Investigação da cognição na esquizofrenia: propriedades psicométricas de instrumentos para avaliação de atualização da memória de trabalho

Berberian, Arthur A.; Gadelha, Ary; Dias, Natália M.; Mecca, Tatiana P.; Bressan, Rodrigo A.; Lacerda, Acioly T.

doi:10.1590/0047-2085000000084

Arthur A. Berberian

Universidade Federal de Sao Paulo (Unifesp), Department of Psychiatry, Interdisciplinary Lab of Clinical Neurosciences (LiNC), and Schizophrenia Program (PROESQ).

Centro Universitário FIEO, Educational Psychology Post-Graduate Program.

Ary Gadelha

Universidade Federal de Sao Paulo (Unifesp), Department of Psychiatry, Interdisciplinary Lab of Clinical Neurosciences (LiNC), and Schizophrenia Program (PROESQ).

Natália M. Dias

Centro Universitário FIEO, Educational Psychology Post-Graduate Program.

Universidade Presbiteriana Mackenzie, Developmental Disorders Post-Graduation Program.

Tatiana P. Mecca

Centro Universitário FIEO, Educational Psychology Post-Graduate Program.

Universidade Presbiteriana Mackenzie, Developmental Disorders Post-Graduation Program.

Rodrigo A. Bressan

Universidade Federal de Sao Paulo (Unifesp), Department of Psychiatry, Interdisciplinary Lab of Clinical Neurosciences (LiNC), and Schizophrenia Program (PROESQ).

Acioly T. Lacerda

Universidade Federal de Sao Paulo (Unifesp), Department of Psychiatry, Interdisciplinary Lab of Clinical Neurosciences (LiNC), and Schizophrenia Program (PROESQ).

Address for correspondence: Arthur A. Berberian. Laboratório Interdisciplinar de Neurociências Clínicas. Edifício de Pesquisas II. Rua Pedro de Toledo, 669, 3° andar, fundos, Vila Clementino. 04039-032 – São Paulo, SP, Brazil. Phone: (+55 11) 5576-4845. E-mail: a.berberian@unifesp.br

INDIVIDUAL CONTRIBUTIONS

Arthur A. Berberian – Designed the study and was responsible for data collection and data management.

Acioly T. Lacerda – Were also responsible for critical revision of intellectual content and approved the final version to be published.

All authors contributed significantly in the conception of the study, analysis and interpretation of data; also participated in the conceptualization of the manuscript, development of its content, and the writing of the manuscript.

CONFLICTS OF INTEREST

No conflicts of interest between authors.

Domain	Variable	Schizophrenia patients (N = 141)		Healthy control (N = 119)		Test value	P-values
		Mean	SD	Mean	SD
Age (years)		36.14	9.87	34.03	10.43	F = 2.00	0.11
Education (years)		10.65	3.21	11.23	2.74	F = 2.20	0.13
Mother's Educ.		7.10	5.65	6.13	4.18	F = 2.20	0.19
Non-verbal intelligence		27.43	23.26	38.91	23.18	F = 17.82	< 0.001
Duration of illness		6.08	5.05
Age of onset		22.90	7.07
PANSS	Positive symptoms	13.16	4.71
	Negative symptoms	17.58	5.92
	General	30.13	7.30
	Total score	60.12	15.88
GAF		49.86	13.17
CGI		3.85	1.08

Measures	Groups	Relation with WM tests				Relation with PS test		Relation with adaptive functioning

		VWM	Backward Digit Span	Trail B	WUT	Congruent Stroop	Number identification	GAF	CGI
LUT	Schizophrenia	0.59**	0.61*	-0.59*	0.52**	-0.19*	-0.37**	0.26**	0.24*
	Controls	0.59**	0.46*	-0.45*	0.61**	-0.27*	-0.26*
	Total	0.62**	0.56**	-0.45*	0.61**	-0.37**	-0.31**
WUT	Schizophrenia	0.63**	0.44*	-0.42*		-0.26*	-0.29**	0.25**	0.29*
	Controls	0.63**	0.40*	-0.47*		-0.22*	-0.19*
	Total	0.72*	0.45**	-0.32*		-0.30*	0.36*

Test Score	Factor 1	Factor 2
Schizophrenia
LUT	0.81
WUT	0.80
VWM	0.81
Backward Digit Span	0.70
Color naming (Stroop)	-0.44
Number Identification	-0.55
Controls
LUT	0.80
WUT	0.88
VWM	0.87
Backward Digit Span	0.59
Color naming (Stroop)		0.74
Number Identification		0.78

	Schizophrenia group	Control group

	Average (SD)	Average (SD)	df	F	p <	d Cohen
LUT	114.50 (26.43)	130.96 (18.17)	1.25	52.10	0.001	0.71
WUT	13.16 (3.82)	16.81 (3.16)	1.25	18.79	0.001	1.31
Color Naming (Stroop)	0.58 (0.16)	0.47 (0.96)	1.25	29.84	0.001	0.15
Number Identification	58.88 (15.84)	52.16 (15.16)	1.25	5.42	0.02	0.43
Digit Span – Backward	0,60 (0,19)	0,67 (0,17)	1.25	9,26	0.003	0.39
TMT – Part A	1.60 (0.20)	1.48 (0.17)	1.25	24.42	0.001	0.64
TMT – Part B	2.09 (0.28)	1.90 (0.20)	1.25	35.24	0.001	0.78
TMT time difference (B-A)	1.88 (0.32)	1.67 (0.23)	1.25	35.55	0.001	0.75
VWM	5.90 (3.96)	8.95 (4.49)	1.25	33.17	0.001	0.72

[1] Address for correspondence: Arthur A. Berberian. Laboratório Interdisciplinar de Neurociências Clínicas. Edifício de Pesquisas II. Rua Pedro de Toledo, 669, 3° andar, fundos, Vila Clementino. 04039-032 – São Paulo, SP, Brazil. Phone: (+55 11) 5576-4845. E-mail: a.berberian@unifesp.br

Brasil

Brasil

Investigação da cognição na esquizofrenia: propriedades psicométricas de instrumentos para avaliação de atualização da memória de trabalho

Objetivo

Métodos

Resultados

Conclusão