| Kandzari DE, Böhm M, Mahfoud F, et al, on behalf of the SPYRAL HTN-ON MED Trial Investigators |
Renal Denervation |
Humans/n=80 |
This trial has shown significant differences in favor of renal denervation reported between the groups 3 months after the procedure evaluated by 24-h ambulatory measurements. (In favor)
|
| Azizi M, Schmieder, RE, Mahfoud F, et al, on behalf of the RADIANCE-HTN Investigators |
Endovascular ultrasound renal denervation |
Humans/n=146 |
The study concluded that the procedure was able to significantly reduce systolic and diastolic blood pressure between the groups at 2 months after the procedure evaluated by 24-h ambulatory measurements. (In favor)
|
| Townsend RR, Mahfoud F, Kandzari DE, et al. On behalf of the SPYRAL HTN-OFF MED trial investigators (2017) |
Renal Denervation |
Humans/n=80 |
This trial has shown significant differences in favor of renal denervation reported between the groups in the 3 months change in 24-h ambulatory measurements. (In favor)
|
| Bhatt DL, M.D, MPH, et al. For the SYMPLICITY HTN-3 Investigators (2014) |
Renal artery denervation |
Humans/n=535 |
This trial did not demonstrate a benefit of renal artery denervation on reduction in ambulatory BP in either the 24-h or day and night periods compared with sham. (Against)
|
| Fink GD, Phelps JT. (2017) |
Bilateral renal denervation |
Rats/n=15 |
Data from this animal experiment did not identify a clinically useful way of predicting the magnitude of the blood pressure fall that occurs after renal denervation. (Against)
|
| Salman IM, Hildreth CM, Phillips JK. (2017) |
Vagal afferent stimulation |
Rats/n=63 |
Data from this study provides direct insight into the role of the vagal afferent outflow in the regulation of cardiovascular function in chronic kidney disease in males and females (In favor)
|
| Goodwill VS, Terrill C, Hopewood I, Loewy AD, Knuepfer MM (2017) |
Infusion of isotonic or hypertonic NaCl |
Rats/n=56 |
This experiment has shown that normal saline had little effect on afferent nerve activity, while hypertonic NaCl elicited an increase in renal afferent nerve activity. (In favor)
|
| Zheng H, Patel KP (2017) |
- |
- |
This study shows that an enhanced/altered afferent renal input to the paraventricular nucleus in disease conditions such as chronic heart failure and hypertension may be involved in producing elevated sympathetic nerve activity commonly observed in these disease states. (In favor)
|
| Howden EJ, Esler JSLM, Levine BD (2017) |
Endurance training |
- |
According to this review, endurance exercise training clearly lowers sympathetic activity in sympatho-excitatory disease states. It also influences many factors which may mediate a reduction in sympathetic activity However, the utility of endurance training as a countermeasure to alter sympathetic nerve activity in CKD patients remains to be determined (Inconclusive)
|
| Olaf Grisk (2017) |
Bilateral renal denervation |
- |
According to this review, even if new techniques were applied that may reduce the degree of renal reinnervation, the beneficial actions of renal denervation may still be offset by denervation supersensitivity. (Against)
|
| Nishihara M, Takesue K, Hirooka Y (2017) |
Bilateral renal denervation and bicuculline microinjection |
Mice/n=101 |
According to this study, renal denervation has a sustained antihypertensive effect by increasing the urinary sodium excretion levels in the early phase and inhibiting SNA in association with augmented (In favor) GABA-ergic input into the paraventricular nucleus of the hypothalamus in the late phase in hypertensive mice with chronic kidney disease. (In favor)
|
| Yao Y, Davis G, Harrison JC, Walker RJ, Sammut IA (2017) |
Diabetes induction and bilateral renal denervation |
Rats/n=27 |
Findings of this study support the conclusions that sympathetic tone is important in the pathophysiological development of hypertensive renal damage in diabetes. (In favor)
|
| Veiga GL, Nishi EE, Estrela HF, Lincevicius GF, Gomes GN, Sato AYS, Campos RR, Bergamaschi CT (2017) |
Induction of chronic kidney disease and total renal denervation |
Rats/n=44 |
Data from this study suggest that hypertension, reduced renal function, and increased sympathoexcitation to other targets are at least partially driven by renal nerves in CKD. (In favor)
|
Renal sympathetic denervation for resistant hypertension: where do we stand after more than a decade