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Articles • J. Braz. Chem. Soc. 27 (8) • Aug 2016 • https://doi.org/10.5935/0103-5053.20160140 linkcopy

Open-access Annularins I and J: New Metabolites Isolated from Endophytic Fungus Exserohilum rostratum

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    Abstract

    The paper describes the isolation of ergosterol peroxide, monocerin, annularin I and annularin J compounds of Exserohilum rostratum biomass extracts. Compounds were isolated by silica gel column chromatography in polarity gradient and the structures were determined by nuclear magnetic resonance (NMR) and mass spectrometry (MS) methods. Monocerin, annularin I and annularin J compounds were tested against Escherichia coli, Pseudomonas aeruginosa and Bacillus subtilis bacteria and showed moderate activity. Annularin I and annularin J compounds are new natural products.

    Keywords:
    annularins; polyketides; E. rostratum; endophytic fungi

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