Recent Progress in the Use of Pd-Catalyzed C-C Cross-Coupling Reactions in the Synthesis of Pharmaceutical Compounds

The impressive ability of palladium to assemble C-C bonds between appropriately functionalized substrates has allowed synthetic organic chemists to perform transformations that were previously impossible or only possible using multi-step approaches. In this context, one of the most important and elegant applications of the Pd-catalyzed C-C coupling reactions currently is the synthesis of pharmaceuticals. This review is intended to give a picture of the applications of Pd-catalyzed C-C cross-coupling reactions for the synthesis of drug components or drug candidates regardless of the scale from 2011 through to the end of July, 2014.

cross-coupling reactions; Heck reactions; palladium; pharmaceuticals

Authorship

André F. P. Biajoli

Laboratory of Molecular Catalysis, Institute of Chemistry, UFRGS, Av. Bento Gonçalves, 9500, 91501-970 Porto Alegre-RS, BrazilInstitute of ChemistryBrazilPorto Alegre, RS, BrazilLaboratory of Molecular Catalysis, Institute of Chemistry, UFRGS, Av. Bento Gonçalves, 9500, 91501-970 Porto Alegre-RS, Brazil

Cristiane S. Schwalm

Jones Limberger

Thiago S. Claudino

Adriano L. Monteiro ^** e-mail: adriano.monteiro@ufrgs.br

* e-mail: adriano.monteiro@ufrgs.br

Adriano L. Monteiro obtained his PhD degree from the Université Paul Sabatier (Toulouse, France) in 1993 working with PhD Igor Tkatchenko, and was a postdoctoral fellow in 1998 at Massachusetts Institute of Technology (Cambridge, USA) working with Prof Stephen L. Buchwald. He joined the Department of Organic Chemistry of UFRGS (Porto Alegre, Brazil) in 1994 as assistant professor and is currently associate professor of Organic Chemistry. His research focuses on homogeneous catalysis with emphasis on metal-mediated synthetic methodologies for the construction of C-C bonds.

Cristiane S. Schwalm obtained her PhD degreein 2014from Universidade Estadual de Campinas (Campinas, Brazil) under advice of Prof Carlos Roque Duarte Correia. She is currently a postdoctoral fellow in Laboratory of Molecular Catalysis at Universidade Federal do Rio Grande do Sul (Porto Alegre, Brazil), where she works on the synthesis of novel ligands for ethylene oligomerization under the supervision of Prof Adriano Lisboa Monteiro.

Thiago S. Claudino graduated in Pharmacy (2003) and Master in Pharmaceutical Sciences (2009) from Universidade Federal do Rio Grande do Sul. Currently, he is a PhD student in Chemistry at the Universidade Federal do Rio Grande do Sul under guidance of Prof Adriano Lisboa Monteiro. He has experience onthefollowing subjects: organic synthesis, catalysis and medicinal chemistry.

André F. P. Biajoli studied at Universidade Estadual de Campinas (Campinas, Brazil), obtaining a PhD in organic chemistry under the guidance of Prof Carlos Roque D. Correia. He is currently a postdoctoral fellow in the Laboratory of Molecular Catalysis (LAMOCA) at Universidade Federal do Rio Grande do Sul (Porto Alegre, Brazil) with Prof Adriano L. Monteiro as supervisor, with his research focusing mainly on cross-coupling reactions.

Jones Limberger obtained his PhD degree from Universidade Federal do Rio Grande do Sul (Porto Alegre, Brazil) in 2012 under advice of Prof Adriano Lisboa Monteiro. He has currently a postdoctoral fellow in Laboratory of Molecular Catalysis (Porto Alegre, Brazil), under supervision of Prof Jairton Dupont. His current research interests focus on development of novel metal-catalyzed methodologies for the obtainment of fine chemical products.

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