Slope 3 |
Cystic fibrosis <12 years old (A) |
Mean ± SD |
44.69 ± 4.91 |
45.79 ± 8.84 |
36.29 ± 4.54 |
37.76 ± 4.47 |
44.38 ± 5.1 |
0.034 (3 ≠ 1, 5)
|
Median Minimum Maximum 95% CI |
38.04 16.38 140.1 34.59-54.8 |
32.01 15.4 246.48 27.6-63.98 |
27.09 13.25 99.47 26.95-45.64 |
28.51 12.15 99.34 28.55-46.96 |
36.84 11.71 135.6 33.9-54.87 |
Controls <12 years old (B) |
Mean ± SD |
24.57 ± 3.51 |
25.32 ± 4.3 |
23.35 ± 4.3 |
21.63 ± 3.16 |
22.85 ± 4.56 |
0.445 |
Median Minimum Maximum 95% CI |
17.63 1.5 91 17.43-31.71 |
19.04 7.17 147.71 16.58-34.05 |
13.5 7.52 97.61 14.62-32.07 |
13.54 6.7 78.08 15.2-28.06 |
14.84 1 163.67 13.6-32.1 |
Cystic fibrosis ≥12 years old (C) |
Mean ± SD |
32.44 ± 3.61 |
28.51 ± 4.15 |
27.49 ± 3.33 |
26.03 ± 3.41 |
33.43 ± 5.24 |
0.006 (4 ≠ 1, 2, 3, 5)
|
Median Minimum Maximum 95% CI |
31.6 5 102.12 25.11-39.78 |
18.13 6.05 123.5 20.10-36.93 |
24.56 6.24 84.87 20.73-34.25 |
20.06 6.51 85.1 19.09-32.96 |
27.52 6.85 170.58 22.80-44.07 |
Controls ≥12 years old (D) |
Mean ± SD |
15.99 ± 1.98 |
13.77 ± 1.55 |
11.89 ± 1 |
11.96 ± 1.48 |
11.93 ± 1.38 |
0.028 (1 ≠ 3, 4, 5)
|
Median Minimum Maximum 95% CI |
13.05 4.79 39.04 11.91-20.07 |
10.84 4.63 36.72 10.57-16.96 |
11.9 4.58 23.6 9.77-13.9 |
9.37 3.5 36.25 8.92-15 |
10.21 1.21 32.95 9.08-14.77 |
|
p-Value |
<0.001
(A ≠ B, C, D; C ≠ A, B, D; B ≠ A, C; D ≠ A, C)
|
0.004
(A ≠ B, C, D; C ≠ A, D; B ≠ A, D; D ≠ A, B, C)
|
<0.001
(A ≠ B, C, D; C ≠ A, D; B ≠ A, D; D ≠ A, B, C)
|
<0.001
(A ≠ B, C, D; C ≠ A, D; B ≠ A, D; D ≠ A, B, C)
|
<0.001
(A ≠ B, C, D; C ≠ A, B, D; B ≠ A, C, D; D ≠ A, B, C)
|
|
Slope 3/tidal volume |
Cystic fibrosis <12 years old (A) |
Mean ± SD |
0.21 ± 0.04 |
0.25 ± 0.11 |
0.15 ± 0.02 |
0.14 ± 0.02 |
0.2 ± 0.03 |
<0.001
(1 and 5 ≠ 2, 3, 4; 2 ≠ 1, 3, 5; 3 ≠ 1, 2, 5; 4 ≠ 1, 5)
|
Median Minimum Maximum 95% CI |
0.14 0.04 1.4 0.11-0.32 |
0.09 0.02 3.04 0.02-0.48 |
0.07 0.02 0.54 0.09-0.2 |
0.08 0.02 0.52 0.09-0.2 |
0.18 0.02 0.98 0.12-0.27 |
Controls <12 years old (B) |
Mean ± SD |
0.09 ± 0.02 |
0.1 ± 0.04 |
0.09 ± 0.02 |
0.07 ± 0.02 |
0.1 ± 0.04 |
0.005
(1 and 5 ≠ 3, 4; 2 ≠ 4; 3 ≠ 1, 5; 4 ≠ 1, 2, 5)
|
Median Minimum Maximum 95% CI |
0.05 0 0.67 0.05-0.13 |
0.03 0.01 1.74 0.01-0.2 |
0.02 0.01 0.76 0.03-0.14 |
0.02 0.01 0.85 0.02-0.12 |
0.03 0 1.41 0.02-0.18 |
Cystic fibrosis ≥12 years old (C) |
Mean ± SD |
0.12 ± 0.02 |
0.08 ± 0.02 |
0.07 ± 0.01 |
0.07 ± 0.01 |
0.16 ± 0.05 |
<0.001
(1 and 5 ≠ 2, 3, 4; 2 and 3 ≠ 1, 4, 5; 4 ≠ 1, 2, 3, 5)
|
