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LABORATORY MEDICINE, Breifing communication • J. Bras. Patol. Med. Lab. 53 (2) • Mar-Apr 2017 • https://doi.org/10.5935/1676-2444.20170020 linkcopy

Open-access CD64 expression on polymorphonuclear cells as a potential marker for monitoring the human cytomegalovirus replication after kidney transplantation

Expressão de CD64 em polimorfonucleares como potencial marcador para o monitoramento da replicação do citomegalovírus humano após transplante renal

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    ABSTRACT

    Human cytomegalovirus (HCMV) infection is the main cause of morbidity in kidney transplant recipients. This study aims to investigate if CD64 expression on polymorphonuclear (PMN) cells is useful for the detection of HCMV infection in eleven kidney recipients during sixty days. From the total patients, nine were positive for both pp65 antigenemia and HCMV by quantitative polymerase chain reaction (qPCR), all of which had circulating neutrophils expressing CD64 3-4 weeks prior to pp65 antigenemia peak. These results suggest that quantification of PMN CD64 together with pp65 antigenemia could be useful for the early diagnosis of HCMV after transplantation.

    Key words:
    cytomegalovirus; IgG receptors; kidney transplantat; neutrophils

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