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Articles • J. Braz. Chem. Soc. 21 (1) • 2010 • https://doi.org/10.1590/S0103-50532010000100010 linkcopy

Open-access Synthesis and biological activity of novel statine derivatives containing ferrocenyl moiety

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    Abstracts

    In a search for new aspartic protease inhibitors, conjugates of ferrocene with statine were designed and synthesized by coupling reaction using the standard N,N'-dicyclohexylcarbodiimide (DCC) and 1-hydroxybenzotriazole (HOBt) protocol. The title compounds were characterized by IR, ¹H NMR spectroscopy, MS and elemental analysis. The results of bioassay showed that some title compounds could serve as a starting point.

    statine; ferrocene; aspartic protease; synthesis; biological activity

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