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Effect of levofloxacin on intestinal microbiota of patients with community-acquired pneumonia

A. M. P. Silva About the author

THESIS

Effect of levofloxacin on intestinal microbiota of patients with community-acquired pneumonia

Correspondence to Correspondence to: Ângela Mara Pinto da Silva Faculdade de Odontologia de Lins, Universidade Metodista de Piracicaba, UNIMEP Rua Florêncio Pupo Netto, 300 Lins, SP, Brasil, CEP 16400-680 Phone: +55 14 3533 6000 Email: amsilva@unimep.br / silvaamp@uol.com.br

Thesis: A. M. P. Silva submitted this dissertation for her Masters in Tropical Diseases at Botucatu Medical School, São Paulo State University, UNESP, Botucatu, São Paulo State, Brazil, 2008.

Advisor: Professor Paulo Câmara Marques Pereira

ABSTRACT

The gastrointestinal tract is a complex ecosystem that associates resident microbiota and cells of different phenotypes lining the epithelial wall that express intricate metabolic activities. The microbiota can be changed during the infectious process and/or medication use. This alteration can interfere in food digestion, nutrient absorption, rapid immune response against pathogens and hinder stimulation and maturation of the immune system. The ecosystem imbalance alters microorganism populations of intestinal microbiota, especially of Bacteroides, Bifidobacterium and Lactobacillus, that can provoke much damage to the host. Thus, this study aims to verify the influence of monotherapy with levofloxacin against community-acquired pneumonia, by oral administration, on normal intestinal microbiota of the patient. Through microbiological analysis of stool samples from 15 patients, it could be verified that community-acquired pneumonia affected intestinal microbiota leading to reductions in the Lactobacillus and Bacteroides populations. The treatment with levofloxacin altered these populations. However, 30 days after the end of the treatment, intestinal microbiota returned to its normal level. Since the incidence of community-acquired pneumonia is high and the most used antimicrobial drug for its treatment is levofloxacin, it is important to understand alterations imposed by this agent on intestinal microbiota and the right decisions to minimize its harmful effects.

Key Words: intestinal microbiota, levofloxacin, pneumonia, Bifidobacterium, Lactobacillus, Bacteroides

  • Correspondence to:

    Ângela Mara Pinto da Silva
    Faculdade de Odontologia de Lins, Universidade Metodista de Piracicaba, UNIMEP
    Rua Florêncio Pupo Netto, 300
    Lins, SP, Brasil, CEP 16400-680
    Phone: +55 14 3533 6000
    Email:
  • Publication Dates

    • Publication in this collection
      09 Sept 2008
    • Date of issue
      2008
    Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) Av. Universitária, 3780, Fazenda Lageado, Botucatu, SP, CEP 18610-034, Brasil, Tel.: +55 14 3880-7693 - Botucatu - SP - Brazil
    E-mail: editorial.jvatitd@unesp.br