Alves, Caroline S.; Santana, Lucas A. M.; Felix, Fernanda A.; Ayres, Lucas G. C.; Silva, Erika R.; Takeshita, Wilton M.

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Jornal Brasileiro de Patologia e Medicina Laboratorial

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CASE REPORT • J. Bras. Patol. Med. Lab. 57 • 2021 • https://doi.org/10.5935/1676-2444.20210041 copiar

Atypical oral features of patient with neurofibromatosis type 1: case report

Autoría SCIMAGO INSTITUTIONS RANKINGS

RESUMEN

El propósito de este artículo es ayudar a los dentistas clínicos a identificar la neurofibromatosis tipo 1 y sus variantes. Presentamos un caso raro de un hombre de 68 años, afectado desde la infancia por la presencia de nódulos generalizados en todo el cuerpo, provocando deformaciones estéticas. Curiosamente, el impacto en la cavidad oral no fue significativo, con nódulos solo en la encía, un área de manifestación raro. La radiografía panorámica mostró un ligero agrandamiento del canal mandibular. Tras un año de seguimiento, el paciente falleció por complicaciones cardiovasculares provocadas por el síndrome.

Palabras clave
anomalias de la boca; neurofibroma; tejido nervioso

Authors	Type of study	Oral clinical manifestations	Oral radiographic findings
Sarmento et al. (2017)(¹⁴14 Sarmento DJS, de Carvalho SHG, de Araújo Filho JCWP, Carvalho MV, da Silveira EJD. Florid cemento-osseous dysplasia and peripheral giant cell granuloma in a patient with neurofibromatosis 1. An Bras Dermatol. 2017; 92(2): 249–52.)	Clinical case	Giant cell lesion and florid cemento-osseous dysplasia	Not reported
Friedrich et al. (2017)(²¹21 Friedrich RE, Lehmann JM, Rother J, et al. A lateral cephalometry study of patients with neurofibromatosis type 1. J Craniomaxillofac Surg. 2017; 45(6): 809–20.)	Research	Not applicable	Asymmetry in the facial skeleton, no changes in the sella turcica
Mahmud et al. (2016)(¹⁵15 Mahmud SA, Shah N, Chattaraj M, Gayen S. Solitary encapsulated neurofibroma not associated with neurofibromatosis-1 affecting tongue in a 73-year-old female. Case Rep Dent. 2016; 2016.)	Clinical case	Neurofibroma in tongue	Not reported
Shekar et al. (2015)(⁹9 Shekar V, Rangdhol V, Baliah WJ, Thirunavukarasu S. An unusual oral manifestation of type 1 neurofibromatosis: a case report and review of literature. J Nat Sci Biol Med. 2015; 6(1): 261.)	Clinical case	Neurofibroma gingival	Not reported
Cunha et al. (2015)(¹⁸18 Cunha KS, Rozza-De-Menezes RE, Luna EB, et al. High prevalence of hyposalivation in individuals with neurofibromatosis 1: a case-control study. Orphanet J Rare Dis. 2015; 10(1).)	Research	High prevalence of hyposalivation	Not reported
Visnapuu et al. (2012)(¹⁹19 Visnapuu V, Peltonen S, Tammisalo T, Peltonen J, Happonen RP. Radiographic findings in the jaws of patients with neurofibromatosis 1. J Oral Maxillofac Surg. 2012; 70(6): 1351–7.)	Research	Not applicable	Increased diameter of the mandibular canal
Kobayashi et al. (2012)(²²22 Kobayashi R, Matsune K, Ohashi H. Fused teeth, macrodontia and increased caries are characteristic features of neurofibromatosis type 1 patients with NF1 gene microdeletion. J Pediatr Genet. 2012; 1(1): 25–31.)	Research	Not applicable	Macrodontia and excess of dental caries

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[1] CORRESPONDING AUTHOR: Lucas Alves da Mota Santana. e-mail: lucassantana.pat@gmail.com