Factors associated with developmental delay in late preterm infants: the BRISA cohort

Abstract

Objective  To investigate the association of sociodemographic characteristics, gestational factors, and birth outcomes with developmental delay from the second year of life in late preterm (LPT) infants.

Method  This study included 327 LPT infants from a cohort started in 2010. Developmental performance was assessed using the Bayley-III screening test. The covariates were obtained with questionnaires and from the maternity records. Hierarchical multiple logistic regression was used for analysis.

Results  Smoking during pregnancy was associated with fine motor and cognitive delays (OR = 2.27, 95 %CI 1.05-4.93 and OR = 2.22, 95 %CI 1.05-4.68, respectively). Living without a partner (OR = 2.98, 95 %CI 1.36-6.52) and intrauterine growth restriction of the child (OR = 2.63, 95 %CI 1.32-5.24) were associated with fine motor delay and neonatal intensive care unit admission with cognitive delay (OR = 2.11, 95 %CI 1.01-4.44).

Conclusions  These factors must be considered when implementing strategies for the diagnosis of possible developmental delays and when designing interventions for LPT children.

Keywords
Cohort studies; Risk factors; Premature birth; Cognition; Motor skills