ABSTRACT
Follicular dendritic cell sarcoma is a rare neoplasm, first described in 1986 by Monda. Case 1: A female patient, 50-year-old performed abdominal computed tomography scan that detected a tumor lesion of 8.0 cm in the mesentery. She underwent resection of the lesion. Microscopic examination revealed epithelioid neoplasm, interspersed with lymphocytes, and positive immunohistochemical staining for CD21 and CD35. The patient underwent adjuvant chemotherapy. Case 2: A male patient, 21-year-old presented right-sided neck mass measuring 7.0 cm. The biopsy revealed proliferation of spindle cells, interspersed with inflammatory infiltrate and storiform arrangement, and positive immunohistochemical staining for CD21 and CD23. The patient underwent neoadjuvant radiotherapy and surgical resection.
Key words:
follicular dendritic cell; dendritic cell neoplasm; follicular dendritic cell sarcoma; pathology
A) post contrast axial CT image shows a well defined mass near the transverse colon measuring approximately 8.0 cm; B) post contrast sagittal CT scan with mild to moderate heterogeneous enhancement. CT: computed tomography.
Sheets of epithelioid cells with eosinophilic cytoplasm. FDCS: follicular dendritic cell sarcoma.
High magnification shows that the neoplastic cells are epithelioid with ovoid to elongated bland nuclei, distinct nucleolus and eosinophilic cytoplasm. There are numerous small lymphocytes interspersed between tumor cells. FDCS: follicular dendritic cell sarcoma.
A) the tumor has numerous mitoses, some atypical; B) areas of necrosis; C) and D) immunohistochemical staining shows that this neoplasm is positive for CD21 (C) and for fascin (D). FDCS: follicular dendritic cell sarcoma; CD21:
Immunohistochemical staining show that this neoplasm is focal positive for CD45 (A), D2- 40 (B), CD68 (C), and S100 (D). FDCS: follicular dendritic cell sarcoma; CD45: ; D2-40: ; CD68: ; S100: .
Post contrast CT images show a well-defined cervical mass stage II and III on the right side extending to the soft palate measuring approximately 6.0 cm, with moderate heterogeneous enhancement. A) and B) axial CT image; C) sagittal CT image; D) coronal CT image. CT: computed tomography.
Whorling bundles and fascicles of tumor cells are admixed with adjacent lymphoid infiltrates. FDCS: follicular dendritic cell sarcoma.
Spindle tumor cells are admixed with numerous lymphocytes. FDCS: follicular dendritic cell sarcoma.
Immunohistochemical staining shows that this neoplasm is positive for CD21 (A) and CD23 (B). FDCS: follicular dendritic cell sarcoma; CD21: ; CD23: .