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Articles • J. Braz. Chem. Soc. 29 (7) • July 2018 • https://doi.org/10.21577/0103-5053.20170240   copy

Rapid and Efficient Uncatalyzed Knoevenagel Condensations from Binary Mixture of Ethanol and Water

Authorship SCIMAGO INSTITUTIONS RANKINGS

This paper presents a new green protocol for Knoevenagel condensations of aldehydes and compounds with an active methylene group in a binary mixture of ethanol/water (3:7, v/v). This medium favored the uncatalyzed Knoevenagel reactions and easy workup products can be obtained by precipitation in this medium and showed good isolated yields (55-100%) in short reaction times (1-60 min).

Keywords:
Knoevenagel condensation; ethanol/water; green approach; binary mixture; active methylene compounds and aldehydes

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