COVID-19 pneumonia and the reversed halo sign

Lucas de Pádua Gomes de Farias Daniel Giunchetti Strabelli Márcio Valente Yamada Sawamura About the authors

A 56-year-old male patient with chronic bronchitis reported worsening of his usual dyspnea for one week prior to hospital admission, evolving to fever, productive cough, and non-massive hemoptysis, as well as a progressive need for oxygen supplementation, in the last 24 h.

Multidetector CT scans of the chest showed diffuse, extensive ground-glass opacities, together with foci of consolidation, many of them representing reversed halo signs, in both lungs. Screening for multiple respiratory pathogens was positive for SARS-CoV-2, indicating that the patient had COVID-19.

The reversed halo sign, defined as an area with ground-glass attenuation surrounded by partial or complete rings of consolidation, is a radiological finding present in patients with pneumonia caused by the new coronavirus. The reversed halo sign has been reported in other forms of viral pneumonia.11. Marchiori E, Zanetti G, Escuissato DL, Souza AS Jr, Meirelles GSP, Fagundes J, et al. Reversed halo sign: high-resolution CT scan findings in 79 patients. Chest. 2012;141(5):1260-1266. https://doi.org/10.1378/chest.11-1050
https://doi.org/10.1378/chest.11-1050...
,22. Bernheim A, Mei X, Huang M, Yang Y, Fayad ZA, Zhang N, et al. Chest CT Findings in Coronavirus Disease-19 (COVID-19): Relationship to Duration of Infection [published online ahead of print, 2020 Feb 20]. Radiology. 2020;200463. https://doi.org/10.1148/radiol.2020200463
https://doi.org/10.1148/radiol.202020046...
When identified, the reversed halo sign typically occurs longer after symptom onset, suggesting that this CT finding correlates with the underlying pathophysiology of the disease process as it organizes.22. Bernheim A, Mei X, Huang M, Yang Y, Fayad ZA, Zhang N, et al. Chest CT Findings in Coronavirus Disease-19 (COVID-19): Relationship to Duration of Infection [published online ahead of print, 2020 Feb 20]. Radiology. 2020;200463. https://doi.org/10.1148/radiol.2020200463
https://doi.org/10.1148/radiol.202020046...
Such findings indicate that organizing pneumonia is one of the mechanisms of lung injury.33. Wu Y, Xie YL, Wang X. Longitudinal CT Findings in COVID-19 Pneumonia: Case Presenting Organizing Pneumonia Pattern. Radiol Cardiothorac Imaging. 2020;2(1):e200031. https://doi.org/10.1148/ryct.2020200031
https://doi.org/10.1148/ryct.2020200031...

Figure 1
Images in coronal (A), sagittal (B), and axial (C and D) reconstructions from multidetector CT, showing multiple diffuse ground glass areas in both lungs, surrounded by partial or complete rings of consolidation, known as the reversed halo sign (arrows), in a 56-year-old male patient with COVID-19 pneumonia.

REFERENCES

  • 1
    Marchiori E, Zanetti G, Escuissato DL, Souza AS Jr, Meirelles GSP, Fagundes J, et al. Reversed halo sign: high-resolution CT scan findings in 79 patients. Chest. 2012;141(5):1260-1266. https://doi.org/10.1378/chest.11-1050
    » https://doi.org/10.1378/chest.11-1050
  • 2
    Bernheim A, Mei X, Huang M, Yang Y, Fayad ZA, Zhang N, et al. Chest CT Findings in Coronavirus Disease-19 (COVID-19): Relationship to Duration of Infection [published online ahead of print, 2020 Feb 20]. Radiology. 2020;200463. https://doi.org/10.1148/radiol.2020200463
    » https://doi.org/10.1148/radiol.2020200463
  • 3
    Wu Y, Xie YL, Wang X. Longitudinal CT Findings in COVID-19 Pneumonia: Case Presenting Organizing Pneumonia Pattern. Radiol Cardiothorac Imaging. 2020;2(1):e200031. https://doi.org/10.1148/ryct.2020200031
    » https://doi.org/10.1148/ryct.2020200031

Publication Dates

  • Publication in this collection
    22 Apr 2020
  • Date of issue
    2020
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