Median Minimum Maximum 95% CI |
0.07 0.01 0.64 0.07-0.16 |
0.03 0.01 0.57 0.04-0.12 |
0.03 0 0.51 0.04-0.11 |
0.03 0 0.49 0.03-0.1 |
0.07 0.01 2.05 0.04-0.27 |
Controls ≥12 years old (D) |
Mean ± SD |
0.04 ± 0 |
0.02 ± 0 |
0.01 ± 0 |
0.01 ± 0 |
0.02 ± 0 |
0.001
(1 ≠ 2, 3, 4, 5; 2 and 5 ≠ 1, 4; 3 ≠ 1; 4 ≠ 1, 2, 5)
|
Median Minimum Maximum 95% CI |
0.02 0.01 0.15 0.02-0.05 |
0.01 0 0.07 0.01-0.03 |
0.01 0 0.04 0.01-0.02 |
0.01 0 0.08 0.01-0.02 |
0.01 0 0.09 0.01-0.03 |
|
p-Value |
<0.001
(A ≠ B, C, D; C ≠ A, D; B ≠ A, D; D ≠ A, B, C)
|
<0.001
(A ≠ B, C, D; C ≠ A, D; B ≠ A, D; D ≠ A, B, C)
|
<0.001
(A ≠ B, C, D; C ≠ A, D; B ≠ A, D; D ≠ A, B, C)
|
<0.001
(A ≠ B, C, D; C ≠ A, D; B ≠ A, D; D ≠ A, B, C)
|
<0.001
(A ≠ B, C, D; C ≠ A, D; B ≠ A, D; D ≠ A, B, C)
|
|
Slope 2 |
Cystic fibrosis <12 years old (A) |
Mean ± SD |
562.34 ± 28.52 |
537.44 ± 29.71 |
534 ± 32.3 |
529.34 ± 33.79 |
551.43 ± 28.59 |
0.017
(1 and 5 ≠ 3, 4)
|
Median Minimum Maximum 95% CI |
548.63 332.84 940.17 503.7-620.97 |
554.58 340.24 1003.17 476.35-598.52 |
549.36 279.94 1070.96 467.59-600.41 |
566.16 277.46 919.83 459.87-598.8 |
553.21 304.51 871.09 492.66-610.2 |
Controls <12 years old (B) |
Mean ± SD |
517.42 ± 30.66 |
470.71 ± 20.77 |
460.03 ± 24.62 |
462.76 ± 22.44 |
490.97 ± 28.59 |
0.497 |
Median Minimum Maximum 95% CI |
476.5 273 1215.58 455.22-579.62 |
450.06 272.59 791.22 428.58-512.84 |
421.89 287.67 816.03 410.09-509.97 |
427 293.25 779.63 417.23-508.29 |
462.52 277.14 1184.37 432.98-548.96 |
Cystic fibrosis ≥12 years old (C) |
Mean ± SD |
432.98 ± 28.01 |
386.08 ± 22.62 |
390.08 ± 24.47 |
380.49 ± 29.75 |
434.15 ± 35.87 |
0.003
(4 ≠ 1, 3, 5)
|
Median Minimum Maximum 95% CI |
400.21 140 833.67 376.17-489.79 |
381.25 147.49 708.09 340.18-431.97 |
347.12 167.4 924 340.45-439.72 |
366.42 161.66 1173.23 320.14-440.84 |
430.06 139 1366.24 361.39-506.92 |
Controls ≥12 years old (D) |
Mean ± SD |
371.7 ± 17.82 |
340.37 ± 12.55 |
337.35 ± 12.33 |
335.55 ± 13.72 |
344.05 ± 13.67 |
0.244 |
Median Minimum Maximum 95% CI |
351 225.88 602.15 335.07-408.33 |
334.85 228.65 464.55 314.56-366.18 |
338.1 207.82 471.01 311.99-362.71 |
340.32 207.76 519.02 307.34-363.76 |
341.68 240.28 501.23 315.94-372.17 |
|
p-Value |
<0.001
(A ≠ C, D; C ≠ A, B; B ≠ C, D; D ≠ A, B)
|
<0.001
(A ≠ C, D; C ≠ A, B; B ≠ C, D; D ≠ A, B)
|
<0.001
(A ≠ C, D; C ≠ A, B; B ≠ C, D; D ≠ A, B)
|
<0.001
(A ≠ C, D; C ≠ A, B; B ≠ C, D; D ≠ A, B)
|
<0.001
(A ≠ C, D; C ≠ A, B, D; B ≠ C, D; D ≠ A, B, C)
|
|