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Emergence of polymyxin B-resistant Acinetobacter baumannii in hospitals in Rio de Janeiro

Emergência de Acinetobacter baumannii resistente a polimixina B em hospitais do Rio de Janeiro



Acinetobacter baumannii has been considered a prevalent pathogen in hospitals, raising concern in the medical community due to its broad spectrum of antimicrobial resistance. Since it is a subject that arouses much interest, it has been increasingly studied. Due to the emergence of multidrug-resistant (MDR) Gram-negative bacteria, the use of polymyxins was reestablished. The polymyxins have been considered the only option for the treatment of severe infections caused by MDR A. baumannii.


To investigate the susceptibility profile of A. baumannii to polymyxin B.

Material and method:

92 clinical isolates from two public hospitals in the Rio de Janeiro city were studied using broth microdilution method.


Most of the isolates were resistant to polymyxin B, 81.5% (n = 75), and minimum inhibitory concentration (MIC) values ranged between 4-64 mcg/ml.


These results are a concern since currently the polymyxins have been considered the most effective therapeutic option against MDR isolates of A. baumannii.

Key words:
multidrug-resistance; Acinetobacter baumannii; polymyxin B; hospital infection.

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