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Articles • J. Braz. Chem. Soc. 19 (5) • 2008 • https://doi.org/10.1590/S0103-50532008000500011   copy

Indium(III)-catalyzed synthesis of N-substituted pyrroles under solvent-free conditions

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A variety of N-substituted pyrroles have been synthesized by reacting γ-diketones (R¹C(O)CH2CH2C(O)R²: R¹, R² = Me, Ph) with amines (RNH2: R=Alkyl, Aryl, TsNH) or diamines (1,6-diaminohexane and 1,2-diaminoethane) in the presence of indium tribromide, indium trichloride or indium trifluoromethanesulfonate at room temperature under solvent-free conditions. The experiment protocol features simple operations, and the products are isolated in high to excellent yields (81-98%).

indium tribromide; indium trichloride; indium trifluoromethanesulfonate; pyrroles; solvent-free conditions

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