Recent Progress in the Use of Pd-Catalyzed C-C Cross-Coupling Reactions in the Synthesis of Pharmaceutical Compounds

Autoria SCIMAGO INSTITUTIONS RANKINGS

A grande capacidade do paládio de formar ligações carbono-carbono entre substratos apropriadamente funcionalizados permitiu que os químicos orgânicos efetuassem transformações antes impossíveis ou alcançáveis somente através de rotas muito longas. Neste contexto, uma das mais elegantes e importantes aplicações das reações de acoplamento cruzado catalisadas por paládio é a síntese de compostos de interesse farmacêutico. A presente revisão tem por objetivo apresentar uma visão geral do uso de acoplamentos cruzados na síntese de componentes de medicamentos (ou de candidatos a medicamentos), independentemente da escala, compreendendo o período de 2011 até o final de julho de 2014.

Autoria

person André F. P. Biajoli

schoolLaboratory of Molecular Catalysis, Institute of Chemistry, UFRGS, Av. Bento Gonçalves, 9500, 91501-970 Porto Alegre-RS, BrazilInstitute of ChemistryBrazilPorto Alegre, RS, BrazilLaboratory of Molecular Catalysis, Institute of Chemistry, UFRGS, Av. Bento Gonçalves, 9500, 91501-970 Porto Alegre-RS, Brazil

person Cristiane S. Schwalm

person Jones Limberger

person Thiago S. Claudino

person Adriano L. Monteiro *

person* e-mail:
adriano.monteiro@ufrgs.br

Adriano L. Monteiro obtained his PhD degree from the Université Paul Sabatier (Toulouse, France) in 1993 working with PhD Igor Tkatchenko, and was a postdoctoral fellow in 1998 at Massachusetts Institute of Technology (Cambridge, USA) working with Prof Stephen L. Buchwald. He joined the Department of Organic Chemistry of UFRGS (Porto Alegre, Brazil) in 1994 as assistant professor and is currently associate professor of Organic Chemistry. His research focuses on homogeneous catalysis with emphasis on metal-mediated synthetic methodologies for the construction of C-C bonds.

Cristiane S. Schwalm obtained her PhD degreein 2014from Universidade Estadual de Campinas (Campinas, Brazil) under advice of Prof Carlos Roque Duarte Correia. She is currently a postdoctoral fellow in Laboratory of Molecular Catalysis at Universidade Federal do Rio Grande do Sul (Porto Alegre, Brazil), where she works on the synthesis of novel ligands for ethylene oligomerization under the supervision of Prof Adriano Lisboa Monteiro.

Thiago S. Claudino graduated in Pharmacy (2003) and Master in Pharmaceutical Sciences (2009) from Universidade Federal do Rio Grande do Sul. Currently, he is a PhD student in Chemistry at the Universidade Federal do Rio Grande do Sul under guidance of Prof Adriano Lisboa Monteiro. He has experience onthefollowing subjects: organic synthesis, catalysis and medicinal chemistry.

André F. P. Biajoli studied at Universidade Estadual de Campinas (Campinas, Brazil), obtaining a PhD in organic chemistry under the guidance of Prof Carlos Roque D. Correia. He is currently a postdoctoral fellow in the Laboratory of Molecular Catalysis (LAMOCA) at Universidade Federal do Rio Grande do Sul (Porto Alegre, Brazil) with Prof Adriano L. Monteiro as supervisor, with his research focusing mainly on cross-coupling reactions.

Jones Limberger obtained his PhD degree from Universidade Federal do Rio Grande do Sul (Porto Alegre, Brazil) in 2012 under advice of Prof Adriano Lisboa Monteiro. He has currently a postdoctoral fellow in Laboratory of Molecular Catalysis (Porto Alegre, Brazil), under supervision of Prof Jairton Dupont. His current research interests focus on development of novel metal-catalyzed methodologies for the obtainment of fine chemical products.

SCIMAGO INSTITUTIONS RANKINGS

Laboratory of Molecular Catalysis, Institute of Chemistry, UFRGS, Av. Bento Gonçalves, 9500, 91501-970 Porto Alegre-RS, BrazilInstitute of ChemistryBrazilPorto Alegre, RS, BrazilLaboratory of Molecular Catalysis, Institute of Chemistry, UFRGS, Av. Bento Gonçalves, 9500, 91501-970 Porto Alegre-RS, Brazil

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