
7.95 |
0.30 |
0.32 |
35 |
B |
5-OMe |
2-(pyridine-4-yl)-1-H-benzo[d] imidazole-5-carbonyl |
--- |
7.22 |
7.35 |
7.29 |
7.62 |
0.28 |
0.28 |
36 |
B |
5-OMe |
2-(pyridazine-4-yl)-1-H-benzo[d] imidazole-5-carbonyl |
--- |
7.00 |
7.35 |
ND |
--- |
0.27 |
0.24 |
37 |
B |
5-OMe |
2-(1-Methyl-1-H-pyrazol-3-yl)-1-H-benzo[d]imidazole-5-carbonyl |
--- |
7.72 |
7.31 |
ND |
--- |
0.30 |
0.27 |
38 |
B |
-CO2H |
7-Methyl-1-H-indazole-5-carbonyl |
--- |
6.52 |
6.76 |
ND |
--- |
0.29 |
0.27 |
39 |
B |
1-H-pyrazol-4-yl |
7-Methyl-1-H-indazole-5-carbonyl |
--- |
8.13 |
7.74 |
ND |
--- |
0.34 |
0.38 |
40 |
B |
1-Methyl-1-H-pyrazol-4-yl |
7-Methyl-1-H-indazole-5-carbonyl |
--- |
8.12 |
7.66 |
ND |
--- |
0.33 |
0.31 |
41 |
B |
1-H-pyrazol-3-yl |
7-Methyl-1-H-indazole-5-carbonyl |
--- |
7.74 |
6.88 |
8.34 |
7.94 |
0.32 |
0.3 |
42 |
B |
1-Methyl-1-H-pyrazol-3-yl |
7-Methyl-1-H-indazole-5-carbonyl |
--- |
7.50 |
7.69 |
8.21 |
8.65 |
0.30 |
0.34 |
43 |
B |
5-Methyl-1-H-pyrazol-3-yl |
7-Methyl-1-H-indazole-5-carbonyl |
--- |
7.74 |
7.69 |
8.11 |
8.32 |
0.31 |
0.32 |
44 |
B |
2-Methyloxazol-4-yl |
7-Methyl-1-H-indazole-5-carbonyl |
--- |
7.38 |
7.52 |
7.52 |
7.66 |
0.31 |
0.34 |
45 |
B |
2-Methyloxazol-5-yl |
7-Methyl-1-H-indazole-5-carbonyl |
--- |
7.72 |
7.84 |
7.40 |
7.46 |
0.31 |
0.28 |
46 |
B |
3,5-dimethylisoxazol-4-yl |
7-Methyl-1-H-indazole-5-carbonyl |
--- |
7.77 |
7.72 |
8.10 |
7.25 |
0.31 |
0.29 |
47 |
C |
1-Methyl-1-H-pyrazol-4-yl |
2-(1-Methyl-1-H-pyrazol-3-yl)-1-H-benzo[d]imidazole-5-carbonyl |
--- |
7.89 |
7.42 |
ND |
--- |
0.21 |
0.23 |
48 |
C |
1-Methyl-1-H-pyrazol-4-yl |
7-Methyl-H-indazole-5-carbonyl |
--- |
6.01 |
7.93 |
ND |
--- |
0.30 |
0.35 |
49 |
C |
-OMe |
7-Methyl-H-indazole-5-carbonyl |
--- |
7.60 |
7.74 |
ND |
--- |
0.31 |
0.34 |
50 |
D |
H |
-Me |
H |
6.74 |
6.58 |
ND |
--- |
0.33 |
0.31 |
51 |
D |
H |
-Me |
-Me |
6.81 |
6.16 |
6.44 |
6.30 |
0.31 |
0.34 |
52 |
D |
-Me |
-Me |
H |
6.60 |
6.98 |
ND |
--- |
0.30 |
0.27 |
53 |
D |
H |
H |
-Me |
6.43 |
6.62 |
6.19 |
6.20 |
0.30 |
0.32 |
54 |
D |
-NH2
|
-Me |
H |
6.11 |
6.22 |
ND |
--- |
0.28 |
0.27 |
55 |
E |
-iPr |
H |
H |
5.87 |
6.73 |
8.35 |
8.66 |
0.32 |
0.33 |
56 |
E |
-Me |
-Me |
H |
7.52 |
7.82 |
7.32 |
7.12 |
0.33 |
0.3 |
57 |
E |
-iBu |
H |
H |
7.46 |
7.64 |
7.00 |
7.12 |
0.32 |
0.3 |
58 |
E |
-Me |
H |
H |
7.64 |
6.77 |
ND |
--- |
0.32 |
0.31 |
59 |
E |
-Et |
H |
H |
7.06 |
6.95 |
ND |
--- |
0.32 |
0.34 |
60 |
E |
-iPr |
H |
-Me |
7.21 |
7.44 |
7.70 |
7.41 |
0.33 |
0.34 |